{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,15]],"date-time":"2025-08-15T01:55:44Z","timestamp":1755222944998,"version":"3.43.0"},"reference-count":71,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,6,11]],"date-time":"2025-06-11T00:00:00Z","timestamp":1749600000000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2022YFC2702400"],"award-info":[{"award-number":["2022YFC2702400"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202894","82201850","82288102"],"award-info":[{"award-number":["82202894","82201850","82288102"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2025,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:p>Menstruation is a key indicator of female reproductive health, yet clinical features and underlying mechanisms associated with menstrual changes following the coronavirus disease 2019 (COVID\u201019) infection remain unclear. Here, we recruited 253 participants through questionnaires, and 73 individuals underwent metabolomic analysis of blood serum. Over 60% reported menstrual changes, primarily experiencing longer cycle and lighter bleeding, which were significantly associated with age, general medical conditions, perceived stress, anxiety scores, and depression scores, as well as COVID\u201019 symptoms including fatigue and headache. General medical conditions were the sole independent risk factor for any menstrual changes. Metabolomic analysis highlighted disturbances in steroid hormone biosynthesis. We identified 52 significantly differential metabolites between groups with and without any menstrual changes (AnyC vs. NoC), with high discrimination achieved by combining phenylglyoxylic acid, PC O\u201040, traumatic acid, and estrone sulfate. Furthermore, several significantly upregulated metabolites were closely correlated with estradiol (E<jats:sub>2<\/jats:sub>) levels, including estrone sulfate, which was also positively correlated with T levels. Specifically, T levels decreased with recovery duration in the AnyC group (<jats:italic>p<\/jats:italic> = 0.0015). Collectively, our findings uncovered key clinical factors and metabolic disruptions in menstrual changes, underscoring potential adverse long\u2010term effects of COVID\u201019 on women's health.<\/jats:p>","DOI":"10.1002\/mco2.70240","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T10:57:49Z","timestamp":1749725869000},"source":"Crossref","is-referenced-by-count":0,"title":["The Clinical and Metabolic Profiles in Menstrual Changes Among Reproductive\u2010Aged Women Post\u2010COVID\u201019"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8136-3158","authenticated-orcid":false,"given":"Wei","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University Third Hospital  Beijing China"},{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital)  Beijing 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Obstetrics and Gynecology Peking University Third Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongxia","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University Third Hospital  Beijing China"},{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital)  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaole","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University Third Hospital  Beijing China"},{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital)  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juyan","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University Third Hospital  Beijing 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University Third Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuanyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital)  Beijing China"},{"name":"Center for Reproductive Medicine, Department of Obstetrics and Gynecology Peking University Third Hospital  Beijing China"},{"name":"State Key Laboratory of Female Fertility Promotion, Department of Obstetrics and Gynecology Peking University Third Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liying","family":"Yan","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital)  Beijing China"},{"name":"Center for Reproductive Medicine, Department of Obstetrics and Gynecology Peking University Third Hospital  Beijing China"},{"name":"State Key Laboratory of Female Fertility Promotion, Department of Obstetrics and Gynecology Peking University Third Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rong","family":"Li","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital)  Beijing China"},{"name":"Center for Reproductive Medicine, Department of Obstetrics and Gynecology Peking University Third Hospital  Beijing China"},{"name":"State Key Laboratory of Female Fertility Promotion, Department of Obstetrics and Gynecology Peking University Third Hospital  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University Third Hospital  Beijing China"},{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital)  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Qiao","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University Third Hospital  Beijing China"},{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital)  Beijing China"},{"name":"Center for Reproductive Medicine, Department of Obstetrics and Gynecology Peking University Third Hospital  Beijing China"},{"name":"State Key Laboratory of Female Fertility Promotion, Department of Obstetrics and Gynecology Peking University Third Hospital  Beijing China"},{"name":"Beijing Advanced Innovation Center for Genomics  Beijing 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