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Affecting approximately 10% of the global population, these diseases impose significant health and economic burdens worldwide. The pathogenesis of autoimmune diseases is complex, involving not only genetic predisposition (e.g., human leukocyte antigen\u00a0variants), environmental triggers (e.g., infections), and a dysregulated immune response but also various interacting components that contribute to the development of diverse clinical phenotypes. This review provides a comprehensive overview of common autoimmune diseases, covering their clinical manifestations, pathogenic mechanisms, and diagnostic approaches such as disease\u2010specific autoantibodies. We also explore current therapeutic strategies, including commonly used broad\u2010spectrum anti\u2010inflammatory drugs, recent molecular\u2010targeted therapies (e.g., Janus kinase inhibitors, monoclonal antibodies), and emerging cellular therapies such as chimeric antigen receptor T cells therapy and regulatory T\u2010cell adoptive transfer. Incorporating knowledge from preclinical and clinical studies, this review synthesizes relevant information to inform about autoimmune diseases, bridge the gap from lab to clinic, and promote future advances through exploring precision medicine applications to meet clinical needs.<\/jats:p>","DOI":"10.1002\/mco2.70262","type":"journal-article","created":{"date-parts":[[2025,6,17]],"date-time":"2025-06-17T02:51:23Z","timestamp":1750128683000},"source":"Crossref","is-referenced-by-count":65,"title":["Autoimmune Diseases: Molecular Pathogenesis and Therapeutic Targets"],"prefix":"10.1002","volume":"6","author":[{"given":"Xiaoshuang","family":"Song","sequence":"first","affiliation":[{"name":"Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center of Biotherapy West China Hospital Sichuan University  Chengdu Sichuan China"},{"name":"Center for Immunology and Hematology Department of Biotherapy and Cancer Center and State Key Laboratory of Biotherapy West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hantian","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center of Biotherapy West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Nan","sequence":"additional","affiliation":[{"name":"Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center of Biotherapy West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjing","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center of Biotherapy West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center of Biotherapy West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liu","family":"He","sequence":"additional","affiliation":[{"name":"Department of Biotherapy, State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center of Biotherapy West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiping","family":"Cun","sequence":"additional","affiliation":[{"name":"Department of Immunology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences; 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