{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T13:38:05Z","timestamp":1783690685820,"version":"3.55.0"},"reference-count":53,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,8,24]],"date-time":"2025-08-24T00:00:00Z","timestamp":1755993600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82170034"],"award-info":[{"award-number":["82170034"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81970013"],"award-info":[{"award-number":["81970013"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100013262","name":"State Key Laboratory of Respiratory Disease","doi-asserted-by":"publisher","award":["SKLRD\u2010Z\u2010202202"],"award-info":[{"award-number":["SKLRD\u2010Z\u2010202202"]}],"id":[{"id":"10.13039\/100013262","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Postinfectious subacute cough (PISC) and postinfectious chronic cough (PICC) are triggered by respiratory infections, which induce adaptive immunity. The expression of T\u2010lymphocyte subsets and cytokine signatures remains elusive in these patients. Here, we recruited 40 healthy controls, 64 PICC patients, 65 PISC patients, and 20 recovered individuals with postinfectious subacute cough (R\u2010PISC). As cough and airway inflammation resolved in R\u2010PISC subjects, sputum lymphocytes dropped substantially. Both PICC and PISC patients had an increase in blood activated interferon\u2010\u03b3 (IFN\u2010\u03b3)\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010lymphocytes, which were decreased in R\u2010PISC subjects. Elevated cough sensitivity, higher proportions of activated IFN\u2010\u03b3\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010lymphocytes, and CD8\n                    <jats:sup>+<\/jats:sup>\n                    \/CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010lymphocyte ratios, as well as elevated concentrations of uric acid, IFN\u2010\u03b3, tumor necrosis factor\u2010\u03b1 (TNF\u2010\u03b1), IFN\u2010\u03b1, IFN\u2010\u03b2, and interleukin\u201010 in sputa, were observed in PICC and PISC patients but normalized in R\u2010PISC subjects. Correlation analyses and logistic regression models identified activated IFN\u2010\u03b3\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010lymphocytes and these cytokines in sputa as biomarkers for predicting cough risk. PICC patients exhibited greater cough severity, elevated activated IFN\u2010\u03b3\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010lymphocytes, and TNF\u2010\u03b1 concentrations in sputa compared to PISC patients. Overall, postinfectious cough patients exhibit airway inflammatory signatures characterized by activated IFN\u2010\u03b3\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010lymphocytes and elevated levels of IFN\u2010\u03b3, TNF\u2010\u03b1, IFN\u2010\u03b1, IFN\u2010\u03b2, and interleukin\u201010, which are valuable for effective treatment options.\n                  <\/jats:p>","DOI":"10.1002\/mco2.70340","type":"journal-article","created":{"date-parts":[[2025,8,25]],"date-time":"2025-08-25T05:17:47Z","timestamp":1756099067000},"source":"Crossref","is-referenced-by-count":2,"title":["Activated Interferon\u2010\u03b3\u2010Positive T Lymphocytes and Cytokine Signatures in Patients With Postinfectious Cough"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2203-6384","authenticated-orcid":false,"given":"Zheng","family":"Deng","sequence":"first","affiliation":[{"name":"State Key Laboratory of Respiratory Disease Guangzhou Institute 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Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiaxing","family":"Xie","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease Guangzhou Institute of Respiratory Disease The First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haodong","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease Guangzhou Institute of Respiratory Disease The First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nanshan","family":"Zhong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Respiratory Disease Guangzhou Institute of Respiratory Disease The First Affiliated Hospital of Guangzhou Medical University  Guangzhou China"},{"name":"Guangzhou 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