{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T15:08:30Z","timestamp":1790262510627,"version":"4.1.0"},"reference-count":21,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100018904","name":"Beijing Xisike Clinical Oncology Research Foundation","doi-asserted-by":"publisher","award":["Y\u2010Young2023\u20100087"],"award-info":[{"award-number":["Y\u2010Young2023\u20100087"]}],"id":[{"id":"10.13039\/100018904","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Conventional approaches for the detection and surveillance of non\u2010muscle invasive bladder cancer (NMIBC) remain invasive, burdensome, and costly. The utLIFE\u2010UC assay, designed to identify mutations and large copy number variations in urine, has demonstrated high accuracy in detecting urothelial carcinoma. Here, we assessed its efficacy in early detection of NMIBC, identifying minimal residual disease, and monitoring recurrence. Among 108 consecutive NMIBC patients evaluated, utLIFE\u2010UC exhibited a sensitivity of 90.5% in diagnosing NMIBC, with comparable performance in detecting both de novo and recurrent NMIBC. For patients undergoing repeat transurethral resection of bladder tumor (Re\u2010TURBT), the assay accurately identified all cases with residual tumor, achieving a 100% negative predictive value. Positive postoperative utLIFE\u2010UC results before the first follow\u2010up cystoscopy predicted a higher risk of future relapse. A positive test result at any time following TURBT was correlated with poorer recurrence\u2010free survival, whereas sustained negative test results indicated recurrence\u2010free status. Moreover, utLIFE\u2010UC could predict recurrence with a median lead time of 73.5 days prior to clinical confirmation. As the first prospective, longitudinal analysis of urinary tumor DNA in NMIBC, this study highlights the potential of utLIFE\u2010UC to enable earlier recurrence detection and improve risk stratification, potentially obviating unnecessary Re\u2010TURBT and surveillance cystoscopies.<\/jats:p>","DOI":"10.1002\/mco2.70592","type":"journal-article","created":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T11:19:18Z","timestamp":1768475958000},"source":"Crossref","is-referenced-by-count":1,"title":["Noninvasive Early Detection and Recurrence Monitoring for Non\u2010Muscle\u2010Invasive Bladder Cancer via Urine Tumor DNA: A Prospective Clinical Study"],"prefix":"10.1002","volume":"7","author":[{"given":"Junlong","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Urology Fudan University Shanghai Cancer Center  Shanghai China"},{"name":"Department of Oncology Shanghai Medical College Fudan University  Shanghai 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