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Contemporary AMI research has evolved from an initial focus on local myocardial injury to a broader perspective encompassing the entire disease course, including tissue damage, remodeling, and multi\u2010organ interactions. This review systematically delineates the key molecular mechanisms underlying AMI and subsequent ventricular remodeling, while also exploring the complex interplay between the heart and other organs such as the gut, brain, kidney, and liver. From a clinical standpoint, we summarize the historical evolution of AMI diagnostic criteria and management strategies, highlighting current classification systems, novel diagnostic technologies, and the integration of artificial intelligence tools. Furthermore, we present recent evidence\u2010based advances in established therapeutic approaches, along with emerging strategies ranging from cellular to genetic interventions. Future directions aim to integrate mechanistic insights with interdisciplinary clinical strategies to establish a systematic and precision\u2010based framework for AMI prevention and management.<\/jats:p>","DOI":"10.1002\/mco2.70418","type":"journal-article","created":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T07:28:39Z","timestamp":1759822119000},"source":"Crossref","is-referenced-by-count":42,"title":["Acute Myocardial Infarction: Molecular Pathogenesis, Diagnosis, and Clinical Management"],"prefix":"10.1002","volume":"6","author":[{"given":"Mengmeng","family":"Zhu","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Cardiovascular Diseases of Traditional Chinese Medicine Xiyuan Hospital of China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiwen","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases Experimental Research Center China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Xu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Cardiovascular Diseases of Traditional Chinese Medicine Xiyuan Hospital of China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Traditional Chinese Medicine Peking Union Medical College Hospital Chinese Academy of Medical Sciences and Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanfei","family":"Liu","sequence":"additional","affiliation":[{"name":"The Second Department of Geriatrics Xiyuan Hospital China Academy of Chinese Medical Sciences  Beijing China"},{"name":"Key Laboratory of Disease and Syndrome Integration Prevention and Treatment of Vascular Aging Xiyuan Hospital of China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0084-863X","authenticated-orcid":false,"given":"Yue","family":"Liu","sequence":"additional","affiliation":[{"name":"National Clinical Research Center for Cardiovascular Diseases of Traditional Chinese Medicine Xiyuan Hospital of China Academy of Chinese Medical Sciences  Beijing China"},{"name":"Key Laboratory of Disease and Syndrome Integration Prevention and Treatment of Vascular Aging Xiyuan Hospital of China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,10,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-023-03231-w"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwad214"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehac667"},{"issue":"8","key":"e_1_2_12_5_1","first-page":"1111","article-title":"Left Ventricular Remodeling After Myocardial Infarction: From Physiopathology to Treatment","volume":"12","author":"Leanc\u0103 S. 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