{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T16:27:56Z","timestamp":1788193676276,"version":"build-2803163510"},"reference-count":475,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2024,8,4]],"date-time":"2024-08-04T00:00:00Z","timestamp":1722729600000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2024,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Posttranslational modifications play a crucial role in governing cellular functions and protein behavior. Researchers have implicated dysregulated posttranslational modifications in protein misfolding, which results in cytotoxicity, particularly in neurodegenerative diseases such as Alzheimer disease, Parkinson disease, and Huntington disease. These aberrant posttranslational modifications cause proteins to gather in certain parts of the brain that are linked to the development of the diseases. This leads to neuronal dysfunction and the start of neurodegenerative disease symptoms. Cognitive decline and neurological impairments commonly manifest in neurodegenerative disease patients, underscoring the urgency of comprehending the posttranslational modifications\u2019 impact on protein function for targeted therapeutic interventions. This review elucidates the critical link between neurodegenerative diseases and specific posttranslational modifications, focusing on Tau, APP, \u03b1\u2010synuclein, Huntingtin protein, Parkin, DJ\u20101, and Drp1. By delineating the prominent aberrant posttranslational modifications within Alzheimer disease, Parkinson disease, and Huntington disease, the review underscores the significance of understanding the interplay among these modifications. Emphasizing 10 key abnormal posttranslational modifications, this study aims to provide a comprehensive framework for investigating neurodegenerative diseases holistically. The insights presented herein shed light on potential therapeutic avenues aimed at modulating posttranslational modifications to mitigate protein aggregation and retard neurodegenerative disease progression.<\/jats:p>","DOI":"10.1002\/mco2.674","type":"journal-article","created":{"date-parts":[[2024,8,5]],"date-time":"2024-08-05T04:48:33Z","timestamp":1722833313000},"source":"Crossref","is-referenced-by-count":23,"title":["Protein modification in neurodegenerative diseases"],"prefix":"10.1002","volume":"5","author":[{"given":"Shahin","family":"Ramazi","sequence":"first","affiliation":[{"name":"Department of Biophysics Faculty of Biological Sciences Tarbiat Modares University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maedeh","family":"Dadzadi","sequence":"additional","affiliation":[{"name":"Department of Biotechnology Faculty of Advanced Science and Technology Tehran Medical Sciences Islamic Azad University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Darvazi","sequence":"additional","affiliation":[{"name":"Department of Biophysics Faculty of Biological Sciences Tarbiat Modares University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasrin","family":"Seddigh","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Advanced Science and Technology Tehran Medical Sciences Islamic Azad University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abdollah","family":"Allahverdi","sequence":"additional","affiliation":[{"name":"Department of Biophysics Faculty of Biological Sciences Tarbiat Modares University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,8,4]]},"reference":[{"key":"e_1_2_20_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-023-05581-w"},{"key":"e_1_2_20_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gpb.2023.03.007"},{"key":"e_1_2_20_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/database\/baab012"},{"key":"e_1_2_20_5_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom14010118"},{"key":"e_1_2_20_6_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biochem.7b00861"},{"key":"e_1_2_20_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12038-020-00099-2"},{"key":"e_1_2_20_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/database\/baad094"},{"key":"e_1_2_20_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-023-01189-y"},{"key":"e_1_2_20_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2021.101336"},{"key":"e_1_2_20_11_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.106955"},{"key":"e_1_2_20_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt0303-255"},{"key":"e_1_2_20_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkl207"},{"key":"e_1_2_20_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23115938"},{"key":"e_1_2_20_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2276"},{"issue":"1","key":"e_1_2_20_16_1","first-page":"27","article-title":"Post\u2010translational modifications in neurodegeneration","volume":"3","author":"Didonna A","year":"2016","journal-title":"Ageing Res Rev"},{"key":"e_1_2_20_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-013-8266-6"},{"issue":"1","key":"e_1_2_20_18_1","first-page":"591","article-title":"SUMO: a (oxidative) stressed protein","volume":"16","author":"Melchior F","year":"2000","journal-title":"Neuromolecular Med"},{"key":"e_1_2_20_19_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.73.011303.074118"},{"issue":"5","key":"e_1_2_20_20_1","article-title":"Computational prediction of proteins sumoylation: a review on the methods and databases","volume":"3","author":"Ramazi S","year":"2016","journal-title":"J Nanomed Res"},{"key":"e_1_2_20_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi0345283"},{"key":"e_1_2_20_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11030-009-9149-5"},{"key":"e_1_2_20_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2005.03.012"},{"key":"e_1_2_20_24_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200206106"},{"key":"e_1_2_20_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.401"},{"key":"e_1_2_20_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2018.02.004"},{"key":"e_1_2_20_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2007.03.017"},{"key":"e_1_2_20_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.1244"},{"key":"e_1_2_20_29_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M510127200"},{"key":"e_1_2_20_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.12.023"},{"key":"e_1_2_20_31_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104714200"},{"key":"e_1_2_20_32_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13010008"},{"key":"e_1_2_20_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10112825"},{"key":"e_1_2_20_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2004.09.021"},{"key":"e_1_2_20_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/jms.2959"},{"key":"e_1_2_20_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac1055"},{"key":"e_1_2_20_37_1","doi-asserted-by":"publisher","DOI":"10.14336\/AD.2014.1205"},{"key":"e_1_2_20_38_1","doi-asserted-by":"publisher","DOI":"10.1159\/000502142"},{"key":"e_1_2_20_39_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202002702R"},{"key":"e_1_2_20_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04957-4"},{"key":"e_1_2_20_41_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-6-12"},{"key":"e_1_2_20_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2009.07.021"},{"key":"e_1_2_20_43_1","volume-title":"PML and its Degradation by Arsenic Trioxide in Interferon\u2010Mediated Neuro\u2010Inflammation","author":"Chevallot\u2010Beroux M","year":"2023"},{"key":"e_1_2_20_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2013.04.050"},{"key":"e_1_2_20_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.15103"},{"key":"e_1_2_20_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbamcr.2014.07.018"},{"key":"e_1_2_20_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep10730"},{"key":"e_1_2_20_48_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00008.2014"},{"key":"e_1_2_20_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2019.00486"},{"key":"e_1_2_20_50_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M501677200"},{"key":"e_1_2_20_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12017-013-8257-7"},{"key":"e_1_2_20_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2021.643115"},{"key":"e_1_2_20_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232315383"},{"key":"e_1_2_20_54_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms15034671"},{"key":"e_1_2_20_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/adpr.202200044"},{"key":"e_1_2_20_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13600"},{"key":"e_1_2_20_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2009.01.004"},{"key":"e_1_2_20_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232112841"},{"key":"e_1_2_20_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2015.1"},{"key":"e_1_2_20_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.786353"},{"key":"e_1_2_20_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-022-02734-5"},{"key":"e_1_2_20_62_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1417548111"},{"key":"e_1_2_20_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2008.06.012"},{"key":"e_1_2_20_64_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.85.19.7341"},{"key":"e_1_2_20_65_1","doi-asserted-by":"publisher","DOI":"10.1186\/1756-6606-4-3"},{"key":"e_1_2_20_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2020.154454"},{"key":"e_1_2_20_67_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2020.00137"},{"key":"e_1_2_20_68_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2020.02.001"},{"key":"e_1_2_20_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-6-27"},{"key":"e_1_2_20_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2011.116"},{"key":"e_1_2_20_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01249-0"},{"key":"e_1_2_20_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2024.108828"},{"key":"e_1_2_20_73_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom11111635"},{"key":"e_1_2_20_74_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a006288"},{"key":"e_1_2_20_75_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2020.600084"},{"key":"e_1_2_20_76_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2017.00294"},{"key":"e_1_2_20_77_1","doi-asserted-by":"publisher","DOI":"10.1358\/dnp.2009.22.5.1378636"},{"key":"e_1_2_20_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep07190"},{"key":"e_1_2_20_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2012.08.005"},{"key":"e_1_2_20_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2008.07.109"},{"key":"e_1_2_20_81_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1800498115"},{"key":"e_1_2_20_82_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1288506"},{"key":"e_1_2_20_83_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.15870"},{"key":"e_1_2_20_84_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0235361100"},{"key":"e_1_2_20_85_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20061451"},{"key":"e_1_2_20_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2020.09.003"},{"key":"e_1_2_20_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-022-03063-3"},{"key":"e_1_2_20_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-021-00280-3"},{"key":"e_1_2_20_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cger.2019.08.002"},{"key":"e_1_2_20_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2017.12.007"},{"key":"e_1_2_20_91_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2021.736978"},{"key":"e_1_2_20_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2010.06.017"},{"key":"e_1_2_20_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2018.10.025"},{"key":"e_1_2_20_94_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a009399"},{"key":"e_1_2_20_95_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-140491"},{"key":"e_1_2_20_96_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0b013e31828727ba"},{"key":"e_1_2_20_97_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.61951"},{"key":"e_1_2_20_98_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-019-0329-1"},{"key":"e_1_2_20_99_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a024091"},{"key":"e_1_2_20_100_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan6160"},{"key":"e_1_2_20_101_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23116216"},{"key":"e_1_2_20_102_1","doi-asserted-by":"publisher","DOI":"10.3389\/fchem.2021.666585"},{"key":"e_1_2_20_103_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1113260108"},{"key":"e_1_2_20_104_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2020.00167"},{"key":"e_1_2_20_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2019.03.001"},{"key":"e_1_2_20_106_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-020-02157-3"},{"key":"e_1_2_20_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-019-0598-9"},{"key":"e_1_2_20_108_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz104"},{"key":"e_1_2_20_109_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M600933200"},{"key":"e_1_2_20_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63633-4"},{"key":"e_1_2_20_111_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi0485528"},{"key":"e_1_2_20_112_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1704351114"},{"key":"e_1_2_20_113_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi501512m"},{"key":"e_1_2_20_114_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddm363"},{"key":"e_1_2_20_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2011.04.015"},{"key":"e_1_2_20_116_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.22798"},{"issue":"2","key":"e_1_2_20_117_1","first-page":"67","article-title":"The role of parkin in Parkinson's disease","volume":"16","author":"Miklya I","year":"2014","journal-title":"Neuropsychopharmacol Hung"},{"key":"e_1_2_20_118_1","first-page":"1","article-title":"Post\u2010translational modification of Parkin and its research progress in cancer","volume":"39","author":"Ding D","year":"2019","journal-title":"Cancer Commun (Lond)"},{"key":"e_1_2_20_119_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-020-00229-8"},{"key":"e_1_2_20_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm1067"},{"key":"e_1_2_20_121_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2015.00248"},{"key":"e_1_2_20_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2021.114650"},{"key":"e_1_2_20_123_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40880-018-0314-z","article-title":"Parkinson's disease\u2010associated protein Parkin: an unusual player in cancer","volume":"38","author":"Liu J","year":"2018","journal-title":"Cancer Commun (Lond)"},{"key":"e_1_2_20_124_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13062-017-0176-3"},{"key":"e_1_2_20_125_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.e03-02-0078"},{"key":"e_1_2_20_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2005.07.023"},{"key":"e_1_2_20_127_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M407724200"},{"key":"e_1_2_20_128_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1004391"},{"key":"e_1_2_20_129_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.21041"},{"key":"e_1_2_20_130_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13599"},{"key":"e_1_2_20_131_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-10-6583-5_2"},{"key":"e_1_2_20_132_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00994"},{"key":"e_1_2_20_133_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx294"},{"key":"e_1_2_20_134_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awh054"},{"key":"e_1_2_20_135_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M509079200"},{"key":"e_1_2_20_136_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-10-6583-5_3"},{"key":"e_1_2_20_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2014.11.012"},{"key":"e_1_2_20_138_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1997.6132"},{"key":"e_1_2_20_139_1","doi-asserted-by":"publisher","DOI":"10.1155\/2013\/683920"},{"issue":"5","key":"e_1_2_20_140_1","first-page":"1115","article-title":"DJ1 promotes cell proliferation and tumor metastasis in esophageal squamous cell carcinoma via the Wnt\/\u03b2catenin signaling pathway Corrigendum in\/10.3892\/ijo. 2022.5320","volume":"56","author":"Jin F","year":"2020","journal-title":"Int J Oncol"},{"key":"e_1_2_20_141_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-10-6583-5_4"},{"key":"e_1_2_20_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.101884"},{"key":"e_1_2_20_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2021.102114"},{"key":"e_1_2_20_144_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2018.00612"},{"key":"e_1_2_20_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2018.11.021"},{"key":"e_1_2_20_146_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-019-1679-x"},{"key":"e_1_2_20_147_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2017.00308"},{"key":"e_1_2_20_148_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4401704"},{"key":"e_1_2_20_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2008.03.003"},{"key":"e_1_2_20_150_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00068"},{"key":"e_1_2_20_151_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2003.02265.x"},{"key":"e_1_2_20_152_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M304272200"},{"key":"e_1_2_20_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2020.107594"},{"key":"e_1_2_20_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep43811"},{"key":"e_1_2_20_155_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8090961"},{"key":"e_1_2_20_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresrev.2010.11.004"},{"key":"e_1_2_20_157_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.893018"},{"key":"e_1_2_20_158_1","doi-asserted-by":"publisher","DOI":"10.1161\/RES.0000000000000104"},{"key":"e_1_2_20_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcb.2012.10.006"},{"key":"e_1_2_20_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.103484"},{"key":"e_1_2_20_161_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.09-136630"},{"key":"e_1_2_20_162_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-020-00518-y"},{"key":"e_1_2_20_163_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.71"},{"key":"e_1_2_20_164_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm1697"},{"key":"e_1_2_20_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2417"},{"key":"e_1_2_20_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2019.07.009"},{"key":"e_1_2_20_167_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds072"},{"key":"e_1_2_20_168_1","first-page":"65","article-title":"The biological function of the Huntingtin protein and its relevance to Huntington's disease pathology","volume":"5","author":"Schulte J","year":"2011","journal-title":"Curr Trends Neurol"},{"key":"e_1_2_20_169_1","first-page":"387","article-title":"13 Mouse models of Huntington's disease","volume":"45","author":"Bates GP","year":"2002","journal-title":"Med Mol Genet."},{"key":"e_1_2_20_170_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2107187119"},{"key":"e_1_2_20_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ibneur.2022.03.002"},{"key":"e_1_2_20_172_1","doi-asserted-by":"publisher","DOI":"10.1097\/00005072-199805000-00001"},{"key":"e_1_2_20_173_1","doi-asserted-by":"publisher","DOI":"10.1038\/321168a0"},{"key":"e_1_2_20_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.02.003"},{"key":"e_1_2_20_175_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858410390378"},{"key":"e_1_2_20_176_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.154108"},{"key":"e_1_2_20_177_1","first-page":"1","article-title":"A simple role for BDNF in learning and memory?","volume":"3","author":"Cunha C","year":"2010","journal-title":"Front Mol Neurosci"},{"key":"e_1_2_20_178_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2022.927479"},{"key":"e_1_2_20_179_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25502"},{"key":"e_1_2_20_180_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.11184"},{"key":"e_1_2_20_181_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b10893"},{"key":"e_1_2_20_182_1","doi-asserted-by":"publisher","DOI":"10.1093\/braincomms\/fcaa231"},{"key":"e_1_2_20_183_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092194"},{"key":"e_1_2_20_184_1","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13413"},{"key":"e_1_2_20_185_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-78790-5"},{"key":"e_1_2_20_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(93)90585-E"},{"key":"e_1_2_20_187_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.252577"},{"key":"e_1_2_20_188_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng0893-387"},{"key":"e_1_2_20_189_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-020-0389-4"},{"key":"e_1_2_20_190_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbic.202000508"},{"key":"e_1_2_20_191_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-25903-w"},{"key":"e_1_2_20_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2013.06.034"},{"key":"e_1_2_20_193_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11213395"},{"key":"e_1_2_20_194_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1172871"},{"issue":"6","key":"e_1_2_20_195_1","first-page":"2223","article-title":"Bioinformatics analysis of Ras homologue enriched in the striatum, a potential target for Huntington's disease therapy","volume":"44","author":"Carbo M","year":"2019","journal-title":"Int J Mol Med"},{"key":"e_1_2_20_196_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.9b00509"},{"key":"e_1_2_20_197_1","doi-asserted-by":"publisher","DOI":"10.1093\/bib\/bbac015"},{"key":"e_1_2_20_198_1","doi-asserted-by":"publisher","DOI":"10.1002\/9781119053354"},{"key":"e_1_2_20_199_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2018.00373"},{"key":"e_1_2_20_200_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlad066"},{"key":"e_1_2_20_201_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170176"},{"key":"e_1_2_20_202_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0490-10.2010"},{"key":"e_1_2_20_203_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-022-01150-0"},{"key":"e_1_2_20_204_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.aaz2387"},{"key":"e_1_2_20_205_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.57078"},{"key":"e_1_2_20_206_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-023-02113-z"},{"key":"e_1_2_20_207_1","doi-asserted-by":"publisher","DOI":"10.2174\/092986708785909111"},{"key":"e_1_2_20_208_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2021.607303"},{"key":"e_1_2_20_209_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.15909"},{"key":"e_1_2_20_210_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-021-00460-5"},{"key":"e_1_2_20_211_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2015.225"},{"key":"e_1_2_20_212_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2010.12.023"},{"key":"e_1_2_20_213_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.332125"},{"key":"e_1_2_20_214_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2019.00980"},{"key":"e_1_2_20_215_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.12502"},{"key":"e_1_2_20_216_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2023.103487"},{"key":"e_1_2_20_217_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-019-0333-5"},{"key":"e_1_2_20_218_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.110957"},{"key":"e_1_2_20_219_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-018-0557-6"},{"key":"e_1_2_20_220_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.103836"},{"key":"e_1_2_20_221_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.2007.00053.x"},{"key":"e_1_2_20_222_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.707268"},{"key":"e_1_2_20_223_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242417225"},{"key":"e_1_2_20_224_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-020-0938-9"},{"key":"e_1_2_20_225_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2021.03.003"},{"key":"e_1_2_20_226_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.10.029"},{"key":"e_1_2_20_227_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.3c07285"},{"key":"e_1_2_20_228_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34129-4"},{"key":"e_1_2_20_229_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00338"},{"key":"e_1_2_20_230_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-021-00270-1"},{"key":"e_1_2_20_231_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx381"},{"key":"e_1_2_20_232_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-023-02853-3"},{"key":"e_1_2_20_233_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1145318"},{"key":"e_1_2_20_234_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-83910-w"},{"key":"e_1_2_20_235_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-020-00841-6"},{"key":"e_1_2_20_236_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00355"},{"key":"e_1_2_20_237_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M112.433326"},{"key":"e_1_2_20_238_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2021.102072"},{"key":"e_1_2_20_239_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2011.03.005"},{"key":"e_1_2_20_240_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2014.216"},{"key":"e_1_2_20_241_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9081807"},{"key":"e_1_2_20_242_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M113.538710"},{"key":"e_1_2_20_243_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21010209"},{"key":"e_1_2_20_244_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.008310"},{"key":"e_1_2_20_245_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200301115"},{"key":"e_1_2_20_246_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.100362"},{"key":"e_1_2_20_247_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.02393-05"},{"issue":"12","key":"e_1_2_20_248_1","first-page":"2498","article-title":"Inhibition of death\u2010associated protein kinase 1 attenuates the phosphorylation and amyloidogenic processing of amyloid precursor protein","volume":"25","author":"Kim BM","year":"2016","journal-title":"Hum Mol Genet"},{"key":"e_1_2_20_249_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1546-0"},{"key":"e_1_2_20_250_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.29043"},{"key":"e_1_2_20_251_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.012284"},{"key":"e_1_2_20_252_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1922741117"},{"key":"e_1_2_20_253_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S235562"},{"key":"e_1_2_20_254_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.382231"},{"key":"e_1_2_20_255_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01486-5"},{"key":"e_1_2_20_256_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21145030"},{"key":"e_1_2_20_257_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-05672-9"},{"key":"e_1_2_20_258_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2019.577089"},{"key":"e_1_2_20_259_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2023.11.020"},{"key":"e_1_2_20_260_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-160779"},{"key":"e_1_2_20_261_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.C800206200"},{"key":"e_1_2_20_262_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2109617119"},{"key":"e_1_2_20_263_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0482-05.2005"},{"key":"e_1_2_20_264_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI85456"},{"key":"e_1_2_20_265_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddt674"},{"key":"e_1_2_20_266_1","first-page":"3","volume-title":"Parkinson's Disease: Etiology, Neuropathology, and Pathogenesis","author":"Kouli A","year":"2018"},{"key":"e_1_2_20_267_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awad388"},{"key":"e_1_2_20_268_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.15257"},{"key":"e_1_2_20_269_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2018.00809"},{"key":"e_1_2_20_270_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.01.030"},{"key":"e_1_2_20_271_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-022-00384-x"},{"key":"e_1_2_20_272_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2018.00123"},{"key":"e_1_2_20_273_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20160498"},{"key":"e_1_2_20_274_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40035-015-0049-6"},{"key":"e_1_2_20_275_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-023-01704-9"},{"key":"e_1_2_20_276_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2015.02.032"},{"key":"e_1_2_20_277_1","doi-asserted-by":"publisher","DOI":"10.1038\/cddis.2017.524"},{"key":"e_1_2_20_278_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10040885"},{"key":"e_1_2_20_279_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201948686"},{"key":"e_1_2_20_280_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA118.004621"},{"key":"e_1_2_20_281_1","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-230569"},{"key":"e_1_2_20_282_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awv107"},{"key":"e_1_2_20_283_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200909067"},{"key":"e_1_2_20_284_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0088284"},{"key":"e_1_2_20_285_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2020104671"},{"key":"e_1_2_20_286_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1705372114"},{"key":"e_1_2_20_287_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1814246116"},{"key":"e_1_2_20_288_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2022.01.020"},{"key":"e_1_2_20_289_1","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-220557"},{"key":"e_1_2_20_290_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-017-1786-7"},{"key":"e_1_2_20_291_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2022.07.014"},{"key":"e_1_2_20_292_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awx255"},{"key":"e_1_2_20_293_1","doi-asserted-by":"publisher","DOI":"10.1016\/B0-12-475570-4\/00003-2"},{"key":"e_1_2_20_294_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbapap.2016.06.007"},{"key":"e_1_2_20_295_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2020.08.005"},{"key":"e_1_2_20_296_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-021-00556-4"},{"key":"e_1_2_20_297_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-019-0354-0"},{"key":"e_1_2_20_298_1","doi-asserted-by":"publisher","DOI":"10.5772\/54487"},{"key":"e_1_2_20_299_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci10040232"},{"key":"e_1_2_20_300_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep08512"},{"key":"e_1_2_20_301_1","doi-asserted-by":"publisher","DOI":"10.1039\/c2sm25662b"},{"key":"e_1_2_20_302_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2019.01.056"},{"key":"e_1_2_20_303_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170702"},{"key":"e_1_2_20_304_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0101-9"},{"key":"e_1_2_20_305_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkq900"},{"key":"e_1_2_20_306_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpj.2010.07.017"},{"key":"e_1_2_20_307_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.86"},{"key":"e_1_2_20_308_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/6690523"},{"key":"e_1_2_20_309_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1786-08.2008"},{"key":"e_1_2_20_310_1","first-page":"50","article-title":"NF\u2010\u03baB transcription factor role in consolidation and reconsolidation of persistent memories","volume":"8","author":"Fuente V","year":"2015","journal-title":"Front Mol Neurosci"},{"key":"e_1_2_20_311_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.86605"},{"key":"e_1_2_20_312_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00537"},{"key":"e_1_2_20_313_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2021.661117"},{"key":"e_1_2_20_314_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tibs.2016.07.005"},{"key":"e_1_2_20_315_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx114"},{"key":"e_1_2_20_316_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddl243"},{"key":"e_1_2_20_317_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-009-9090-5"},{"key":"e_1_2_20_318_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-013-0211-8"},{"key":"e_1_2_20_319_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2012.05.024"},{"key":"e_1_2_20_320_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20184535"},{"key":"e_1_2_20_321_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2011.22"},{"key":"e_1_2_20_322_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4286"},{"key":"e_1_2_20_323_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1206-6"},{"key":"e_1_2_20_324_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.250575"},{"key":"e_1_2_20_325_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.675488"},{"key":"e_1_2_20_326_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.01.013"},{"key":"e_1_2_20_327_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2012.01.011"},{"key":"e_1_2_20_328_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuro.2011.05.018"},{"key":"e_1_2_20_329_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13172"},{"key":"e_1_2_20_330_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00702-018-1902-4"},{"key":"e_1_2_20_331_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241310848"},{"key":"e_1_2_20_332_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-013-0206-5"},{"key":"e_1_2_20_333_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-9525(03)00074-X"},{"key":"e_1_2_20_334_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes14040873"},{"key":"e_1_2_20_335_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0166-2236(00)01609-X"},{"key":"e_1_2_20_336_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1072613"},{"key":"e_1_2_20_337_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.100110097"},{"key":"e_1_2_20_338_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1056784"},{"key":"e_1_2_20_339_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M410210200"},{"key":"e_1_2_20_340_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2005.03077.x"},{"key":"e_1_2_20_341_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-020-00667-x"},{"key":"e_1_2_20_342_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2020.101078"},{"key":"e_1_2_20_343_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-05460-0"},{"key":"e_1_2_20_344_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-020-01262-x"},{"key":"e_1_2_20_345_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-0107-0"},{"key":"e_1_2_20_346_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.261"},{"key":"e_1_2_20_347_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-020-00706-7"},{"key":"e_1_2_20_348_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2016.00303"},{"key":"e_1_2_20_349_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0092098"},{"key":"e_1_2_20_350_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23126808"},{"key":"e_1_2_20_351_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1109356108"},{"key":"e_1_2_20_352_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2014.12.007"},{"key":"e_1_2_20_353_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0770-z"},{"key":"e_1_2_20_354_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41556-019-0356-8"},{"key":"e_1_2_20_355_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22101723"},{"key":"e_1_2_20_356_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12335"},{"key":"e_1_2_20_357_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh083"},{"key":"e_1_2_20_358_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.02.059"},{"key":"e_1_2_20_359_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14246212"},{"key":"e_1_2_20_360_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.775087"},{"key":"e_1_2_20_361_1","doi-asserted-by":"publisher","DOI":"10.1111\/acel.12961"},{"key":"e_1_2_20_362_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm11121309"},{"key":"e_1_2_20_363_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA120.015452"},{"key":"e_1_2_20_364_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1314421111"},{"key":"e_1_2_20_365_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddx394"},{"key":"e_1_2_20_366_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2023.1107323"},{"key":"e_1_2_20_367_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2016.03.016"},{"key":"e_1_2_20_368_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1523597113"},{"key":"e_1_2_20_369_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-46237-1"},{"key":"e_1_2_20_370_1","volume-title":"The Characterization of the PARK10 Gene USP24 in Autophagy and Mitophagy","author":"Thayer JA","year":"2019"},{"key":"e_1_2_20_371_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1598754"},{"key":"e_1_2_20_372_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2019.1656957"},{"key":"e_1_2_20_373_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-016-1663-9"},{"key":"e_1_2_20_374_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13194"},{"key":"e_1_2_20_375_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsyn.2017.00016"},{"key":"e_1_2_20_376_1","first-page":"1513","article-title":"Ataxin\u20103 protein and RNA toxicity in spinocerebellar ataxia type 3: current insights and emerging therapeutic strategies","volume":"49","author":"Evers MM","year":"2014","journal-title":"Mol Neurobiol"},{"key":"e_1_2_20_377_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-023-02446-x"},{"key":"e_1_2_20_378_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41581-019-0129-4"},{"key":"e_1_2_20_379_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-020-03578-9"},{"key":"e_1_2_20_380_1","doi-asserted-by":"publisher","DOI":"10.5498\/wjp.v8.i2.51"},{"key":"e_1_2_20_381_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2020.625348"},{"key":"e_1_2_20_382_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11030581"},{"key":"e_1_2_20_383_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom10111569"},{"key":"e_1_2_20_384_1","article-title":"Excess APP O\u2010glycosylation by GalNAc\u2010T6 decreases A\u03b2 production","author":"Akasaka\u2010Manya K","year":"2016","journal-title":"J Biochem"},{"key":"e_1_2_20_385_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2017.28"},{"key":"e_1_2_20_386_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2017.04.020"},{"key":"e_1_2_20_387_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.1c00932"},{"key":"e_1_2_20_388_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcpro.2021.100081"},{"key":"e_1_2_20_389_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9AY00381A"},{"key":"e_1_2_20_390_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc5802"},{"key":"e_1_2_20_391_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-020-03643-3"},{"key":"e_1_2_20_392_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-023-01617-5"},{"key":"e_1_2_20_393_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcn\/86.5.1486"},{"key":"e_1_2_20_394_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.13682"},{"key":"e_1_2_20_395_1","doi-asserted-by":"publisher","DOI":"10.3109\/00207459309003322"},{"key":"e_1_2_20_396_1","doi-asserted-by":"publisher","DOI":"10.2119\/molmed.2015.00067"},{"key":"e_1_2_20_397_1","doi-asserted-by":"crossref","unstructured":"Juan et al. paper:Altered cortical palmitoylation induces widespread molecular disturbances in Parkinson's disease International Journal of Molecular Sciences:23(22) https:\/\/www.mdpi.com\/1422-0067\/23\/22\/14018#:~:text=Moreover%2C%20some%20of%20the%20proteins to%20pathological%20mechanisms%20causing%20PD https:\/\/doi.org\/10.3390\/ijms232214018","DOI":"10.3390\/ijms232214018"},{"key":"e_1_2_20_398_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0891-5849(00)00228-8"},{"key":"e_1_2_20_399_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.1985.tb00185.x"},{"key":"e_1_2_20_400_1","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-120044"},{"key":"e_1_2_20_401_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a024240"},{"key":"e_1_2_20_402_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0146480"},{"key":"e_1_2_20_403_1","doi-asserted-by":"publisher","DOI":"10.3233\/JHD-170253"},{"key":"e_1_2_20_404_1","doi-asserted-by":"publisher","DOI":"10.2217\/fnl-2017-0035"},{"key":"e_1_2_20_405_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1342830"},{"key":"e_1_2_20_406_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2023.1166125"},{"key":"e_1_2_20_407_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232214018"},{"key":"e_1_2_20_408_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19123820"},{"key":"e_1_2_20_409_1","doi-asserted-by":"publisher","DOI":"10.1017\/erm.2021.4"},{"key":"e_1_2_20_410_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygeno.2021.03.004"},{"key":"e_1_2_20_411_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11213439"},{"key":"e_1_2_20_412_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24098286"},{"key":"e_1_2_20_413_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-021-00732-z"},{"key":"e_1_2_20_414_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-011-0893-0"},{"key":"e_1_2_20_415_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-021-00468-x"},{"key":"e_1_2_20_416_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20140372"},{"key":"e_1_2_20_417_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-021-00468-x"},{"key":"e_1_2_20_418_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2022.103707"},{"key":"e_1_2_20_419_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.334433.119"},{"key":"e_1_2_20_420_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389203716666150504122435"},{"key":"e_1_2_20_421_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.291518.116"},{"key":"e_1_2_20_422_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2019.04.028"},{"key":"e_1_2_20_423_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.15716"},{"key":"e_1_2_20_424_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12416"},{"key":"e_1_2_20_425_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-012-8258-9"},{"key":"e_1_2_20_426_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.ircmb.2019.12.009"},{"key":"e_1_2_20_427_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aat8407"},{"key":"e_1_2_20_428_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2021.107968"},{"key":"e_1_2_20_429_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2013.05.005"},{"key":"e_1_2_20_430_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2015.10.002"},{"key":"e_1_2_20_431_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2023.1099467"},{"key":"e_1_2_20_432_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaw0843"},{"key":"e_1_2_20_433_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202306469"},{"key":"e_1_2_20_434_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2021.108869"},{"key":"e_1_2_20_435_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.25032"},{"key":"e_1_2_20_436_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.954536"},{"key":"e_1_2_20_437_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.10.068"},{"key":"e_1_2_20_438_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1722452115"},{"key":"e_1_2_20_439_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-61287-6"},{"key":"e_1_2_20_440_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-72630-2"},{"key":"e_1_2_20_441_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0163359"},{"key":"e_1_2_20_442_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2012.4928"},{"key":"e_1_2_20_443_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102242"},{"key":"e_1_2_20_444_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.05.022"},{"key":"e_1_2_20_445_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232012403"},{"key":"e_1_2_20_446_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-27572-2"},{"key":"e_1_2_20_447_1","doi-asserted-by":"publisher","DOI":"10.1098\/rstb.2022.0237"},{"key":"e_1_2_20_448_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fmre.2022.10.009"},{"key":"e_1_2_20_449_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11081279"},{"key":"e_1_2_20_450_1","doi-asserted-by":"publisher","DOI":"10.1039\/C2SM27229F"},{"key":"e_1_2_20_451_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0BM00809E"},{"issue":"11","key":"e_1_2_20_452_1","article-title":"Tau\u2010targeting therapy in Alzheimer's disease: critical advances and future opportunities","volume":"2","author":"Guo Y","year":"2022","journal-title":"Ageing Neur Dis"},{"key":"e_1_2_20_453_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.26006"},{"key":"e_1_2_20_454_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2023.02.075"},{"key":"e_1_2_20_455_1","doi-asserted-by":"publisher","DOI":"10.1002\/iub.2194"},{"key":"e_1_2_20_456_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41531-022-00357-0"},{"key":"e_1_2_20_457_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2019.104636"},{"key":"e_1_2_20_458_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.385288"},{"key":"e_1_2_20_459_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0072301"},{"key":"e_1_2_20_460_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2020.108104"},{"issue":"2","key":"e_1_2_20_461_1","first-page":"366","article-title":"A phase 1 single\u2010ascending\u2010dose trial in healthy volunteers to evaluate the safety, tolerability, pharmacokinetics, and immunogenicity of intravenous PNT001, a novel mid\u2010domain Tau antibody targeting cis\u2010pT231 Tau","volume":"11","author":"Luca W","year":"2024","journal-title":"J Prev Alzheimers Dis"},{"key":"e_1_2_20_462_1","doi-asserted-by":"publisher","DOI":"10.1002\/1873-3468.12907"},{"key":"e_1_2_20_463_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2023.1197853"},{"key":"e_1_2_20_464_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcn.2019.103416"},{"key":"e_1_2_20_465_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2009.01.009"},{"key":"e_1_2_20_466_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1801772115"},{"key":"e_1_2_20_467_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-022-01017-y"},{"key":"e_1_2_20_468_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mcpro.2021.100129"},{"key":"e_1_2_20_469_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12079-019-00538-2"},{"key":"e_1_2_20_470_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.385847"},{"key":"e_1_2_20_471_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.595532"},{"key":"e_1_2_20_472_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-023-03867-x"},{"key":"e_1_2_20_473_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1185671"},{"key":"e_1_2_20_474_1","doi-asserted-by":"publisher","DOI":"10.5530\/ijpi.13.4.089"},{"key":"e_1_2_20_475_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c00844"},{"key":"e_1_2_20_476_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2021.100647"}],"container-title":["MedComm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.674","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,8,16]],"date-time":"2024-08-16T03:36:57Z","timestamp":1723779417000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mco2.674"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,8]]},"references-count":475,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2024,8]]}},"alternative-id":["10.1002\/mco2.674"],"URL":"https:\/\/doi.org\/10.1002\/mco2.674","archive":["Portico"],"relation":{},"ISSN":["2688-2663","2688-2663"],"issn-type":[{"value":"2688-2663","type":"print"},{"value":"2688-2663","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,8]]},"article-number":"e674"}}