{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:58:54Z","timestamp":1791896334888,"version":"4.3.4"},"reference-count":52,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2025,12,12]],"date-time":"2025-12-12T00:00:00Z","timestamp":1765497600000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,12,1]],"date-time":"2025-12-01T00:00:00Z","timestamp":1764547200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Early T\u2010cell precursor acute lymphoblastic leukemia (ETP\u2010ALL) is an aggressive subtype of T\u2010ALL. Once refractory or relapsed, it is associated with a poor prognosis, with a complete remission (CR) rate of 36%\u201346% following re\u2010induction therapy. Previously, we reported a synergistic effect of venetoclax (VEN) and homoharringtonine (HHT) in ETP\u2010ALL, which potentially elicits notable clinical responses. Herein, we investigated the efficacy and safety of the V\u2010HAG regimen (VEN, HHT, cytarabine, and granulocyte colony\u2010stimulating factor [G\u2010CSF]) in patients with refractory\/relapsed ETP\u2010ALL through a prospective, multicenter, single\u2010arm, open\u2010label, phase 2 clinical trial. A total of 18 patients were enrolled, and 100% of these patients achieved CR or CR with incomplete hematological recovery (CRi) after 1 cycle of the V\u2010HAG regimen as re\u2010induction therapy. As a follow\u2010up, both the relapse rate and mortality rate were 33.3%. The 1\u2010year overall survival and relapse\u2010free survival were 76.7% (95% confidence interval [CI]: 53.2%\u2010100.0%) and 55.7% (95% CI: 28.8%\u201382.6%), respectively. The most common grade 3\u20134 adverse events were neutropenia (100%), anemia (88.9%), and thrombocytopenia (100%). Notably, the VEN\u2010 and HHT\u2010based therapy, V\u2010HAG regimen, exhibits an extremely high efficacy in the treatment of patients with refractory\/relapsed ETP\u2010ALL with good tolerance, and it provides a promising therapeutic strategy for improving their outcomes.<\/jats:p>","DOI":"10.1002\/mco2.70549","type":"journal-article","created":{"date-parts":[[2025,12,13]],"date-time":"2025-12-13T06:41:52Z","timestamp":1765608112000},"source":"Crossref","is-referenced-by-count":2,"title":["Venetoclax and Homoharringtonine\u2010Based Therapy Exhibited a Striking Response in Refractory\/Relapsed Early T\u2010Cell Precursor Acute Lymphoblastic Leukemia"],"prefix":"10.1002","volume":"6","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7543-8352","authenticated-orcid":false,"given":"Xiang","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital Zhejiang University School of Medicine  Hangzhou Zhejiang PR 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Shanghai PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated People's Hospital of Ningbo University  Ningbo Zhejiang PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenfang","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Guangxi Medical University  Nanning Guangxi PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuzhen","family":"Tong","sequence":"additional","affiliation":[{"name":"Department of Hematology First Affiliated Hospital of Sun Yat Sen University  Guangzhou Guangdong PR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aiping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology Baoshan Hospital Shanghai University of Traditional Chinese Medicine  Shanghai Shanghai 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