{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T00:54:45Z","timestamp":1790038485244,"version":"4.0.1"},"reference-count":31,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,1,2]],"date-time":"2025-01-02T00:00:00Z","timestamp":1735776000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071883"],"award-info":[{"award-number":["82071883"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The left ventricular trabecular fractal dimension (LVTFD) derived from cardiac magnetic resonance reflects myocardial trabecular complexity, which is associated with cardiovascular disease risk. Baseline risk stratification of cancer therapy\u2013related cardiac dysfunction (CTRCD) in patients with breast cancer who received anthracycline is a very important clinical issue. In this study, we used the Cox model to derive and validate a new score system based on LVTFD for baseline risk stratification of CTRCD in breast cancer patients receiving anthracycline. We also compare the performance of LVTFD\u2010based score with the Heart Failure Association\u2010International Cardio\u2010Oncology Society (HFA\u2010ICOS) score using C\u2010index. This study enrolled 370 participants, of whom 73 participants developed CTRCD. The C\u2010indices of LVTFD\u2010based score integrating age, hypertension, previous cardiovascular disease, and maximal apical fractal dimension were higher than those of HFA\u2010ICOS score for stratifying CTRCD (0.834 vs. 0.642 and 0.834 vs. 0.633, respectively, in derivation and validation cohort). LVTFD\u2010based score can stratify the CTRCD risk, but HFA\u2010ICOS score cannot. The above results reveal that the LVTFD\u2010based score is an alternative method for baseline risk stratification of CTRCD in breast cancer who received anthracycline.<\/jats:p>","DOI":"10.1002\/mco2.70004","type":"journal-article","created":{"date-parts":[[2025,1,3]],"date-time":"2025-01-03T00:08:08Z","timestamp":1735862888000},"source":"Crossref","is-referenced-by-count":4,"title":["Left ventricular trabecular complexity for risk stratification of cancer therapy\u2013related cardiac dysfunction in breast cancer"],"prefix":"10.1002","volume":"6","author":[{"given":"Hesong","family":"Shen","sequence":"first","affiliation":[{"name":"Department of Radiology Chongqing University Cancer Hospital &amp; Chongqing Cancer Institute &amp; Chongqing Cancer Hospital  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Medicine Chongqing University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunrong","family":"Tu","sequence":"additional","affiliation":[{"name":"Department of Radiology Chongqing University Cancer Hospital &amp; 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