{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T07:08:33Z","timestamp":1790060913927,"version":"4.0.1"},"reference-count":53,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T00:00:00Z","timestamp":1787702400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Associations between various genetic variants and the risk of hepatocellular carcinoma (HCC) have been extensively explored but produced contradictory results. The aim of the present systematic meta\u2010analysis was to determine and validate genetic variants that are associated with HCC risk. Two\u2010step literature searches of PubMed, Embase, Web of Science, and Google Scholar databases and various meta\u2010analyses were performed, and a comprehensive field synopsis and epidemiological evidence were provided. A total of 20,081 publications were identified, of which 830 were deemed eligible for inclusion. Eventually, 36 variants in 27 genes were identified to be associated with HCC risk. Moreover, cumulative epidemiological evidence of an association was graded as moderate for nine variants in eight genes (\n                    <jats:italic>ESR1<\/jats:italic>\n                    rs2234693,\n                    <jats:italic>GRP78<\/jats:italic>\n                    rs430397,\n                    <jats:italic>HLA\u2010DP<\/jats:italic>\n                    rs3077,\n                    <jats:italic>HLA\u2010DQ<\/jats:italic>\n                    rs2856718,\n                    <jats:italic>MnSOD<\/jats:italic>\n                    rs4880,\n                    <jats:italic>TNF\u03b1<\/jats:italic>\n                    rs361525,\n                    <jats:italic>HFE<\/jats:italic>\n                    rs1800562 and rs1799945, and\n                    <jats:italic>UGT1A7<\/jats:italic>\n                    High\/Low) and strong for three variants in three genes (\n                    <jats:italic>IL\u20101B<\/jats:italic>\n                    rs1143627,\n                    <jats:italic>COL18A1<\/jats:italic>\n                    rs7499, and\n                    <jats:italic>NQO1<\/jats:italic>\n                    rs1800566);\n                    <jats:italic>HFE<\/jats:italic>\n                    rs1800562 was deemed to have a false\u2010positive association. Thus, 11 variants in 11 genes were identified to be associated with HCC risk. This synopsis helps elucidate the mechanisms of carcinogenesis of HCC and provides insights into the early diagnosis and novel treatments of HCC by targeting those potential genes.\n                  <\/jats:p>","DOI":"10.1002\/mco2.70153","type":"journal-article","created":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T07:20:58Z","timestamp":1787728858000},"source":"Crossref","is-referenced-by-count":0,"title":["Genetic Association Studies in Hepatocellular Carcinoma: Systematic Meta\u2010Analyses, a Comprehensive Field Synopsis, and Epidemiological Evidence"],"prefix":"10.1002","volume":"7","author":[{"given":"Yujin","family":"Shi","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education) Institute for Viral Hepatitis The Second Affiliated Hospital Chongqing Medical University  Chongqing 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