{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T23:24:38Z","timestamp":1788305078647,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,14]],"date-time":"2025-11-14T00:00:00Z","timestamp":1763078400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32441090"],"award-info":[{"award-number":["32441090"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2025,12]]},"abstract":"ABSTRACT<\/jats:title>\n \n Lupus nephritis (LN) is one of the most severe manifestation of systemic lupus erythematosus (SLE). However, reliable tools for predicting LN risk remain limited. In this multicenter prospective cohort study, we developed, validated, and refined a risk stratification model for new\u2010onset LN. A total of 2441 SLE patients without baseline renal involvement were consecutively enrolled from the Chinese SLE Treatment and Research (CSTAR) registry, with 215 (8.8%) developed LN in a median follow\u2010up time of 3.5 years. A combination of clinical predictors, age < 30 years, absence of arthritis, serositis, hypocomplementemia, and positive anti\u2010double\u2010stranded DNA antibodies identified a clinical high\u2010risk group (\n n<\/jats:italic>\n = 537, 22.0%) with a 3\u2010year LN incidence of 18.1%. The model was externally validated in 451 patients, with 50 developed LN in a median follow\u2010up time of 3.4 years. In these patients, a genetic risk score (GRS) derived from 112 SLE\u2010associated loci was found to be independently associated with LN (HR = 3.19, 95% CI, 1.83\u20135.55,\n p<\/jats:italic>\n = 4.36 \u00d7 10\n \u22125<\/jats:sup>\n ). Among clinically low\u2010risk individuals, those in the highest GRS quartiles (81\/451, 18.0%) showed elevated 3\u2010year LN incidence (15.5%\u00a0vs. 1.4%). New\u2010onset LN may be predicted using a combination of clinical risk factors, and integrating GRS further improves risk stratification, enabling early identification of high\u2010risk patients.\n <\/jats:p>","DOI":"10.1002\/mco2.70453","type":"journal-article","created":{"date-parts":[[2025,11,15]],"date-time":"2025-11-15T06:45:08Z","timestamp":1763189108000},"source":"Crossref","is-referenced-by-count":2,"title":["Applying Genetic Risk Score to Improve Risk Assessment of New\u2010Onset Lupus Nephritis in Systemic Lupus Erythematosus: A Large\u2010Scale Prospective Cohort Study"],"prefix":"10.1002","volume":"6","author":[{"given":"Yufang","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Rheumatology and Clinical Immunology Peking Union Medical College Hospital Chinese Academy of Medical Sciences Beijing China"},{"name":"National Clinical Research Center for Dermatologic and Immunologic Diseases (NCRC\u2010DID) Ministry of Science & Technology Beijing 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