{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:34:15Z","timestamp":1790354055804,"version":"4.1.0"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20231118"],"award-info":[{"award-number":["BK20231118"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Significant liver fibrosis is an indication for antiviral therapy in chronic hepatitis B (CHB). Using liver histology assessed by Scheuer system, we evaluated the diagnostic performance of PRO\u2010C3, GP73, and their combination for the presence of liver fibrosis, and compared them with FIB\u20104, APRI, Agile 3+, FAST, and LSM in treatment\u2010na\u00efve CHB patients from two centers. The study included 324 patients, of whom 167 had S2\u20134 (significant fibrosis) and 83 had S3\u20134 (advanced fibrosis). PRO\u2010C3 levels were higher in those with S2\u20134 and S3\u20134 compared with S0\u20131 and S0\u20132 (both <jats:italic>p\u00a0<\/jats:italic>&lt;\u00a00.001), with similar findings for GP73. PRO\u2010C3 and GP73 were independently associated with S2\u20134 and S3\u20134 in multivariable analyses. The area under the curves (AUCs) of PRO\u2010C3 for S2\u20134 and S3\u20134 were 0.81 and 0.80, respectively, and exceeded those of GP73 (0.75 and 0.73). The combination of PRO\u2010C3 and GP73 also had significantly higher AUCs for both S2\u20134 (0.84\u00a0vs. 0.64) and S3\u20134 (0.80\u00a0vs. 0.65) as compared with FIB\u20104, with similar findings for APRI, GP73, LSM, FAST, and Agile 3+ for S2\u20134. In conclusion, PRO\u2010C3 alone or in combination with GP73 is highly predictive for detecting significant liver fibrosis among CHB patients.<\/jats:p>","DOI":"10.1002\/mco2.70236","type":"journal-article","created":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T04:10:55Z","timestamp":1749615055000},"source":"Crossref","is-referenced-by-count":1,"title":["Superior Diagnostic Efficacy of N\u2010Terminal Propeptide of Type III Collagen and Golgi Protein 73 for Detection of Fibrosis in Chronic Hepatitis B Patients"],"prefix":"10.1002","volume":"6","author":[{"given":"Qianqian","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Infectious Diseases Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine Nanjing Jiangsu China"},{"name":"Department of Gastroenterology the Affiliated Huai'an Hospital of Xuzhou Medical University and Huai'an Second People's Hospital Huai'an Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4984-2631","authenticated-orcid":false,"given":"Ming\u2010Hua","family":"Zheng","sequence":"additional","affiliation":[{"name":"MAFLD Research Center Department of Hepatology the First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang China"},{"name":"Key Laboratory of Diagnosis and Treatment for the Development of Chronic Liver Disease in Zhejiang Province Wenzhou Zhejiang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0953-5912","authenticated-orcid":false,"given":"Li","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Hepatology the Fifth People's Hospital of Suzhou Suzhou Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fajuan","family":"Rui","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Ni","sequence":"additional","affiliation":[{"name":"Department of Infectious Diseases Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yali","family":"Xiong","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing Jiangsu China"},{"name":"Institute of Viruses and Infectious Diseases Nanjing University Nanjing Jiangsu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Infectious Disease Nanjing Drum Tower Hospital Affiliated Hospital of Medical School Nanjing University Nanjing Jiangsu 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