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However, the mechanisms by which FXR modulates neutrophil\u2010mediated mucosal inflammation in IBD remain elusive. Here, we demonstrated that FXR expression is markedly decreased in neutrophils from patients with active IBD.\n                    <jats:italic>Fxr<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice exhibited exacerbated colitis following DSS insults or\n                    <jats:italic>Citrobacter rodentium<\/jats:italic>\n                    infection, evidenced by heightened neutrophil\u2010driven immune responses including increased neutrophil infiltration and neutrophil extracellular trap (NET) formation. Adoptive transfer of\n                    <jats:italic>Fxr<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    neutrophils into WT recipients exacerbated DSS\u2010induced intestinal inflammation, indicating that FXR suppresses the pathogenic activity of neutrophils in a neutrophil\u2010intrinsic manner. An ex vivo functional assay revealed that\n                    <jats:italic>Fxr<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    neutrophils display elevated ROS production, NET formation, and migratory capacity upon inflammatory challenge. Mechanistically, RNA\u2010sequencing and functional assays revealed enhanced mTORC1 signaling and glycolysis in\n                    <jats:italic>Fxr<\/jats:italic>\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    neutrophils. Consistently, pharmacological activation of FXR with INT\u2010747 significantly restrained the mTORC1\u2010glycolysis\u2010mediated proinflammatory responses in neutrophils from IBD patients. Our findings identify FXR as a critical regulator of neutrophil\u2010mediated mucosal inflammation via the mTORC1\u2010glycolysis pathway, highlighting its therapeutic potential in IBD.\n                  <\/jats:p>","DOI":"10.1002\/mco2.70637","type":"journal-article","created":{"date-parts":[[2026,2,8]],"date-time":"2026-02-08T08:16:41Z","timestamp":1770538601000},"source":"Crossref","is-referenced-by-count":2,"title":["Dysregulation of Farnesoid X Receptor on Neutrophil Homeostasis Exacerbates Intestinal Inflammation via the mTORC1\u2010Glycolysis Signaling Pathway"],"prefix":"10.1002","volume":"7","author":[{"given":"Dengfeng","family":"Kang","sequence":"first","affiliation":[{"name":"Center for Inflammatory Bowel Disease Research and Department of Gastroenterology Shanghai Tenth People's Hospital, Tongji University School of Medicine  Shanghai 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