{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T15:19:36Z","timestamp":1769267976238,"version":"3.49.0"},"reference-count":70,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T00:00:00Z","timestamp":1767830400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,1]],"date-time":"2026-01-01T00:00:00Z","timestamp":1767225600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Colorectal cancer (CRC) ranks as the third leading cause of cancer\u2010related deaths worldwide, characterized by genomic heterogeneity arising from ethnic and interindividual differences. Producing region\u2010specific data to characterize ethnic\u2010specific somatic mutations is essential for advancing CRC research. Additionally, accurate somatic mutation detection requires paired tissue analyses to account for interindividual diversity. This study aims to highlight the importance of ethnic diversity in shaping CRC's genomic landscape and emphasize the necessity for region\u2010specific data to refine diagnostic and therapeutic approaches. This study emphasizes the need for region\u2010specific data by analyzing an unprecedented 197 paired samples from the Korean CRC cohort through whole\u2010genome sequencing. We identified 78 potential driver genes. Notably,\n                    <jats:italic>CBWD5<\/jats:italic>\n                    ,\n                    <jats:italic>LRRIQ3<\/jats:italic>\n                    ,\n                    <jats:italic>TRIM64B<\/jats:italic>\n                    ,\n                    <jats:italic>SPINK5<\/jats:italic>\n                    , and\n                    <jats:italic>ZNRF2<\/jats:italic>\n                    were linked to recurrence, presenting potential therapeutic targets. Our analysis revealed 30 mutational hotspots, with significant variants in\n                    <jats:italic>KRAS<\/jats:italic>\n                    (25%, G12A, G12D, G12V),\n                    <jats:italic>MAP1A<\/jats:italic>\n                    (12%, V2300G), and\n                    <jats:italic>TP53<\/jats:italic>\n                    (8%, R175H). We identified a significant co\u2010occurrence between\n                    <jats:italic>KRAS<\/jats:italic>\n                    12 mutation and\n                    <jats:italic>PIK3CA<\/jats:italic>\n                    545 mutation. Our findings demonstrate potential driver genes and mutational hotspots associated with CRC patient, characterizing the mutational landscape related to clinical characteristics. Significantly advancing our understanding of CRC's heterogeneous nature, this study lays a solid foundation for devising more efficacious management strategies.\n                  <\/jats:p>","DOI":"10.1002\/mco2.70584","type":"journal-article","created":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T06:53:57Z","timestamp":1767941637000},"source":"Crossref","is-referenced-by-count":0,"title":["Characterization of Korean Colorectal Cancer Reveals Novel Driver Gene and Clinically Relevant Mutations"],"prefix":"10.1002","volume":"7","author":[{"given":"Junho","family":"Kang","sequence":"first","affiliation":[{"name":"Department of Research Keimyung University Dongsan Medical Center  Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong Min","family":"Lim","sequence":"additional","affiliation":[{"name":"Medical Research Institute Pusan National University  Yangsan Republic of 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Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Taeg Kyu","family":"Kwon","sequence":"additional","affiliation":[{"name":"Department of Immunology, School of Medicine Keimyung University  Daegu Republic of Korea"},{"name":"Institute of Medical Science Keimyung University  Daegu Republic of Korea"},{"name":"Center for Forensic Pharmaceutical Science Keimyung University  Daegu Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dongjun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Convergence Medicine, School of Medicine Pusan National University  Yangsan Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kihun","family":"Kim","sequence":"additional","affiliation":[{"name":"Department of Occupational and Environmental Medicine Pusan National University Yangsan Hospital  Yangsan Republic of 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