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In addition to the hypothalamic suprachiasmatic nucleus, the circadian system is organized in multiple peripheral tissues, such as the brain, heart, bone, liver, and lung. Emerging evidence suggests that disruptions in these rhythms, which are regulated by a network of clock genes, play pivotal roles in human health. A deeper understanding of the interplay between circadian rhythms and tissue homeostasis holds significant potential for the development of targeted therapies aimed at improving human health. This review explores the link between circadian rhythms and tissue homeostasis, delving into their biological functions, including influences on metabolic homeostasis, neuroendocrine signaling, immune and oxidative stress responses, tissue repair, and autophagy activity. It also summarizes the connections between circadian disruptions and circadian disruption\u2010related diseases, including degenerative diseases, cardiometabolic disorders, and cancers. Furthermore, this review offers valuable perspectives on the treatment of circadian disruption\u2010related diseases. By revealing the regulatory influence of circadian rhythms on human health and disease, this work aims to inspire the development of novel strategies for the prevention, diagnosis, and treatment of circadian disruption\u2010related diseases.<\/jats:p>","DOI":"10.1002\/mco2.70435","type":"journal-article","created":{"date-parts":[[2025,10,23]],"date-time":"2025-10-23T06:57:58Z","timestamp":1761202678000},"source":"Crossref","is-referenced-by-count":22,"title":["Circadian Rhythm: Biological Functions, Diseases, and Therapeutic Targets"],"prefix":"10.1002","volume":"6","author":[{"given":"Kangkang","family":"Zha","sequence":"first","affiliation":[{"name":"Department of Orthopaedics Union Hospital Tongji Medical College Huazhong University of Science and Technology  Wuhan China"},{"name":"Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration  Wuhan 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