{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T15:31:53Z","timestamp":1793028713641,"version":"4.5.0"},"reference-count":430,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T00:00:00Z","timestamp":1749168000000},"content-version":"vor","delay-in-days":5,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013792","name":"Chengdu University","doi-asserted-by":"publisher","award":["2081921001"],"award-info":[{"award-number":["2081921001"]}],"id":[{"id":"10.13039\/501100013792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82260771"],"award-info":[{"award-number":["82260771"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The blood\u2013brain barrier (BBB) is a highly selective and protective barrier that restricts the entry of most therapeutic agents into the central nervous system (CNS), posing a significant challenge for the treatment of CNS diseases. The nose\u2010to\u2010brain drug delivery (NBDD) route has emerged as a promising strategy to bypass the BBB, offering direct, noninvasive, and efficient transport of drugs to the brain. This review begins with a concise overview of the BBB structure and its biofunctions, followed by an in\u2010depth discussion of the mechanisms underlying the nose\u2010to\u2010brain pathway, including the olfactory and trigeminal nerve routes, and respiratory pathway. We further highlight the therapeutic research development of neurodegenerative diseases, acute neurological diseases, brain tumor, and psychiatric disorders when using NBDD drugs encompassing small\u2010molecule drugs, proteins, peptides, nucleic acids, siRNA, and herbal compounds, in which we also introduce innovative delivery systems, including nanocarriers and novel platforms such as exosomes, which enhance drug stability, targeting efficiency, and bioavailability. In addition, we provide a comprehensive overview of recent clinical advancements in therapeutics delivered via the intranasal route for CNS diseases. Finally, we discuss the challenges and future directions of NBDD, emphasizing its potential to transform the treatment landscape for CNS disorders.<\/jats:p>","DOI":"10.1002\/mco2.70213","type":"journal-article","created":{"date-parts":[[2025,6,6]],"date-time":"2025-06-06T04:47:33Z","timestamp":1749185253000},"source":"Crossref","is-referenced-by-count":81,"title":["The Nasal\u2013Brain Drug Delivery Route: Mechanisms and Applications to Central Nervous System Diseases"],"prefix":"10.1002","volume":"6","author":[{"given":"Yi","family":"Qiu","sequence":"first","affiliation":[{"name":"Sichuan Industrial Institute of Antibiotics School of Pharmacy Chengdu University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Sichuan Industrial Institute of Antibiotics School of Pharmacy Chengdu University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology and Metabolism Shanghai Pudong Gongli Hospital Pudong New Area  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Technology Sichuan Youngster Technology Co., Ltd  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guosong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Jiangxi University of Traditional Chinese Medicine  Nanchang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Liu","sequence":"additional","affiliation":[{"name":"Sichuan Industrial Institute of Antibiotics School of Pharmacy Chengdu University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Geriatrics Geriatric Diseases Institute of Chengdu Chengdu Fifth People's Hospital  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xi","family":"Peng","sequence":"additional","affiliation":[{"name":"Sichuan Industrial Institute of Antibiotics School of Pharmacy Chengdu University  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,6,6]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(18)30468-X"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.12.009"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arr.2024.102242"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.05.011"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7395"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2023.1137096"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2023.104756"},{"key":"e_1_2_12_9_1","first-page":"255","volume-title":"International Review of Neurobiology","author":"Du L.","year":"2023"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2019.04.017"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-020-00747-y"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2024.115196"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2014.03.004"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2021.114849"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.09.001"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2023.104756"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2018.1378642"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.2174\/1389201021666201218130947"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16070929"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.124866"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-161256"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00050.2017"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.4155\/tde.15.32"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.2500\/ajra.2015.29.4149"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mattod.2020.02.001"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.05.019"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2013.790887"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2020.104952"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2020.12.002"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2016.08.025"},{"issue":"2","key":"e_1_2_12_31_1","first-page":"4441","article-title":"Zebularine Protects Against Blood\u2010brain\u2010barrier (BBB) Disruption Through Increasing the Expression of Zona Occludens\u20101 (ZO\u20101) and Vascular Endothelial (VE)\u2010cadherin","volume":"13","author":"Zeng X.","year":"2022","journal-title":"Bioengineering"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.122.036946"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567201816666190828153017"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-023-03955-3"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1039\/C5BM00383K"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-018-2982-x"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2023.10.034"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1517\/14728222.2015.1042364"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.conb.2018.12.014"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coche.2020.08.009"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1111\/cns.12405"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneurol.2017.188"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.03.020"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13365-023-01190-8"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3966"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.4155\/tde-2019-0006"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21093344"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.copbio.2019.01.013"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104795"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2023.1341295"},{"issue":"10","key":"e_1_2_12_51_1","first-page":"2070","article-title":"Application of Intranasal Administration in the Delivery of Antidepressant Active Ingredients","volume":"14","author":"Jin Z.","year":"2022","journal-title":"pharmacy"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.979682"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2017.05.001"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2015.09.023"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.09.047"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1214450"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2019.05.032"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2018.05.011"},{"issue":"11","key":"e_1_2_12_59_1","first-page":"1904","article-title":"Selective CNS Targeting and Distribution With a Refined Region\u2010specific Intranasal Delivery Technique via the Olfactory Mucosa","volume":"13","author":"Maigler F.","year":"2021","journal-title":"Pharmacy"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2021.103091"},{"issue":"13","key":"e_1_2_12_61_1","first-page":"2841","article-title":"Effect of N\u2010acetyl\u2010L\u2010cysteine on Bioavailability and Brain Distribution of Curcumin by Nasal Delivery","volume":"44","author":"Su W.","year":"2019","journal-title":"China Journal of Chinese Materia Medica"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.04.022"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40005-022-00589-5"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2017.12.025"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.23816"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2017.07.026"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2020.626882"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567201816666191029122740"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1461-5347(00)00302-3"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1002\/wnan.1767"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.114.216705"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2022.103569"},{"key":"e_1_2_12_73_1","first-page":"375","volume-title":"A Review: Nose to Brain Drug Delivery for Various CNS Disorders","author":"Jadhav S.","year":"2020"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.21254"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01780-w"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(00)00442-6"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2016.02.001"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1039\/D0NR07516G"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24043390"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.3c00588"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16060746"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15030746"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.07.044"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajps.2023.100778"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1080\/21691401.2017.1337024"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2024.114285"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2024.101057"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2021.102642"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2016.05.013"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics12070678"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2021.02.012"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.865590"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jgr.2023.07.005"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-024-01541-9"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2018.11.021"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2013.05.009"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111829"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-021-02096-0"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2021-0051"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00216-021-03487-1"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2023.122588"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-020-00754-z"},{"key":"e_1_2_12_103_1","first-page":"1","article-title":"Nanostructured Lipid Carriers of Donepezil Hydrochloride for the Treatment of Alzheimer's Disease","volume":"21","author":"Avinash T.","year":"2024","journal-title":"Current Alzheimer Research"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1080\/02652048.2020.1756971"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S417928"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.201902906"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.3390\/polym16040510"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40520-020-01646-5"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-022-03177-3"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-022-03624-x"},{"issue":"1","key":"e_1_2_12_111_1","first-page":"46","article-title":"Nanoparticulate Carrier Mediated Intranasal Delivery of Insulin for the Restoration of Memory Signaling in Alzheimer's Disease","volume":"9","author":"Pankaj D.","year":"2013","journal-title":"Current Nanoscience"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8249(200010)48:4<567::AID-ANA3>3.0.CO;2-W"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.3c08756"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2017.01.031"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.103596"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.125125"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0500195102"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-151121"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202203182"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12906-023-04125-2"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.24557"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2023.123387"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1224856"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1096\/fasebj.2020.34.s1.08639"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.121244"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S369978"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S151474"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-019-1513-x"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2024.01.013"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c06215"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.119115"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14051003"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S339979"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2021.111838"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1080\/10837450.2020.1740257"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1002\/adfm.202411426"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.3109\/03639045.2014.991400"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.3109\/10611860903386938"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2020.101954"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2017.12.056"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2020.101791"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2012.12.007"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2022.103923"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.119148"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2021.102377"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1080\/10826076.2017.1343735"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2019.1636420"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1159\/000445871"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-90094-w"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2024.04.010"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-019-04883-8"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.02.033"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.05.020"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/2382563"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.3390\/brainsci9100275"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2022.113065"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1080\/03639045.2019.1576724"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/nlz128"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.134908"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2022.103518"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-024-03745-8"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2024.134144"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12640-022-00556-w"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.1002\/cbin.11250"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2020.101792"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.107207"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep41768"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2020.11.019"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2024.124237"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.1039\/D2BM00518B"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25074047"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2022.12.026"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2023.123351"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2019.102119"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.3109\/10717544.2014.880860"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14122590"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-024-02764-2"},{"key":"e_1_2_12_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2008.08.073"},{"key":"e_1_2_12_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2017.07.005"},{"key":"e_1_2_12_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2021.121311"},{"key":"e_1_2_12_181_1","doi-asserted-by":"publisher","DOI":"10.1002\/acn3.51885"},{"key":"e_1_2_12_182_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.214"},{"key":"e_1_2_12_183_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.058503"},{"key":"e_1_2_12_184_1","doi-asserted-by":"publisher","DOI":"10.3109\/10717544.2016.1153748"},{"key":"e_1_2_12_185_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-021-00940-7"},{"key":"e_1_2_12_186_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.064386"},{"key":"e_1_2_12_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2023.121398"},{"key":"e_1_2_12_188_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40263-020-00781-x"},{"key":"e_1_2_12_189_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.11.037"},{"key":"e_1_2_12_190_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e33657"},{"key":"e_1_2_12_191_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaneurol.2020.1840"},{"key":"e_1_2_12_192_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-022-05165-3"},{"key":"e_1_2_12_193_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm840"},{"key":"e_1_2_12_194_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-023-02873-z"},{"key":"e_1_2_12_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2021.147517"},{"key":"e_1_2_12_196_1","doi-asserted-by":"publisher","DOI":"10.2174\/1567201813666160607123409"},{"key":"e_1_2_12_197_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X20666220507022701"},{"key":"e_1_2_12_198_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1109-6"},{"key":"e_1_2_12_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2011.02.022"},{"key":"e_1_2_12_200_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c08473"},{"key":"e_1_2_12_201_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.9b06453"},{"key":"e_1_2_12_202_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aav7188"},{"issue":"2","key":"e_1_2_12_203_1","article-title":"Histological Study on the Protective Role of Intranasally Applied Adipose\u2010Derived Mesenchymal Stem Cells on Demyelinated Corpus Callosum in a Mouse Model of Multiple Sclerosis","volume":"117","author":"Rahman Ahmed Mekawy M. A. E.","year":"2024","journal-title":"QJM: An International Journal of Medicine"},{"key":"e_1_2_12_204_1","doi-asserted-by":"publisher","DOI":"10.1002\/glia.23896"},{"key":"e_1_2_12_205_1","doi-asserted-by":"publisher","DOI":"10.15171\/apb.2018.066"},{"key":"e_1_2_12_206_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X18666200522201123"},{"issue":"1","key":"e_1_2_12_207_1","first-page":"A97","article-title":"L22\u2005Intranasal Application of NPY and NPY13\u201336 Ameliorate Disease Pathology in R6\/2 Mouse Model of huntington's Disease","volume":"87","author":"Fatoba O.","year":"2016","journal-title":"Journal of Neurology, Neurosurgery & Psychiatry"},{"key":"e_1_2_12_208_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.06.002"},{"key":"e_1_2_12_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2020.108038"},{"key":"e_1_2_12_210_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2023.123748"},{"key":"e_1_2_12_211_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2021.108760"},{"key":"e_1_2_12_212_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.149807"},{"key":"e_1_2_12_213_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-020-00884-9"},{"key":"e_1_2_12_214_1","doi-asserted-by":"publisher","DOI":"10.7150\/ntno.99825"},{"key":"e_1_2_12_215_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12868-022-00732-w"},{"key":"e_1_2_12_216_1","doi-asserted-by":"publisher","DOI":"10.2174\/011574888X290104240320041613"},{"key":"e_1_2_12_217_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12868-018-0418-z"},{"key":"e_1_2_12_218_1","doi-asserted-by":"publisher","DOI":"10.3727\/096368912X657251"},{"key":"e_1_2_12_219_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2020.113542"},{"key":"e_1_2_12_220_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0312298"},{"key":"e_1_2_12_221_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222312860"},{"key":"e_1_2_12_222_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12668-023-01072-7"},{"key":"e_1_2_12_223_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-01862-x"},{"key":"e_1_2_12_224_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16020290"},{"key":"e_1_2_12_225_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-022-02903-6"},{"key":"e_1_2_12_226_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2016.05.037"},{"key":"e_1_2_12_227_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2020.1760960"},{"key":"e_1_2_12_228_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2022.2104405"},{"key":"e_1_2_12_229_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2022.120797"},{"key":"e_1_2_12_230_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-021-09766-x"},{"key":"e_1_2_12_231_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11302-015-9489-9"},{"key":"e_1_2_12_232_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nano.2018.10.013"},{"key":"e_1_2_12_233_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-33296-z"},{"key":"e_1_2_12_234_1","doi-asserted-by":"publisher","DOI":"10.1177\/1759091415605114"},{"key":"e_1_2_12_235_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-016-0034-9"},{"key":"e_1_2_12_236_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.314320"},{"key":"e_1_2_12_237_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-014-8984-2"},{"key":"e_1_2_12_238_1","doi-asserted-by":"publisher","DOI":"10.1161\/str.32.suppl_1.352"},{"key":"e_1_2_12_239_1","doi-asserted-by":"publisher","DOI":"10.3109\/10717544.2011.557785"},{"key":"e_1_2_12_240_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2023.03.033"},{"key":"e_1_2_12_241_1","doi-asserted-by":"publisher","DOI":"10.4062\/biomolther.2016.050"},{"key":"e_1_2_12_242_1","doi-asserted-by":"publisher","DOI":"10.1134\/S1819712421010153"},{"issue":"1","key":"e_1_2_12_243_1","first-page":"79","article-title":"Prophylactic Effect of Intranasal Oxytocin on Brain Damage and Neurological Disorders in Global Cerebral Ischemia in Mice","volume":"24","author":"Saffari M.","year":"2021","journal-title":"Iranian Journal of Basic Medical Sciences"},{"key":"e_1_2_12_244_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-015-9854-1"},{"key":"e_1_2_12_245_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2008.09.030"},{"key":"e_1_2_12_246_1","doi-asserted-by":"publisher","DOI":"10.1179\/1743132810Y.0000000004"},{"key":"e_1_2_12_247_1","doi-asserted-by":"publisher","DOI":"10.3892\/br.2020.1347"},{"key":"e_1_2_12_248_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.07.008"},{"key":"e_1_2_12_249_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2023.137366"},{"key":"e_1_2_12_250_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2021.103059"},{"key":"e_1_2_12_251_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.npep.2021.102182"},{"key":"e_1_2_12_252_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.585082"},{"key":"e_1_2_12_253_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-023-03739-4"},{"key":"e_1_2_12_254_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202200456RR"},{"key":"e_1_2_12_255_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-014-0208-9"},{"key":"e_1_2_12_256_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22189999"},{"key":"e_1_2_12_257_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.2352-17.2018"},{"key":"e_1_2_12_258_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.105760"},{"key":"e_1_2_12_259_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X17702669"},{"key":"e_1_2_12_260_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114542"},{"key":"e_1_2_12_261_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-021-10025-4"},{"key":"e_1_2_12_262_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X20938137"},{"key":"e_1_2_12_263_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2016.03.019"},{"key":"e_1_2_12_264_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S458656"},{"key":"e_1_2_12_265_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules27217644"},{"key":"e_1_2_12_266_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S343928"},{"issue":"05","key":"e_1_2_12_267_1","first-page":"688","article-title":"Feasibility of Nasal Brain Targeted Drug Delivery Through the Nose\u2010brain Channel in the Nasal Olfactory Region Using Cimicifugoside H\u20101","volume":"20","author":"Wu M.","year":"2016","journal-title":"Chinese Journal of Tissue Engineering Research"},{"key":"e_1_2_12_268_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e32592"},{"key":"e_1_2_12_269_1","doi-asserted-by":"publisher","DOI":"10.1111\/jphp.12797"},{"key":"e_1_2_12_270_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S265659"},{"key":"e_1_2_12_271_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2016.06.001"},{"issue":"12","key":"e_1_2_12_272_1","first-page":"2481","article-title":"Effect of Salvianolic Acid B by Intranasal Administration on Cognitive Function and Neurogenesis of Cerebral Ischemia Rats","volume":"48","author":"Ju A.","year":"2017","journal-title":"Chinese Traditional and Herbal Drugs"},{"key":"e_1_2_12_273_1","doi-asserted-by":"publisher","DOI":"10.1055\/a-0596-7288"},{"issue":"4","key":"e_1_2_12_274_1","article-title":"Evaluation of the Effect of Intranasal Lidocaine in the Treatment of Spasticity in Patients With Traumatic Brain Injury","volume":"11","author":"Dehnadi Moghadam A.","year":"2021","journal-title":"Anesthesia and Pain Medicine"},{"key":"e_1_2_12_275_1","doi-asserted-by":"publisher","DOI":"10.1254\/jpssuppl.WCP2018.0_PO2-1-18"},{"key":"e_1_2_12_276_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.14036"},{"key":"e_1_2_12_277_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106238"},{"key":"e_1_2_12_278_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-44426-7"},{"key":"e_1_2_12_279_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2023.1185883"},{"key":"e_1_2_12_280_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2021.105173"},{"key":"e_1_2_12_281_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-47627-2"},{"key":"e_1_2_12_282_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-024-01072-z"},{"key":"e_1_2_12_283_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2014.06.037"},{"key":"e_1_2_12_284_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16056"},{"key":"e_1_2_12_285_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X16685106"},{"key":"e_1_2_12_286_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2023.08.009"},{"key":"e_1_2_12_287_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-024-02769-5"},{"key":"e_1_2_12_288_1","doi-asserted-by":"publisher","DOI":"10.1111\/head.13248"},{"key":"e_1_2_12_289_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells11081348"},{"key":"e_1_2_12_290_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awab205"},{"key":"e_1_2_12_291_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16060774"},{"key":"e_1_2_12_292_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2017.00039"},{"key":"e_1_2_12_293_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2011.2228"},{"key":"e_1_2_12_294_1","doi-asserted-by":"publisher","DOI":"10.1089\/neu.2016.4871"},{"key":"e_1_2_12_295_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24405"},{"key":"e_1_2_12_296_1","doi-asserted-by":"publisher","DOI":"10.1177\/0271678X211028680"},{"key":"e_1_2_12_297_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12112555"},{"key":"e_1_2_12_298_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-180871"},{"key":"e_1_2_12_299_1","doi-asserted-by":"publisher","DOI":"10.1080\/1061186x.2021.2023159"},{"key":"e_1_2_12_300_1","doi-asserted-by":"publisher","DOI":"10.1155\/2017\/5819514"},{"key":"e_1_2_12_301_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.033272"},{"key":"e_1_2_12_302_1","doi-asserted-by":"publisher","DOI":"10.1134\/S0006297923030070"},{"key":"e_1_2_12_303_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.314320"},{"key":"e_1_2_12_304_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2022.107479"},{"key":"e_1_2_12_305_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2018.06.006"},{"key":"e_1_2_12_306_1","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.354513"},{"key":"e_1_2_12_307_1","doi-asserted-by":"publisher","DOI":"10.1080\/02699052.2017.1376760"},{"issue":"18","key":"e_1_2_12_308_1","first-page":"4302","article-title":"Intranasal human\u2010recombinant Nerve Growth Factor Administration Improves Cognitive Functions in a Child With Severe Traumatic Brain Injury","volume":"28","author":"Capossela L.","year":"2024","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_12_309_1","doi-asserted-by":"publisher","DOI":"10.1080\/1061186X.2021.2023159"},{"key":"e_1_2_12_310_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00183"},{"key":"e_1_2_12_311_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.10.063"},{"key":"e_1_2_12_312_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2016.01.043"},{"key":"e_1_2_12_313_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.08.210"},{"key":"e_1_2_12_314_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12668-024-01521-x"},{"key":"e_1_2_12_315_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2022.121563"},{"key":"e_1_2_12_316_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2019.02.013"},{"key":"e_1_2_12_317_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2023.116754"},{"key":"e_1_2_12_318_1","doi-asserted-by":"publisher","DOI":"10.1080\/1061186X.2019.1706095"},{"key":"e_1_2_12_319_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-020-01805-x"},{"key":"e_1_2_12_320_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-024-03536-3"},{"key":"e_1_2_12_321_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2019.07.033"},{"key":"e_1_2_12_322_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics16091125"},{"key":"e_1_2_12_323_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2024.114326"},{"key":"e_1_2_12_324_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.120250"},{"key":"e_1_2_12_325_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1NR05460K"},{"key":"e_1_2_12_326_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.0c00911"},{"key":"e_1_2_12_327_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.965789"},{"key":"e_1_2_12_328_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2024.106390"},{"key":"e_1_2_12_329_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.2c00083"},{"key":"e_1_2_12_330_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2024.11.030"},{"key":"e_1_2_12_331_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2023-0131"},{"key":"e_1_2_12_332_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14030631"},{"key":"e_1_2_12_333_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msec.2016.03.015"},{"key":"e_1_2_12_334_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2015.188"},{"key":"e_1_2_12_335_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2021.10.042"},{"key":"e_1_2_12_336_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2016.02.032"},{"key":"e_1_2_12_337_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-01279-1"},{"key":"e_1_2_12_338_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.11.013"},{"key":"e_1_2_12_339_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119342"},{"key":"e_1_2_12_340_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.1c07587"},{"key":"e_1_2_12_341_1","doi-asserted-by":"publisher","DOI":"10.1038\/mt.2013.199"},{"key":"e_1_2_12_342_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stemcr.2016.07.024"},{"key":"e_1_2_12_343_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1NR03455C"},{"key":"e_1_2_12_344_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-019-2662-z"},{"key":"e_1_2_12_345_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph5101092"},{"key":"e_1_2_12_346_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2022.122142"},{"key":"e_1_2_12_347_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.bioconjchem.4c00300"},{"key":"e_1_2_12_348_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2023.08.018"},{"key":"e_1_2_12_349_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2018.03.055"},{"key":"e_1_2_12_350_1","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2022.2139370"},{"key":"e_1_2_12_351_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2023.105149"},{"key":"e_1_2_12_352_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.vascn.2024.107519"},{"key":"e_1_2_12_353_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-85293-4"},{"key":"e_1_2_12_354_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.9b01215"},{"key":"e_1_2_12_355_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms241411722"},{"key":"e_1_2_12_356_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jare.2023.01.005"},{"key":"e_1_2_12_357_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-017-0605-2"},{"key":"e_1_2_12_358_1","doi-asserted-by":"publisher","DOI":"10.1200\/jco.2010.28.15_suppl.2098"},{"key":"e_1_2_12_359_1","doi-asserted-by":"publisher","DOI":"10.1093\/noajnl\/vdab005"},{"key":"e_1_2_12_360_1","doi-asserted-by":"publisher","DOI":"10.3171\/2018.11.JNS181161"},{"key":"e_1_2_12_361_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2012.08.022"},{"key":"e_1_2_12_362_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-022-01220-8"},{"key":"e_1_2_12_363_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.30398"},{"key":"e_1_2_12_364_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2024.1463976"},{"key":"e_1_2_12_365_1","first-page":"1","article-title":"Nanosystems for Intranasal Delivery of Therapeutics in Psychiatric Disorders","volume":"22","author":"Samin H.","year":"2025","journal-title":"Current Drug Delivery"},{"key":"e_1_2_12_366_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2024.105800"},{"key":"e_1_2_12_367_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2023.104974"},{"key":"e_1_2_12_368_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.colsurfb.2019.05.016"},{"key":"e_1_2_12_369_1","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S102500"},{"key":"e_1_2_12_370_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2017.1357148"},{"key":"e_1_2_12_371_1","doi-asserted-by":"publisher","DOI":"10.22270\/jddt.v9i1-s.2274"},{"key":"e_1_2_12_372_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2024.08.026"},{"key":"e_1_2_12_373_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xphs.2024.11.019"},{"key":"e_1_2_12_374_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2016.03.008"},{"key":"e_1_2_12_375_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2012.02.051"},{"key":"e_1_2_12_376_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpsychires.2013.10.011"},{"key":"e_1_2_12_377_1","doi-asserted-by":"publisher","DOI":"10.1080\/10837450.2024.2376067"},{"key":"e_1_2_12_378_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2016.12.003"},{"key":"e_1_2_12_379_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2014.05.004"},{"key":"e_1_2_12_380_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12249-019-1484-y"},{"key":"e_1_2_12_381_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S277352"},{"key":"e_1_2_12_382_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpb.2023.12.002"},{"key":"e_1_2_12_383_1","doi-asserted-by":"publisher","DOI":"10.1088\/0957-4484\/27\/2\/025102"},{"key":"e_1_2_12_384_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4NR04250F"},{"key":"e_1_2_12_385_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.089764"},{"key":"e_1_2_12_386_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2024.105947"},{"key":"e_1_2_12_387_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2014.61"},{"key":"e_1_2_12_388_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2017.09.022"},{"key":"e_1_2_12_389_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mehy.2012.04.045"},{"key":"e_1_2_12_390_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.202358"},{"key":"e_1_2_12_391_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2016.09.054"},{"key":"e_1_2_12_392_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2016.11.013"},{"key":"e_1_2_12_393_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jconrel.2021.06.007"},{"key":"e_1_2_12_394_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep22404"},{"key":"e_1_2_12_395_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S227598"},{"key":"e_1_2_12_396_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S369412"},{"key":"e_1_2_12_397_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-022-01337-1"},{"key":"e_1_2_12_398_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-010-0183-6"},{"key":"e_1_2_12_399_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-023-03974-0"},{"key":"e_1_2_12_400_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10517-022-05389-3"},{"key":"e_1_2_12_401_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-023-06336-4"},{"key":"e_1_2_12_402_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202402219"},{"key":"e_1_2_12_403_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2021.1986604"},{"key":"e_1_2_12_404_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2020.119550"},{"key":"e_1_2_12_405_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2021.109816"},{"key":"e_1_2_12_406_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matdes.2022.110597"},{"key":"e_1_2_12_407_1","doi-asserted-by":"publisher","DOI":"10.1039\/C9BM02006C"},{"key":"e_1_2_12_408_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijpharm.2021.120667"},{"key":"e_1_2_12_409_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15082095"},{"key":"e_1_2_12_410_1","doi-asserted-by":"publisher","DOI":"10.1080\/13880209.2020.1855213"},{"key":"e_1_2_12_411_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2024.106417"},{"key":"e_1_2_12_412_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2013.11.007"},{"key":"e_1_2_12_413_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-024-02879-y"},{"key":"e_1_2_12_414_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-020-00649-7"},{"key":"e_1_2_12_415_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsabm.0c00831"},{"key":"e_1_2_12_416_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbad172"},{"key":"e_1_2_12_417_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.751321"},{"key":"e_1_2_12_418_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2014.08.007"},{"key":"e_1_2_12_419_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-02150-4"},{"key":"e_1_2_12_420_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-27665-6"},{"key":"e_1_2_12_421_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-015-9724-x"},{"key":"e_1_2_12_422_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2023.105007"},{"key":"e_1_2_12_423_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-019-2613-8"},{"key":"e_1_2_12_424_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15010233"},{"key":"e_1_2_12_425_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-0587-9"},{"key":"e_1_2_12_426_1","doi-asserted-by":"publisher","DOI":"10.1517\/17425247.2011.566267"},{"key":"e_1_2_12_427_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics13071079"},{"key":"e_1_2_12_428_1","doi-asserted-by":"publisher","DOI":"10.2174\/138920112803341752"},{"key":"e_1_2_12_429_1","doi-asserted-by":"publisher","DOI":"10.1080\/10717544.2020.1837291"},{"key":"e_1_2_12_430_1","doi-asserted-by":"publisher","DOI":"10.3109\/03639045.2015.1052081"},{"key":"e_1_2_12_431_1","doi-asserted-by":"publisher","DOI":"10.2174\/1381612821666150923095958"}],"container-title":["MedComm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.70213","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,8,5]],"date-time":"2025-08-05T12:24:11Z","timestamp":1754396651000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mco2.70213"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,6]]},"references-count":430,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,6]]}},"alternative-id":["10.1002\/mco2.70213"],"URL":"https:\/\/doi.org\/10.1002\/mco2.70213","archive":["Portico"],"relation":{},"ISSN":["2688-2663","2688-2663"],"issn-type":[{"value":"2688-2663","type":"print"},{"value":"2688-2663","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,6]]},"article-number":"e70213"}}