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In this study, the Lineage IV LASV strain was successfully isolated from the first imported case in China. Compared with the LASV genome, the isolated strain may exhibit greater infectivity and interspecies transmission capabilities. We successfully established BALB\/c, C57BL\/6, and AG129 mouse infection models and found that intranasal inoculation was the most stable infection method. Select the anti\u2010LASV drug LHF\u2010535 for preliminary evaluation, further confirming the stability of the model. In summary, the isolated strain exhibits enhanced transmission capabilities and may spread between mice via the respiratory tract, meriting greater attention and emphasis. This study will bridge the gap in China's independent P4\u2010level pathogen isolation, meet national biosafety and strategic needs, and provide certain support for LASV research.<\/jats:p>","DOI":"10.1002\/mco2.70315","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T04:08:13Z","timestamp":1754280493000},"source":"Crossref","is-referenced-by-count":2,"title":["The Biological Characteristics and Mouse Model of Lassa Virus From the First Imported Case in China"],"prefix":"10.1002","volume":"6","author":[{"given":"Yanan","family":"Zhou","sequence":"first","affiliation":[{"name":"National Kunming High\u2010Level Biosafety Primate Research Center\uff0cState Key Laboratory of Respiratory Health and Multimorbidity Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College  Kunming 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