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In an aging society, sarcopenia, a condition marked by reduced muscle volume, often worsens recovery after stroke. Our study explored how mitochondria, which are abundant in muscle, could aid in stroke recovery through exercise\u2010induced migration. Using mouse models of chronic hypoperfusion and ischemia, alongside in vitro studies with rat primary cells under oxygen\u2013glucose deprivation and CoCl2 exposure, we found that treadmill exercise protected against white matter injury, myelin loss, astroglial formation, and memory deficits observed 28 days post\u2010hypoperfusion. In acute ischemia models, training reduced glial activation and post\u2010stroke complications. Exercise increased mitochondrial levels in muscle and blood, facilitating their migration between tissues via platelets. In vitro, the addition of muscle\u2010derived mitochondria enhanced the survival of neurons, astrocytes, and oligodendrocytes. Notably, platelets carrying mitochondria from treadmill\u2010trained mice significantly improved ischemic white matter injury and mitigated post\u2010stroke complications. This study highlights mitochondria as a critical part of the secretome, suggesting that muscle\u2010derived mitochondria might play a role in the protective effects of remote ischemic preconditioning. Cell\u2013cell mitochondrial migration, therefore, could offer a promising new approach to reducing post\u2010stroke complications and vascular dementia.<\/jats:p>","DOI":"10.1002\/mco2.70590","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T11:20:01Z","timestamp":1768476001000},"source":"Crossref","is-referenced-by-count":5,"title":["Mitochondrial Intercellular Transfer via Platelets After Physical Training Exerts Neuro\u2010Glial Protection Against Cerebral Ischemia"],"prefix":"10.1002","volume":"7","author":[{"given":"Toshiki","family":"Inaba","sequence":"first","affiliation":[{"name":"Department of Neurology Juntendo University School of Medicine  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3037-169X","authenticated-orcid":false,"given":"Nobukazu","family":"Miyamoto","sequence":"additional","affiliation":[{"name":"Department of Neurology Juntendo University School of Medicine  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