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RNA methylation is the predominant form of epigenetic regulation, and the most prevalent modification in RNA is N6\u2010methyladenosine (m<jats:sup>6<\/jats:sup>A). Recently, RNA modification has emerged as a potential target for disease treatment. RNA modification is a posttranscriptional gene expression regulation that is involved in both physiological and pathological processes. Evidence suggests that m<jats:sup>6<\/jats:sup>A methylation significantly affects RNA metabolism, and its abnormal changes have been observed in a variety of diseases. Metabolic diseases are a series of diseases caused by abnormal metabolic processes of the body, the common metabolic diseases include diabetes mellitus, obesity, and nonalcoholic fatty liver disease, etc.; although the pathogenesis of these diseases differs from each other to the current understanding, most recent studies suggested pivotal role m<jats:sup>6<\/jats:sup>A in modulating these metabolic diseases, and m<jats:sup>6<\/jats:sup>A\u2010based drug development has been on the agenda. This paper reviewed recent understanding of RNA modification in metabolic diseases, hoping to provide systematic information for those in this area.<\/jats:p>","DOI":"10.1002\/mco2.70135","type":"journal-article","created":{"date-parts":[[2025,3,11]],"date-time":"2025-03-11T15:25:31Z","timestamp":1741706731000},"source":"Crossref","is-referenced-by-count":8,"title":["RNA Modification in Metabolism"],"prefix":"10.1002","volume":"6","author":[{"given":"Yadi","family":"Liu","sequence":"first","affiliation":[{"name":"Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines Macau University of Science and Technology  Taipa Macao SAR PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhongyan","family":"Sun","sequence":"additional","affiliation":[{"name":"Faculty of Chinese Medicine, State Key Laboratory of Quality Research in Chinese Medicines Macau University of Science and Technology  Taipa Macao SAR PR 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