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The estimated 5\u2010 and 8\u2010year disease\u2010free survival (DFS) rates were similar in toremifene and AI groups: 96.5% versus 91.9%, and 87.4% versus 87.8% (<jats:italic>p\u00a0<\/jats:italic>=\u00a00.39), respectively. Adverse event rates were similar in two groups, except for a greater risk of endometrial thickening (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001) and a lower occurrence of morning stiffness (<jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001) in the toremifene compared to the AI group. Premenopausal HR\u2010positive breast cancer patients receiving toremifene plus OFS had better role physical and mental health outcomes and lower AD dimensions than those receiving AI plus OFS. 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