{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T02:46:23Z","timestamp":1790477183060,"version":"4.1.0"},"reference-count":52,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Triple\u2010negative breast cancer (TNBC) is an aggressive subtype with limited therapeutic options and poor prognosis. Cluster of differentiation 36 (CD36), a fatty acid transporter, plays controversial roles in tumor progression. Here, we report a tumor\u2010suppressive function of CD36 in TNBC. Analysis of The Cancer Genome Atlas and Gene Expression Omnibus databases, along with validation in clinical samples, revealed that CD36 expression was significantly downregulated in TNBC tissues, and its low expression correlated with advanced disease stage and poorer patient prognosis. Functional assays demonstrated that CD36 knockout promoted, whereas its overexpression inhibited, the proliferation, migration, and invasion of TNBC cells. Integrated transcriptomic and proteomic analyses linked CD36 to ferroptosis, an iron\u2010dependent form of regulated cell death. Mechanistically, CD36 enhanced the transcriptional activity of peroxisome proliferator\u2010activated receptor gamma (PPAR\u03b3), which in turn upregulated the expression of caveolin\u20101 (CAV1). This CD36\/PPAR\u03b3\/CAV1 axis increased intracellular lipid peroxidation, thereby promoting ferroptosis. In vivo, a CD36 agonist suppressed, while a ferroptosis activator inhibited the metastasis of CD36\u2010knockdown TNBC cells. Our findings identify CD36 as a novel tumor suppressor in TNBC that acts by promoting ferroptosis, highlighting its potential as both a prognostic biomarker and a therapeutic target.<\/jats:p>","DOI":"10.1002\/mco2.70493","type":"journal-article","created":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T06:54:06Z","timestamp":1763535246000},"source":"Crossref","is-referenced-by-count":6,"title":["CD36 Inhibits Triple\u2010Negative Breast Cancer Progression by Transcriptionally Upregulating Caveolin\u20101 and Promoting Lipid\u2010Reactive Oxygen Species\u2010Related Ferroptosis"],"prefix":"10.1002","volume":"6","author":[{"given":"Xiujuan","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Breast and Thyroid Surgery\/Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis and Treatment of Breast Cancer Southwest Hospital, Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery\/Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis and Treatment of Breast Cancer Southwest Hospital, Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaihui","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery\/Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis and Treatment of Breast Cancer Southwest Hospital, Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery\/Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis and Treatment of Breast Cancer Southwest Hospital, Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuanni","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery\/Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis and Treatment of Breast Cancer Southwest Hospital, Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenting","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery\/Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis and Treatment of Breast Cancer Southwest Hospital, Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuqin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery\/Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis and Treatment of Breast Cancer Southwest Hospital, Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Xia","sequence":"additional","affiliation":[{"name":"Key Laboratory of Molecular Biology For Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University  Chongqing China"},{"name":"Western(Chongqing) Collaborative Innovation Center for Intelligent Diagnostics and Digital Medicine Chongqing National Biomedicine Industry Park  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery\/Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis and Treatment of Breast Cancer Southwest Hospital, Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Breast and Thyroid Surgery\/Key Laboratory of Chongqing Health Commission for Minimally Invasive and Precise Diagnosis and Treatment of Breast Cancer Southwest Hospital, Army Medical University  Chongqing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,11,18]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21820"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-3045"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22618"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-06-1109"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.06.5664"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00011.2023"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.272re3"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-017-0093-z"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-019-1049-7"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature20791"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/stem.1716"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.21570"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-1166"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201800985R"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.21046"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-11662-3"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41389-018-0107-x"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.11.008"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-010-1085-7"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-12-0107"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2003.10.021"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.03.042"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.12.010"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.2239"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-023-01606-1"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.28251"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2017.07.036"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.44705"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00216-5"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2006828117"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-0149-3"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2021.101928"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-017-0053-8"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-022-00459-0"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2022.09.021"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2017.126"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-023-00529-z"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djac126"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.03.061"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2015.6317"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-03813-6"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2019.02.012"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20150658"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2015.06.011"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-20-3944"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.788417"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2023.189002"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19051529"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.77.061307.091829"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.21.22.7558-7568.2001"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm3312"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-023-01805-y"}],"container-title":["MedComm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.70493","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mco2.70493","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.70493","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T06:39:42Z","timestamp":1783838382000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mco2.70493"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11,18]]},"references-count":52,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1002\/mco2.70493"],"URL":"https:\/\/doi.org\/10.1002\/mco2.70493","archive":["Portico"],"relation":{},"ISSN":["2688-2663","2688-2663"],"issn-type":[{"value":"2688-2663","type":"print"},{"value":"2688-2663","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,11,18]]},"article-number":"e70493"}}