{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T06:13:14Z","timestamp":1773641594131,"version":"3.50.1"},"reference-count":67,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T00:00:00Z","timestamp":1771113600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Human telomerase reverse transcriptase (hTERT) is overexpressed in most human cancers and is an important target for cancer therapy. In this study, HS1002 was synthesized based on the amino acid sequences of gonadotropin\u2010releasing hormone (GnRH) and hTERT. This study aimed to evaluate HS1002's anticancer activity and its effects on the gonadotropin\u2010releasing hormone receptor (GnRHR) and hTERT in prostate cancer cells. HS1002 increased cytosolic calcium influx in GnRHR\u2010overexpressing HEK293 cells and showed specific molecular docking interactions with GnRHR. Compared with prostate cancer cell lines, HS1002 exhibited the highest cytotoxicity against LNCaP cells. The hTERT expression correlated with telomerase activity was suppressed by HS1002, resulting in reduced metastasis and increased apoptosis and autophagy. Additionally, HS1002 suppressed c\u2010Myc and ERK protein expressions in LNCaP cells. Furthermore, HS1002 inhibited tumor growth and downregulated hTERT expression in the xenograft model tumor tissues. HS1002\/IL\u20102\u2010pretreated PBMCs also exhibited potent cytotoxicity toward LNCaP cells. In addition, HS1002 increased the production of granzyme B and IFN\u2010\u03b3 in CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells in MC38 syngeneic mice. These findings demonstrate that HS1002 suppresses prostate cancer cell growth and induces anticancer immunity, suggesting its potential as a novel therapeutic agent against prostate cancer.\n                  <\/jats:p>","DOI":"10.1002\/mco2.70630","type":"journal-article","created":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T10:09:32Z","timestamp":1771150172000},"source":"Crossref","is-referenced-by-count":0,"title":["A Novel Peptide, HS1002, Enhances Antitumor Activity via Dual Targeting of the GnRH Receptor and Human Telomerase Reverse Transcriptase in Prostate Cancer Cells"],"prefix":"10.1002","volume":"7","author":[{"given":"Jae Hyeon","family":"Park","sequence":"first","affiliation":[{"name":"School of Pharmacy Sungkyunkwan University  Suwon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joo Chan","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Pharmacy Sungkyunkwan University  Suwon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Swati","family":"Sharma","sequence":"additional","affiliation":[{"name":"School of Pharmacy Sungkyunkwan University  Suwon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chunxue","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Sungkyunkwan University  Suwon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haeun","family":"Lee","sequence":"additional","affiliation":[{"name":"School of Pharmacy Sungkyunkwan University  Suwon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hyun\u2010Ju","family":"Park","sequence":"additional","affiliation":[{"name":"School of Pharmacy Sungkyunkwan University  Suwon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7657-3970","authenticated-orcid":false,"given":"Hyung Sik","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Pharmacy Sungkyunkwan University  Suwon Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,15]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12030558"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2017.104"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2019.00332"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12929-018-0422-8"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-022-02678-9"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.4081\/oncol.2013.e6"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yfrne.2008.07.001"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00187"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.682492"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.4161\/onci.20426"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-18-0454"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1208\/s12248-015-9769-x"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/1757-2215-3-26"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2004-0017"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2017.00274"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-19109-w"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2019.00370"},{"issue":"3","key":"e_1_2_12_19_1","first-page":"1471","article-title":"Optimized Protocols for \u0393\u03b4 T Cell Expansion and Lentiviral Transduction","volume":"19","author":"Wang R. N.","year":"2019","journal-title":"Molecular Medicine Reports"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.exphem.2006.10.006"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-35948-9"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1210\/edrv-7-1-44"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.15406\/mojap.2016.02.00063"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2003-0002"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2013.208"},{"issue":"5","key":"e_1_2_12_26_1","first-page":"593","article-title":"GnRH Agonist Inhibits Human Telomerase Reverse Transcriptase mRNA Expression in Endometrial Cancer Cells","volume":"10","author":"Nagai N.","year":"2002","journal-title":"International Journal of Molecular Medicine"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0304-3835(98)00270-5"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc2393"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.3109\/07357907.2011.629381"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-13-1863"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2017.04.016"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-019-1037-8"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.31225"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.20960"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-0594"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-09-0924"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ju.0000074653.22766.c8"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-021-00704-3"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201902147R"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/bip.21521"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21249511"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20225548"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01042-7"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-019-0372-0"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1177\/1947601910379132"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/6010"},{"issue":"6","key":"e_1_2_12_47_1","first-page":"6833","article-title":"The Downregulation of c\u2010Myc and Its Target Gene hTERT Is Associated with the Antiproliferative Effects of Baicalin on HL\u201060 Cells","volume":"14","author":"Ren X.","year":"2017","journal-title":"Oncology Letters"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2017.09.072"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0055730"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.19.13085"},{"issue":"11","key":"e_1_2_12_51_1","first-page":"2684","article-title":"Nuclear Import of hTERT Requires a Bipartite Nuclear Localization Signal and Akt\u2010Mediated Phosphorylation","volume":"125","author":"Chung J.","year":"2012","journal-title":"Journal of Cell Science"},{"issue":"1","key":"e_1_2_12_52_1","first-page":"97","article-title":"Disruption of an hTERT\u2013mTOR\u2013RAPTOR Protein Complex by a Phytochemical Perillyl Alcohol and Rapamycin","volume":"375","author":"Sundin T.","year":"2013","journal-title":"Molecular and Cellular Biochemistry"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2017.01.019"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.836800"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.embor.7401099"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.1.181"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12865-021-00435-7"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xpro.2022.101590"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.722916"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13115"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2011.300"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.23194"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20081823"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-08-0197"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2008.06677.x"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00044-021-02755-0"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2022.175192"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-00904-4"}],"container-title":["MedComm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.70630","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mco2.70630","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.70630","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T05:16:58Z","timestamp":1773638218000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mco2.70630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,15]]},"references-count":67,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/mco2.70630"],"URL":"https:\/\/doi.org\/10.1002\/mco2.70630","archive":["Portico"],"relation":{},"ISSN":["2688-2663","2688-2663"],"issn-type":[{"value":"2688-2663","type":"print"},{"value":"2688-2663","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,15]]},"article-number":"e70630"}}