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One\u2010carbon metabolism nutrients as therapeutic agents in many diseases might be involved in acute pancreatitis. The roles are acquired exploration in acute pancreatitis. We utilized Mendelian randomization to assess the causal impact of folate, homocysteine, and vitamin B<jats:sub>12<\/jats:sub> (VB<jats:sub>12<\/jats:sub>) on acute pancreatitis. Wild\u2010type and corresponding genetically modified mouse models were used to verify the genetic correlating findings. A negative association between genetically predicted serum VB<jats:sub>12<\/jats:sub> levels and risks of acute pancreatitis was identified in human population. The transcobalamin receptor (TCblR)\/<jats:italic>CD320<\/jats:italic> gene ablation that decreased cellular VB<jats:sub>12<\/jats:sub> uptake and ATP production in pancreatic tissues promoted necrosis, resulting in much severe pathological changes of induced acute pancreatitis in mice. VB<jats:sub>12<\/jats:sub> pretreatment and posttreatment dramatically increased ATP levels in pancreatic tissues and reduced the necrosis, then the elevated levels of amylase in serum, the levels of CK\u201019, the activity of trypsin, and T lymphocyte infiltration in pancreatic tissues, prevented the pancreatic gross loss and ameliorated histopathological changes of mouse pancreases with induced acute pancreatitis. The results reveal that VB<jats:sub>12<\/jats:sub> is potential as a therapeutic agent to inhibit tissue injuries and adaptive inflammatory responses in the pancreas in patients with acute pancreatitis.<\/jats:p>","DOI":"10.1002\/mco2.686","type":"journal-article","created":{"date-parts":[[2024,10,16]],"date-time":"2024-10-16T06:51:11Z","timestamp":1729061471000},"source":"Crossref","is-referenced-by-count":5,"title":["Vitamin B<sub>12<\/sub> protects necrosis of acinar cells in pancreatic tissues with acute pancreatitis"],"prefix":"10.1002","volume":"5","author":[{"given":"Yulin","family":"Chen","sequence":"first","affiliation":[{"name":"West China Center of Excellence for Pancreatitis Institute of Integrated Traditional Chinese and Western Medicine Laboratory of Stem Cell Biology State Key Laboratory of Biotherapy West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8875-4760","authenticated-orcid":false,"given":"Xue","family":"Li","sequence":"additional","affiliation":[{"name":"West China Center of Excellence for Pancreatitis Institute of Integrated Traditional Chinese and Western Medicine Laboratory of Stem Cell Biology State Key Laboratory of Biotherapy West China Hospital, Sichuan University  Chengdu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ran","family":"Lu","sequence":"additional","affiliation":[{"name":"West China Center of Excellence for Pancreatitis Institute of Integrated Traditional Chinese and Western Medicine Laboratory of Stem Cell Biology State Key Laboratory of Biotherapy West China Hospital, Sichuan University  Chengdu China"},{"name":"Department of Occupational and Environmental Health West China School of Public Health and West China Fourth Hospital Sichuan University  Chengdu China"},{"name":"West China\u2010PUMC C.C. 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