{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,19]],"date-time":"2026-09-19T00:49:35Z","timestamp":1789778975255,"version":"4.0.1"},"reference-count":45,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,9,14]],"date-time":"2025-09-14T00:00:00Z","timestamp":1757808000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82470673"],"award-info":[{"award-number":["82470673"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100678"],"award-info":[{"award-number":["82100678"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003399","name":"Science and Technology Commission of Shanghai Municipality","doi-asserted-by":"publisher","award":["23ZR1440800"],"award-info":[{"award-number":["23ZR1440800"]}],"id":[{"id":"10.13039\/501100003399","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Effective early prediction of acute pancreatitis (AP) severity remains an unmet clinical need due to limited molecular characterization of systemic immune responses. We performed integrated single\u2010cell RNA sequencing with T\u2010 and B\u2010cell receptor profiling on peripheral blood mononuclear cells from AP patients (\n                    <jats:italic>n<\/jats:italic>\n                    = 7) at days 1, 3, and 7 after admission. Immune landscape analysis revealed marked inter\u2010patient heterogeneity, with a distinct expansion of MZB1\u2010expressing plasma cells that were strongly associated with complicated AP and recovery. Functional validation in an independent cohort (\n                    <jats:italic>n<\/jats:italic>\n                    = 14) confirmed disease\u2010associated plasma cell markers, alongside altered serum immunoglobulin and cytokine profiles (\n                    <jats:italic>n<\/jats:italic>\n                    = 32). From these findings, we established a nine\u2010gene B\u2010cell\u2010derived transcriptomic signature (\n                    <jats:italic>S100A8<\/jats:italic>\n                    ,\n                    <jats:italic>DUSP1<\/jats:italic>\n                    ,\n                    <jats:italic>JUN<\/jats:italic>\n                    ,\n                    <jats:italic>HBA2<\/jats:italic>\n                    ,\n                    <jats:italic>FOS<\/jats:italic>\n                    ,\n                    <jats:italic>CYBA<\/jats:italic>\n                    ,\n                    <jats:italic>JUNB<\/jats:italic>\n                    ,\n                    <jats:italic>S100A9<\/jats:italic>\n                    , and\n                    <jats:italic>WDR83OS<\/jats:italic>\n                    ) predictive of AP severity. This model demonstrated high discriminative performance in internal validation (\n                    <jats:italic>n<\/jats:italic>\n                    = 114; AUROC &gt; 0.95, superior to standard clinical scoring systems), and sustained accuracy in external validation cohorts of AP (\n                    <jats:italic>n<\/jats:italic>\n                    = 87) and AP combined with non\u2010AP sepsis (\n                    <jats:italic>n<\/jats:italic>\n                    = 174) for predicting persistent organ failure. Our study identifies a mechanistic and predictive role for MZB1\u207a plasma cells in AP pathogenesis, offering a novel immune\u2010based stratification strategy with potential for precision clinical management.\n                  <\/jats:p>","DOI":"10.1002\/mco2.70350","type":"journal-article","created":{"date-parts":[[2025,9,15]],"date-time":"2025-09-15T06:45:42Z","timestamp":1757918742000},"source":"Crossref","is-referenced-by-count":6,"title":["Single\u2010Cell Transcriptomic Atlas of Peripheral Blood Reveals B\u2010Cell\u2010Driven Signature Predictive of Acute Pancreatitis Severity"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5266-383X","authenticated-orcid":false,"given":"Rongli","family":"Xie","sequence":"first","affiliation":[{"name":"Department of General Surgery RuiJin Hospital Lu Wan Branch Shanghai Jiao Tong University School of Medicine  Shanghai 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