{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T03:47:56Z","timestamp":1791863276053,"version":"4.3.4"},"reference-count":349,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T00:00:00Z","timestamp":1764720000000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Cancer is more than just a collection of tumor cells. The complex tumor system, including the tumor immune microenvironment (TIME), is continually changing. Tumor cells are in constant communication with all stromal elements (e.g., fibroblasts, endothelial cells, and extracellular matrix) and immune effector cells (e.g., T cells, B cells, natural killer cells, dendritic cells, macrophages, and myeloid\u2010derived suppressor cells). Together, these intricate interactions among cell and molecular signaling pathways collectively drive tumor growth, tumor invasion, and metastasis and significantly affect the efficacy of cancer treatments. Recent investigations, from a tumor\u2010centric research paradigm to a complete evaluation of the local tumor microenvironment, have revealed the importance of the TIME. Although reviews in these fields typically focus on cellular\/molecular breakdowns of the TIME and evasion of the immune system, a systematic study of its dynamic evolution is lacking. This review comprehensively discusses the major regulators and networks involved in the dynamic evolution of the TIME, the spatiotemporal dynamics of TIME components, metabolic reprogramming as an engine of TIME evolution, the targeting of metabolic regulators, and niches for TIME modulation, clinical and translational challenges, and future prospects. This information could help researchers explore the TIME and generate new therapeutic strategies.<\/jats:p>","DOI":"10.1002\/mco2.70496","type":"journal-article","created":{"date-parts":[[2025,12,3]],"date-time":"2025-12-03T17:06:15Z","timestamp":1764781575000},"source":"Crossref","is-referenced-by-count":13,"title":["Dynamic Evolution of the Tumor Immune Microenvironment in Malignant Tumors and Emerging Therapeutic Paradigms"],"prefix":"10.1002","volume":"6","author":[{"given":"Ying","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery The Second Affiliated Hospital Air Force Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changjian","family":"Shao","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The Second Affiliated Hospital Air Force Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongtao","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The Second Affiliated Hospital Air Force Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaoyang","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The Second Affiliated Hospital Air Force Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaopeng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The Second Affiliated Hospital Air Force Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The Second Affiliated Hospital Air Force Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiawei","family":"Xiu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The Second Affiliated Hospital Air Force Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The Second Affiliated Hospital Air Force Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuejiao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The Second Affiliated Hospital Air Force Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The Second Affiliated Hospital Air Force Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan","family":"Gao","sequence":"additional","affiliation":[{"name":"A State Key Laboratory of Cancer Biology Biotechnology Center School of Pharmacy Air Force Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolong","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The Second Affiliated Hospital Air Force Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,3]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-025-02442-3"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2025.09.004"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.70056"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaf983"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2025.189461"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2025.218069"},{"key":"e_1_2_14_8_1","article-title":"ESMO\u2010ESTRO Consensus Statements on the Safety of Combining Radiotherapy With Immune Checkpoint Inhibitors, VEGF(R) Inhibitors, or Multitargeted Tyrosine Kinase Inhibitors","volume":"208","author":"Aken E. 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