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Dendritic cells (DCs) play a crucial role in linking innate and adaptive immune responses, and therefore they deeply participate in the initiation and development of SLE. Deleted in breast cancer\u20101 (DBC1) is a negative regulator of deacetylase SIRT1 (the mammalian homolog of silent information regulator 1) and involves in tissue inflammation. Roles of DBC1 in immune cells remain largely unknown, especially in DCs. We here identified that DBC1 is upregulated in activated DCs, and DBC1 deficiency weakened DC maturation while promoting B7\u2010H1 expression. DC conditional knockout of DBC1 ameliorated murine lupus pathology by decreasing autoantibodies, complement C3, plasma cells, and follicular T helper (Tfh) cells, whereas promoting regulatory T\u2010cell development. We further demonstrated that\n                    <jats:italic>\n                      Dbc1\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    DC lowered proinflammatory cytokine secretion such as IL\u20104, IL\u20106, and IL\u201012, and reduced signal transducer and activator of transcription 5 (STAT5) signal. With STAT5 overexpression, the protective effect by\n                    <jats:italic>\n                      Dbc1\n                      <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    <\/jats:italic>\n                    DC was abolished in the lupus model. Therefore, targeting the DBC1\u2010STAT5 axis in DCs diversifies the therapeutic strategies for SLE.\n                  <\/jats:p>","DOI":"10.1002\/mco2.70581","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T13:21:07Z","timestamp":1768396867000},"source":"Crossref","is-referenced-by-count":1,"title":["Regulation and Mechanism of Deleted in Breast Cancer\u20101 on Dendritic Cell Function in Systemic Lupus Erythematosus"],"prefix":"10.1002","volume":"7","author":[{"given":"Ze Xiu","family":"Xiao","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Songjiang Hospital affiliated to the Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Department of Immunology the School of Cell and Gene Therapy Songjiang Research Institute Songjiang Hospital affiliated to the Shanghai Jiao Tong University School of Medicine  Shanghai China"},{"name":"Department of Clinical Immunology The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rongzhen","family":"Liang","sequence":"additional","affiliation":[{"name":"Department of Immunology the School of Cell and Gene Therapy Songjiang Research Institute Songjiang Hospital affiliated to the Shanghai Jiao Tong University School of Medicine  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yan","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Clinical Immunology The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"},{"name":"Department of Rheumatology The Third Affiliated Hospital of Sun Yat\u2010Sen University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Changyuan","family":"Huang","sequence":"additional","affiliation":[{"name":"The First Dongguan Affiliated Hospital Guangdong Medical University  Dongguan 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