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We re\u2010analyzed previously published single\u2010cell data and discovered a strong correlation between microglia and RNV diseases, particularly ROP. Subsequently, we found that reactive oxygen species reduced autophagy\u2010dependent protein degradation of absent in melanoma 2 (AIM2) in hypoxic BV2 cells, leading to increased AIM2 protein accumulation. Furthermore, we engineered AIM2 knockout mice and observed that the RNV was significantly reduced compared to wild\u2010type mice. In vitro vascular function assays also demonstrated diminished angiogenic capabilities following AIM2 knockdown in hypoxic BV2 cells. Mechanistically, AIM2 enhanced the M1\u2010type polarization of microglia via the ASC\/CASP1\/IL\u20101\u03b2 pathway, resulting in RNV. Notably, the administration of recombinant protein IL\u20101\u03b2 exacerbated angiogenesis, while its inhibition ameliorated the condition. Taken together, our study provides a novel therapeutic target for ROP and offers insight into the interaction between pyroptosis and autophagy.<\/jats:p>","DOI":"10.1002\/mco2.668","type":"journal-article","created":{"date-parts":[[2024,7,30]],"date-time":"2024-07-30T03:55:48Z","timestamp":1722311748000},"source":"Crossref","is-referenced-by-count":12,"title":["Autophagy\u2010mediated activation of the AIM2 inflammasome enhances M1 polarization of microglia and exacerbates retinal neovascularization"],"prefix":"10.1002","volume":"5","author":[{"given":"Xianyang","family":"Liu","sequence":"first","affiliation":[{"name":"The First Affiliated Hospital of Chongqing Medical University  Chongqing China"},{"name":"Chongqing Key Laboratory of Ophthalmology  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Zhou","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Chongqing Medical University  Chongqing 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