{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T14:01:12Z","timestamp":1785420072147,"version":"3.56.0"},"reference-count":48,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T00:00:00Z","timestamp":1762819200000},"content-version":"vor","delay-in-days":10,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82341230"],"award-info":[{"award-number":["82341230"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20240003"],"award-info":[{"award-number":["BK20240003"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Multiple myeloma (MM), as an incurable hematologic malignancy, is driven by chromosomal translocations. Recent research suggests that targeting phase separation may offer a new therapeutic vulnerability for MM. The transcription factor c\u2010Maf is implicated in MM\u2010associated translocations and undergoes liquid\u2013liquid phase separation (LLPS). Although c\u2010Maf is historically classified as \u201cundruggable\u201d for its transcription factor nature, we propose a new therapeutic strategy targeting its phase separation mechanism. Comprehensive in vitro and in vivo experiments indicated that elevated c\u2010Maf promoted MM progression through LLPS. Mechanistically, the alanine\u2010rich intrinsically disordered regions (IDRs) in c\u2010Maf drive hydrophobic interactions, enabling phase separation. These IDRs recruit RNA Polymerase II (RNA Pol II) through similar interactions, forming oncogenic condensates that activate the Mtbp\/c\u2010Myc axis. Notably, we discovered benzoyl benzoic acid (BBA) as a candidate compound targeting the inter\u2010IDR interaction domain of c\u2010Maf. BBA binding impedes c\u2010Maf's LLPS capacity, consequently blocking RNA Pol II recruitment and Mtbp transcriptional activation. This mechanistic interference successfully inhibited c\u2010Myc\u2010driven MM progression in experimental models. Our study demonstrates that c\u2010Maf\u2010driven LLPS activates the c\u2010Maf\/RNA Pol II\/Mtbp\/c\u2010Myc axis, highlighting phase separation targeting as a promising therapeutic strategy for translocation\u2010associated MM patients.<\/jats:p>","DOI":"10.1002\/mco2.70464","type":"journal-article","created":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T07:18:17Z","timestamp":1762931897000},"source":"Crossref","is-referenced-by-count":1,"title":["Targeting the Liquid\u2013Liquid Separation Region of c\u2010Maf for Treating Chromosomal Translocations in Multiple Myeloma"],"prefix":"10.1002","volume":"6","author":[{"given":"Ze","family":"Wang","sequence":"first","affiliation":[{"name":"Nanjing Hospital of Chinese Medicine Affiliated With Nanjing University of Chinese Medicine  Nanjing China"},{"name":"School of Medicine Nanjing University of Chinese Medicine  Nanjing 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