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Currently, there is no treatment that can cure PD. Deep brain stimulation has been used to treat PD due to its good effectiveness, but there are safety issues. Therefore, noninvasive electrical stimulation (NES) may be an effective and safe strategy for the treatment of PD. Here, we performed NES treatment and NES combined with human adipose\u2010derived stem cells\u2010induced DN transplantation (NES\u2010DN) on the PD monkey model to explore the therapeutic effect of NES on PD. The results show that NES or NES\u2010DN can increase dopamine levels, improve mitochondrial dysfunction, reduce neuroinflammation, enhance synaptic function, and protect TH neurons, thereby improving the movement disorders of PD. Moreover, NES\/NES\u2010DN may exert immunomodulatory effects by regulating serpin family A member 3 in PD monkeys. Our results support the scientific basis and preclinical evidence for NES in the treatment of PD. Not only does NES alone improve PD, but NES combined with stem cell therapy can greatly enhance the therapeutic effect of PD.<\/jats:p>","DOI":"10.1002\/mco2.70595","type":"journal-article","created":{"date-parts":[[2026,1,28]],"date-time":"2026-01-28T11:36:37Z","timestamp":1769600197000},"source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic Effects of Noninvasive Electrical Stimulation in Combination Transplantation of Human Adipose\u2010Derived Stem Cells\u2010Derived Dopaminergic Neuron on the Monkey Model of Parkinson's Disease"],"prefix":"10.1002","volume":"7","author":[{"given":"Chunhui","family":"Huang","sequence":"first","affiliation":[{"name":"The Sixth Affiliated Hospital of Jinan University  Dongguan China"},{"name":"The School of Traditional Chinese Medicine Jinan University  Guangzhou China"},{"name":"State Key Laboratory of Bioactive Molecules and Druggability Assessment, Guangdong Basic Research Center of Excellence for Natural Bioactive Molecules and 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