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As effector cells, neutrophils promote autoimmune disease by releasing cytokines and chemokines cascades that accompany inflammation, neutrophil extracellular traps (NETs) regulating immune responses through cell\u2013cell interactions. More recent evidence has extended functions of neutrophils. Accumulating evidence implicated neutrophils contribute to tissue damage during a broad range of disorders, involving rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), primary sj\u00f6gren's syndrome (pSS), multiple sclerosis (MS), crohn's disease (CD), and gout. A variety of studies have reported on the functional role of neutrophils as therapeutic targets in autoimmune diseases. However, challenges and controversies in the field remain. Enhancing our understanding of neutrophils\u2019 role in autoimmune disorders may further advance the development of new therapeutic approaches.<\/jats:p>","DOI":"10.1002\/mco2.69","type":"journal-article","created":{"date-parts":[[2021,7,22]],"date-time":"2021-07-22T11:43:51Z","timestamp":1626954231000},"page":"402-413","source":"Crossref","is-referenced-by-count":76,"title":["The emerging role of neutrophils in autoimmune\u2010associated disorders: effector, predictor, and therapeutic targets"],"prefix":"10.1002","volume":"2","author":[{"given":"Xiaohong","family":"Fu","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, College of Basic Medical Science Third Military Medical University (Army Medical University)  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heting","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, College of Basic Medical Science 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