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Thus, devising therapeutic strategies that can mitigate hematopoietic toxicity caused by IR would benefit acute radiation syndrome (ARS) victims and patients receiving radiotherapy. Herein, we describe the preparation of an injectable hydrogel formulation based on Arg\u2010Gly\u2010Asp\u2010alginate (RGD\u2010Alg) and Laponite using a simple mixing method that ensured a slow and sustained release of interleukin\u201012 (IL\u201012) (RGD\u2010Alg\/Laponite@IL\u201012). The local administration of RGD\u2010Alg\/Laponite@IL\u201012 increased survival rates and promoted the hematopoietic recovery of mice who had received sublethal\u2010dose irradiation. Local intra\u2010bone marrow (intra\u2010BM) injection of RGD\u2010Alg\/Laponite@IL\u201012 hydrogel effectively stimulated IL12 receptor\u2010phosphoinositide 3\u2010kinase\/protein kinase B (IL\u201012R\u2010PI3K\/AKT) signaling axis, which promoted proliferation and hematopoietic growth factors secretion of BM mesenchymal stem\/stromal cells. This signaling axis facilitates the repair of the hematopoietic microenvironment and plays a pivotal role in hematopoietic reconstitution. In conclusion, we describe a biomaterial\u2010sustained release of IL\u201012 for the treatment of irradiated hematopoietic injury and provide a new therapeutic strategy for hematopoietic ARS.<\/jats:p>","DOI":"10.1002\/mco2.704","type":"journal-article","created":{"date-parts":[[2024,9,12]],"date-time":"2024-09-12T13:35:19Z","timestamp":1726148119000},"source":"Crossref","is-referenced-by-count":1,"title":["Interleukin\u201012 sustained release system promotes hematopoietic recovery after radiation injury"],"prefix":"10.1002","volume":"5","author":[{"given":"Chuanchuan","family":"Lin","sequence":"first","affiliation":[{"name":"Laboratory of Radiation Biology, Department of Blood Transfusion, Laboratory Medicine Center The Second Affiliated Hospital, Army Medical University  Chongqing China"},{"name":"Hematopoietic Acute Radiation Syndrome Medical and Pharmaceutical Basic Research Innovation Center Ministry of Education of the People's Republic of China  Chongqing 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