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In the context of HIV infection, we determined the phenotype and location of plasmacytoid and CD141+ myeloid DCs (pDCs and mDCs) in lymph nodes of people living with HIV (PLWH). We found an interaction between pDCs and CD141+ mDCs with CD8+ T cells, being associated with participants\u2019 viral levels in blood and tissue. Moreover, we demonstrated a higher and more polyfunctional superantigen\u2010 and HIV\u2010specific CD8+ T cell response after the coculture with Toll\u2010like receptor (TLR)\u2010primed pDCs and CD141+ mDCs. Last, we showed the potential of programmed cell death\u20101 (PD\u20101) blocking using pembrolizumab to further increase antigen\u2010specific CD8+ T cell response along with TLR agonists. Therefore, these results showed a cooperation between pDCs, CD141+ mDCs and CD8+ T cells in lymph nodes of PLWH, which is associated with higher HIV control, highlighting the importance of DC subsets crosstalk to achieve a more potent anti\u2010HIV response and support the use of DC\u2010based immunotherapies for HIV control.<\/jats:p>","DOI":"10.1002\/mco2.70354","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T08:43:29Z","timestamp":1757666609000},"source":"Crossref","is-referenced-by-count":0,"title":["Plasmacytoid and CD141+ Myeloid Dendritic Cells Cooperation with CD8+ T Cells in Lymph Nodes is Associated with HIV Control"],"prefix":"10.1002","volume":"6","author":[{"given":"Joana","family":"Vitall\u00e9","sequence":"first","affiliation":[{"name":"Institute of Biomedicine of Seville, IBiS\/Virgen Del Roc\u00edo University Hospital\/CSIC\/University of Seville Clinical Unit of Infectious Diseases, Microbiology and Parasitology  Seville 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