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Tumors that commonly metastasize to the brain include lung cancer and breast cancer. In recent years, the prognosis for BM patients has improved, and significant advancements have been made in both clinical and preclinical research. This review focuses on BM originating from lung cancer and breast cancer. We briefly overview the history and epidemiology of BM, as well as the current diagnostic and treatment paradigms. Additionally, we summarize multiomics evidence on the mechanisms of tumor occurrence and development in the era of artificial intelligence and discuss the role of the tumor microenvironment. Preclinically, we introduce the establishment of BM models, detailed molecular mechanisms, and cutting\u2010edge treatment methods. BM is primarily treated with a comprehensive approach, including local treatments such as surgery and radiotherapy. For lung cancer, targeted therapy and immunotherapy have shown efficacy, while in breast cancer, monoclonal antibodies, tyrosine kinase inhibitors, and antibody\u2013drug conjugates are effective in BM. Multiomics approaches assist in clinical diagnosis and treatment, revealing the complex mechanisms of BM. Moreover, preclinical agents often need to cross the blood\u2013brain barrier to achieve high intracranial concentrations, including small\u2010molecule inhibitors, nanoparticles, and peptide drugs. Addressing BM is imperative.<\/jats:p>","DOI":"10.1002\/mco2.70020","type":"journal-article","created":{"date-parts":[[2024,12,20]],"date-time":"2024-12-20T21:34:11Z","timestamp":1734730451000},"source":"Crossref","is-referenced-by-count":17,"title":["Metastatic brain tumors: from development to cutting\u2010edge treatment"],"prefix":"10.1002","volume":"6","author":[{"given":"Guilong","family":"Tanzhu","sequence":"first","affiliation":[{"name":"Department of Oncology Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Oncology Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaoyang","family":"Ning","sequence":"additional","affiliation":[{"name":"Department of Oncology Xiangya Hospital Central South University  Changsha 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