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We investigated whether adherence to several dietary patterns relates to gut microbial signatures and whether these profiles are associated with depressive symptoms in an elderly Mediterranean cohort. In 644 participants, 16S ribosomal RNA gene sequencing and dietary intake from a food\u2010frequency questionnaire were obtained at baseline and 1\u2010year follow\u2010up. Adherence scores were computed for the Mediterranean diet adherence score (MEDAS), energy\u2010reduced MEDAS (erMEDAS), Dietary Approaches to Stop Hypertension (DASH), Healthy Plant\u2010Based Diet Index (HPDI), Unhealthy Plant\u2010Based Diet Index (UPDI), and Western Diet Score (WESTDIET). Healthy patterns (erMEDAS, MEDAS, DASH, HPDI) were associated with 22, 28, 24, and 16 genera, of which 82%, 75%, 79%, and 88% showed a protective profile (more abundant with lower, or less abundant with higher, depressive symptoms). UPDI and WESTDIET were associated with 20 and 27 genera, but only 25% and 26% were protective. Mediation analyses indicated that gut microbiota mediated the associations of MEDAS (ACME = \u20130.066,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.006) and erMEDAS (ACME = \u20130.029,\n                    <jats:italic>p<\/jats:italic>\n                    = 0.011) with depressive symptoms. This study is among the first to test whether diet shapes a microbiota signature that mediates the diet\u2013depression relationship, adding mechanistic insight into diet\u2013mental health research.\n                  <\/jats:p>","DOI":"10.1002\/mco2.70562","type":"journal-article","created":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T07:19:53Z","timestamp":1768979993000},"source":"Crossref","is-referenced-by-count":3,"title":["The Gut Microbiota as a Mediator in the Relationship Between Dietary Patterns and Depression"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5250-1048","authenticated-orcid":false,"given":"Adri\u00e1n","family":"Hern\u00e1ndez\u2010Cacho","sequence":"first","affiliation":[{"name":"Universitat Rovira i Virgili Departament De Bioqu\u00edmica i Biotecnologia Alimentaci\u00f3, Nutrici\u00f3, Desenvolupament i Salut Mental ANUT\u2010DSM  Reus Spain"},{"name":"Institut D'investigaci\u00f3 Sanit\u00e0ria Pere Virgili 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