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This review synthesizes current evidence concerning the molecular mechanisms, therapeutic efficacy, and safety profile of RES across a variety of pathologies, with an emphasis on the latest research conducted in recent years. Mechanistically, RES is known to modulate critical signaling pathways such as the activation of sirtuin 1. These actions collectively contribute to the attenuation of oxidative stress, regulation of apoptosis, and promotion of autophagy. Preclinical studies have demonstrated the potential of RES in the mitigation of degenerative musculoskeletal disorders, cardiovascular diseases, cancer progression, and neurological diseases. Given the low bioavailability of RES and the potential for adverse reactions in clinical applications, we summarize and discuss its safety profile while outlining future research directions. This review underscores the therapeutic versatility of RES while advocating for rigorous pharmacokinetic optimization, standardized dosing protocols, and large\u2010scale randomized controlled trials to validate its efficacy and safety in human populations.<\/jats:p>","DOI":"10.1002\/mco2.70252","type":"journal-article","created":{"date-parts":[[2025,6,12]],"date-time":"2025-06-12T10:57:49Z","timestamp":1749725869000},"source":"Crossref","is-referenced-by-count":79,"title":["Resveratrol: Molecular Mechanisms, Health Benefits, and Potential Adverse Effects"],"prefix":"10.1002","volume":"6","author":[{"given":"Zhuo\u2010qun","family":"Ren","sequence":"first","affiliation":[{"name":"Department of Orthopedics Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"National Clinical Research Center for Geriatric Disorders Xiangya Hospital Central South University  Changsha Hunan China"},{"name":"Department of Clinical Medicine Xiangya Medicine School, Central South 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