{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T14:53:08Z","timestamp":1769266388546,"version":"3.49.0"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T00:00:00Z","timestamp":1768262400000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3403800"],"award-info":[{"award-number":["2023YFC3403800"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC3403804"],"award-info":[{"award-number":["2023YFC3403804"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82141127"],"award-info":[{"award-number":["82141127"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Hepatocellular carcinoma (HCC) was characterized by a highly complex genome, with structural variations (SVs) playing a significant role in its development. In this study, we employed Oxford Nanopore Technology long\u2010read sequencing in paired tumor and adjacent normal liver tissues from 74 Chinese HCC patients to thoroughly characterize the landscape of somatic SVs. Our analysis revealed that somatic SVs were more prevalent in hepatitis B virus (HBV)\u2010related HCC, with chromosome 1 emerging as a major hotspot, and several members of the chromosome 1 open reading frame (C1orf) family genes expression level exhibited significant age\u2010related difference. Notably, HBV\u2010related HCC cases exhibited a higher frequency of deletions, particularly among younger ones (\u2264 35 years old). In addition, we observed an increased burden of HBV integration events in younger ones. Remarkably, the divergent\u2010paired related homeobox (\n DPRX<\/jats:italic>\n ) loci was identified as a novel gene for HBV integration in younger patients. Together, these findings delineated the somatic SV landscape in HCC and underscored age\u2010associated HBV\u2010related genomic alterations as key pathological features of hepatocarcinogenesis.\n <\/jats:p>","DOI":"10.1002\/mco2.70570","type":"journal-article","created":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T08:37:29Z","timestamp":1768293449000},"source":"Crossref","is-referenced-by-count":0,"title":["Landscape of Somatic and Age\u2010Related Pathogenic Structural Variations in Hepatocellular Carcinoma Revealed by Long\u2010Read Sequencing"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5468-1508","authenticated-orcid":false,"given":"Zhewen","family":"Wei","sequence":"first","affiliation":[{"name":"Department of Hepatobiliary Surgery National Cancer Center\/National Clinical Research Center for Cancer\/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China"},{"name":"Key Laboratory of Gene 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