{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T09:53:02Z","timestamp":1787997182648,"version":"build-2784847793"},"reference-count":78,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T00:00:00Z","timestamp":1762732800000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Stress granules (SGs) are cytoplasmic condensates that regulate mRNA translation and signaling in response to stress. Although SGs have been widely studied in antiviral responses, their function in bacterial infections is not well understood. Here, we demonstrate that SGs promote\n                    <jats:italic>Mycobacterium tuberculosis<\/jats:italic>\n                    (Mtb) pathogenesis by suppressing mitochondrial metabolism and innate immunity. Quantitative proteomics revealed that Mtb\u2010induced SGs sequester mTORC1 and suppress cap\u2010dependent mRNA translation. This leads to decreased expression of proteins necessary for mitochondrial respiration and immune activation in bone marrow\u2010derived macrophages (BMDMs). Disrupting SG assembly restored mTORC1 signaling, enhanced oxidative phosphorylation, and increased the production of antimicrobial mediators, such as reactive oxygen species, nitric oxide, and proinflammatory cytokines. This restricted intracellular Mtb growth in vitro and in vivo. Mechanistically, intracellular ATP depletion triggered by Mtb phagocytosis was sufficient to drive SG formation, linking energy stress to translational repression. Furthermore, SGs captured Ndufa12, a complex I subunit, thereby impairing mitochondrial electron transport and ATP production. These findings identify SGs as key regulators that couple translational arrest to metabolic and immune suppression, enabling Mtb persistence. Targeting SG formation or function could be a host\u2010directed strategy to restore mitochondrial activity and strengthen immune responses against Mtb infection.\n                  <\/jats:p>","DOI":"10.1002\/mco2.70479","type":"journal-article","created":{"date-parts":[[2025,11,10]],"date-time":"2025-11-10T11:15:16Z","timestamp":1762773316000},"source":"Crossref","is-referenced-by-count":1,"title":["Host Translational Control by Stress Granules Promotes\n                    <i>Mycobacterium tuberculosis<\/i>\n                    Pathogenesis"],"prefix":"10.1002","volume":"6","author":[{"given":"Jaewhan","family":"Kim","sequence":"first","affiliation":[{"name":"Department of Medical Science, College of Medicine Chungnam National University  Daejeon Republic of Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang\u2010Hun","family":"Son","sequence":"additional","affiliation":[{"name":"Department of Medical Science, College of Medicine Chungnam National University 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