{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T07:08:03Z","timestamp":1783840083555,"version":"3.55.0"},"reference-count":36,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T00:00:00Z","timestamp":1763596800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81930063"],"award-info":[{"award-number":["81930063"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82241075"],"award-info":[{"award-number":["82241075"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32200718"],"award-info":[{"award-number":["32200718"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC0871500"],"award-info":[{"award-number":["2023YFC0871500"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    In the global response to the current mpox epidemic, understanding immune memory to the vaccinia virus and cross\u2010immunity to the mpox virus (MPXV) among people living with HIV (PLWH) is critical. Blood samples were collected from PLWH born between 1949 and 2002 without MPXV infection, as well as from sex\u2010 and age\u2010matched healthy donors (HD). Note that 62% and 56% of vaccinated PLWH born before 1980 had antibodies against the vaccinia virus Tiantan (VTT) strain and MPXV, respectively, though these seropositivity rates were lower than in HD (84%\u00a0vs. 80%). Neutralizing antibodies were detected in 9% of PLWH, compared to 32% in HD. Notably, in PLWH with CD4 T\u2010cell counts below 500 cells\/mm\n                    <jats:sup>3<\/jats:sup>\n                    , VTT\u2010IgG and MPXV\u2010IgG titers, as well as VTT\u2010specific memory B cells, were significantly reduced. In PLWH with CD4 T\u2010cell counts below 350 cells\/mm\n                    <jats:sup>3<\/jats:sup>\n                    , CD4\n                    <jats:sup>+<\/jats:sup>\n                    memory T\u2010cell responses were diminished, particularly in IFN\u2010\u03b3 and TNF\u2010\u03b1 responses. In contrast, CD8\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell responses to MPXV were comparable in PLWH regardless of CD4 T\u2010cell counts. These findings highlight the diminished humoral and CD4\n                    <jats:sup>+<\/jats:sup>\n                    T\u2010cell responses in PLWH, particularly in those with lower CD4 T\u2010cell counts, and underscore the necessity for targeted vaccination strategies in this population.\n                  <\/jats:p>","DOI":"10.1002\/mco2.70399","type":"journal-article","created":{"date-parts":[[2025,11,21]],"date-time":"2025-11-21T07:26:44Z","timestamp":1763710004000},"source":"Crossref","is-referenced-by-count":1,"title":["Impaired Cellular Immunity and Cross\u2010Reactive Humoral Responses to Mpox Virus in HIV\u2010Infected Individuals Vaccinated with Vaccinia Virus Tiantan Strain"],"prefix":"10.1002","volume":"6","author":[{"given":"Qiao","family":"Zhang","sequence":"first","affiliation":[{"name":"NHC Key Laboratory of Systems Biology of Pathogens and Christophe M\u00e9rieux Laboratory, National Institute of Pathogen Biology, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Song","sequence":"additional","affiliation":[{"name":"Beijing Ditan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Huang","sequence":"additional","affiliation":[{"name":"Center For AIDS Research Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meiyu","family":"Fang","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Systems Biology of Pathogens and Christophe M\u00e9rieux Laboratory, National Institute of Pathogen Biology, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyou","family":"Chen","sequence":"additional","affiliation":[{"name":"Beijing Ditan Hospital Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Danyang","family":"Li","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Systems Biology of Pathogens and Christophe M\u00e9rieux Laboratory, National Institute of Pathogen Biology, Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanan","family":"Li","sequence":"additional","affiliation":[{"name":"NHC Key Laboratory of Systems Biology of Pathogens and Christophe M\u00e9rieux Laboratory, National Institute of Pathogen Biology, Chinese Academy of Medical Sciences &amp; 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