{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T21:05:46Z","timestamp":1790370346688,"version":"4.1.0"},"reference-count":46,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T00:00:00Z","timestamp":1767571200000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The clinical utility of mesenchymal stem cells (MSCs) is often limited by pulmonary entrapment and poor systemic distribution, particularly in diseases constrained by physiological barriers such as rheumatoid arthritis (RA), where joint accessibility restricts therapeutic efficacy. This study systematically compares the immunomodulatory capacity and inflammation\u2010targeting potential of human gingiva\u2010derived MSCs (GMSCs) and their extracellular vesicles (GMSC\u2010EVs) in vivo. Using an experimental RA model, we demonstrate that GMSC\u2010EVs exhibit superior tropism to inflamed joints compared to GMSCs, resulting in significantly greater amelioration of disease severity, including reduced joint swelling, bone destruction, and balanced pathogenic T\u2010cell responses. Mechanistically, we identify C\u2010C chemokine receptor type 2 (CCR2) as the critical molecular driver of this targeted homing. Genetic ablation of CCR2 via CRISPR\u2010Cas9\/sgRNA knockdown abolishes both the joint\u2010specific accumulation of GMSC\u2010EVs and their therapeutic efficacy. These findings elucidate the molecular basis for GMSC\u2010EVs tropism to arthritic lesions and establish CCR2 as a pivotal target for developing precision\u2010engineered EVs therapies with enhanced specificity for RA treatment.<\/jats:p>","DOI":"10.1002\/mco2.70576","type":"journal-article","created":{"date-parts":[[2026,1,6]],"date-time":"2026-01-06T07:51:14Z","timestamp":1767685874000},"source":"Crossref","is-referenced-by-count":3,"title":["CCR2 Orchestrates Preferential Homing and Therapeutic Efficacy of Gingival Mesenchymal Stem Cell\u2010Derived Extracellular Vesicles in Rheumatoid Arthritis"],"prefix":"10.1002","volume":"7","author":[{"given":"Jingrong","family":"Chen","sequence":"first","affiliation":[{"name":"Division of Rheumatology Department of Medicine Songjiang Research Institute Songjiang Hospital Affiliated to Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Department of Immunology School of Cell and Gene Therapy Songjiang Research 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