{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T06:50:05Z","timestamp":1792651805882,"version":"4.5.0"},"reference-count":399,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T00:00:00Z","timestamp":1750809600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001411","name":"Indian Council of Medical Research","doi-asserted-by":"publisher","award":["IDNo.2022\u201016465"],"award-info":[{"award-number":["IDNo.2022\u201016465"]}],"id":[{"id":"10.13039\/501100001411","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Glutaminolysis, the metabolic process of converting glutamine into key intermediates, plays an essential role in cellular energy production, signaling, biosynthesis, and redox balance. Deregulation of glutamine metabolism significantly influences various pathological conditions, including cancers and metabolic and neurological diseases. Emerging evidence shows that long noncoding RNAs (lncRNAs), circular RNAs (circRNAs), and oncogenic alterations in glutamine transporters and enzymes enhance glutamine's role as an alternative energy source, supporting cell survival and proliferation under nutrient and oxygen deprivation conditions. To combat the pathogenic effects of altered glutamine metabolism, researchers are developing targeted inhibitors of key enzymes and transporters involved in glutaminolysis. By interfering with the mechanisms that support the growth of cancer cells, these inhibitors may be able to stop the growth of tumors and treat metabolic and neurological conditions. This review provides a comprehensive overview of existing inhibitors and ongoing clinical trials targeting glutamine metabolism, focusing on its potential as a cancer therapeutic strategy. Additionally, the role of lncRNAs and circRNAs in regulating glutamine metabolism is explored, revealing novel avenues for therapeutic intervention in cancer and other diseases.<\/jats:p>","DOI":"10.1002\/mco2.70120","type":"journal-article","created":{"date-parts":[[2025,6,25]],"date-time":"2025-06-25T03:51:11Z","timestamp":1750823471000},"source":"Crossref","is-referenced-by-count":48,"title":["Glutamine Metabolism: Molecular Regulation, Biological Functions, and Diseases"],"prefix":"10.1002","volume":"6","author":[{"given":"Mudasir A.","family":"Kumar","sequence":"first","affiliation":[{"name":"Watson\u2010Crick Centre for Molecular Medicine Islamic University of Science and Technology  Kashmir India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sana Khurshid","family":"Baba","sequence":"additional","affiliation":[{"name":"Watson\u2010Crick Centre for Molecular Medicine Islamic University of Science and Technology  Kashmir India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inamu Rashid","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Zoology School of Life Sciences Central University of Kashmir  Ganderbal India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohd Shahnawaz","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Biochemistry College of Sciences King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fohad Mabood","family":"Husain","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition College of Food and Agriculture Sciences King Saud University  Riyadh Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saheem","family":"Ahmad","sequence":"additional","affiliation":[{"name":"Department of Medical Laboratory Sciences College of Applied Medical Sciences University of Hail  Hail City Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad","family":"Haris","sequence":"additional","affiliation":[{"name":"Center for Advanced Metabolic Imaging in Precision Medicine Department of Radiology Perelman School of Medicine University of Pennsylvania  Philadelphia USA"},{"name":"Laboratory Animal Research Centre Qatar University  Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayank","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology (Lab.) 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