{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,1]],"date-time":"2026-09-01T14:53:29Z","timestamp":1788274409751,"version":"build-2803163510"},"reference-count":76,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T00:00:00Z","timestamp":1769644800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Polycystic ovary syndrome (PCOS) is a well\u2010documented endocrine disorder associated with metabolic abnormalities. Research has indicated potential links between PCOS and the gut microbiome, and the presence of microbial communities in follicular fluid (FF) has been demonstrated; however, their functional interplay with metabolites has not been elucidated. This case\u2013control study involved 40 patients with PCOS and 40 controls matched for age. A comprehensive analysis of FF metabolites and microbial communities by means of metabolomics analysis and 16S rDNA sequencing was performed. Twelve metabolites and 15 microbial communities were significantly different between the PCOS and control groups. AMH and AFC were significantly associated with the majority of the differentially abundant metabolites and bacteria, suggesting a potential association between FF components and ovarian function. In this study, we found that D\u2010glucose and\n                    <jats:italic>Alicyclobacillus<\/jats:italic>\n                    were the most important variables in the metabolite model and microbial model, respectively. Mechanistically,\n                    <jats:italic>Alicyclobacillus acidoterrestris<\/jats:italic>\n                    ,\n                    <jats:italic>Terrimonas ferruginea<\/jats:italic>\n                    , or\n                    <jats:italic>Terrimonas pekingense<\/jats:italic>\n                    can efficiently utilize glucose thereby reducing FF glucose levels, which provides insights into the microbiome\u2013metabolite connection. These findings suggest a potential link among bacteria\u2013metabolite\u2013ovarian function, which could have implications for understanding the pathophysiology of PCOS and developing novel diagnostic and therapeutic strategies targeting metabolic and microbial aspects.\n                  <\/jats:p>","DOI":"10.1002\/mco2.70622","type":"journal-article","created":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T07:02:28Z","timestamp":1769756548000},"source":"Crossref","is-referenced-by-count":1,"title":["Changes in Metabolites and Microbial Communities in Follicular Fluid Associated With Ovarian Function in Patients With Polycystic Ovary Syndrome"],"prefix":"10.1002","volume":"7","author":[{"given":"Manfei","family":"Si","sequence":"first","affiliation":[{"name":"State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology Peking University Third Hospital  Beijing China"},{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital)  Beijing China"},{"name":"Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education  Beijing China"},{"name":"Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sen","family":"Yan","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology Peking University Third Hospital  Beijing China"},{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital)  Beijing China"},{"name":"Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education  Beijing China"},{"name":"Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shu","family":"Ding","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology Peking University Third Hospital  Beijing China"},{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital)  Beijing China"},{"name":"Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education  Beijing China"},{"name":"Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Liu","sequence":"additional","affiliation":[{"name":"Institute of Advanced Clinical Medicine Peking University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianglei","family":"Xiong","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology Peking University Third Hospital  Beijing China"},{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital)  Beijing China"},{"name":"Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education  Beijing China"},{"name":"Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jie","family":"Qiao","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology Peking University Third Hospital  Beijing China"},{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital)  Beijing China"},{"name":"Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education  Beijing China"},{"name":"Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyu","family":"Qi","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Female Fertility Promotion, Center for Reproductive Medicine, Department of Obstetrics and Gynecology Peking University Third Hospital  Beijing China"},{"name":"National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital)  Beijing China"},{"name":"Key Laboratory of Assisted Reproduction (Peking University), Ministry of Education  Beijing China"},{"name":"Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,1,29]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2023.07.025"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmw025"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2015.11.019"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2020.575337"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1348771"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2014.11.015"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2019.06.011"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11154-023-09819-z"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells14110787"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/09513590.2017.1371691"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-016-0704-6"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jri.2020.103083"},{"issue":"5","key":"e_1_2_13_14_1","first-page":"449","article-title":"Follicular Fluid Oxidative Stress Biomarkers and ART Outcomes in PCOS Women Undergoing In Vitro Fertilization: A Cross\u2010Sectional Study","volume":"19","author":"Gongadashetti K.","year":"2021","journal-title":"International Journal of Reproductive BioMedicine"},{"issue":"12","key":"e_1_2_13_15_1","first-page":"5583","article-title":"Follicular Fluid Redox Balance and DNA Damage According to PCOS Phenotype","volume":"27","author":"Onal M.","year":"2023","journal-title":"European Review for Medical and Pharmacological Sciences"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2022.956406"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00821"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-023-02724-z"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0214742"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cclet.2024.110794"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.960274"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsbmb.2020.105806"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fertnstert.2009.12.081"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11306-019-1481-x"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/aji.13652"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10815-023-02912-x"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.3349\/ymj.2022.0190"},{"issue":"105","key":"e_1_2_13_28_1","first-page":"2782","article-title":"Bacterial Isolation of Human Follicular Fluid and Potential Impact on In Vitro Fertilization Outcomes Medical Science","volume":"24","author":"Noor S. O.","year":"2020","journal-title":"Medical Science"},{"key":"e_1_2_13_29_1","first-page":"106","article-title":"Detection of Human Follicular Fluid Microorganisms at the Time of Oocyte Retrieval and Its Impact on In\u2010Vitro Fertilization Outcomes","author":"So N.","year":"2020","journal-title":"Prensa M\u00e9dica Argentina"},{"issue":"4","key":"e_1_2_13_30_1","first-page":"75","article-title":"Prevalence of Fungi in Human Follicular Fluid and Its Potential Impact on In Vitro Fertilization Process","volume":"11","author":"Najjar A. A.","year":"2020","journal-title":"Archives of Pharmacy Practice"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/der108"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.302"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-024-05167-x"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1210\/endocr\/bqae023"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.3390\/metabo11120845"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-024-01041-8"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jproteome.4c00937"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2025.1579477"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2025.1652954"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1426517"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10061254"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.7717\/peerj.13992"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12325-021-01789-5"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox9090867"},{"key":"e_1_2_13_45_1","volume-title":"Ketoacidosis","author":"Ghimire P.","year":"2025"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12576-024-00908-5"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2020.147054"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022029916000546"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25773"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-09-0345"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242216247"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2020.01108"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22042048"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deae270"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.resmic.2019.03.003"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13048-022-01051-8"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2018.11.001"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0509-0"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2017.06.025"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tim.2023.03.010"},{"issue":"8","key":"e_1_2_13_61_1","article-title":"The Intestinal Microbiome and Estrogen Receptor\u2010Positive Female Breast Cancer","volume":"108","author":"Kwa M.","year":"2016","journal-title":"JNCI: Journal of the National Cancer Institute"},{"key":"e_1_2_13_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-025-02120-6"},{"key":"e_1_2_13_63_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.00308-25"},{"key":"e_1_2_13_64_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.02350-25"},{"key":"e_1_2_13_65_1","doi-asserted-by":"publisher","DOI":"10.4291\/wjgp.v16.i3.107823"},{"key":"e_1_2_13_66_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7827-8-91"},{"key":"e_1_2_13_67_1","doi-asserted-by":"publisher","DOI":"10.1002\/rmb2.12609"},{"key":"e_1_2_13_68_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2024.1447397"},{"key":"e_1_2_13_69_1","doi-asserted-by":"publisher","DOI":"10.1099\/jmm.0.001741"},{"key":"e_1_2_13_70_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41551-019-0397-0"},{"key":"e_1_2_13_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-019-0600-6"},{"issue":"6","key":"e_1_2_13_72_1","article-title":"Association of Polycystic Ovarian Syndrome (PCOS) With Vaginal Microbiome Dysbiosis: A Scoping Review","volume":"16","author":"Pereira M. P.","year":"2024","journal-title":"Cureus"},{"key":"e_1_2_13_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12602-024-10262-y"},{"key":"e_1_2_13_74_1","doi-asserted-by":"publisher","DOI":"10.1128\/msphere.00887-24"},{"key":"e_1_2_13_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rbmo.2023.02.002"},{"key":"e_1_2_13_76_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/dmx013"},{"key":"e_1_2_13_77_1","doi-asserted-by":"publisher","DOI":"10.1093\/humrep\/deh098"}],"container-title":["MedComm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.70622","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mco2.70622","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.70622","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T04:51:01Z","timestamp":1770958261000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mco2.70622"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,29]]},"references-count":76,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,2]]}},"alternative-id":["10.1002\/mco2.70622"],"URL":"https:\/\/doi.org\/10.1002\/mco2.70622","archive":["Portico"],"relation":{},"ISSN":["2688-2663","2688-2663"],"issn-type":[{"value":"2688-2663","type":"print"},{"value":"2688-2663","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,29]]},"article-number":"e70622"}}