{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T06:57:53Z","timestamp":1776236273184,"version":"3.50.1"},"reference-count":109,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,4,2]],"date-time":"2026-04-02T00:00:00Z","timestamp":1775088000000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Autoimmune diseases (AIDs) arise from complex immune dysregulations involving multiple immune cell types, cytokines, and molecular mediators. Among these, microRNAs (miRNAs) have recently emerged as key regulators of leukocyte processes and are frequently dysregulated in AIDs. However, their role in disease pathophysiology remains poorly understood. In this study, we performed a comprehensive analysis of miRNA expression in three immune populations, namely, CD14\n                    <jats:sup>+<\/jats:sup>\n                    monocytes, neutrophils, and CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells, in multiple sclerosis (MS) and type 1 diabetes (T1D), two prototypical AIDs. Our results reveal distinct patterns of miRNA dysregulation in each cell type, with monocytes from T1D patients showing enhanced M1 polarization and supporting inflammatory vascular damage. On the other hand, CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cells from MS patients show profound alterations related to CD8\n                    <jats:sup>+<\/jats:sup>\n                    T cell\u2010fate commitment, apoptosis regulation, and migratory capacity. Notably, we identified miRNAs that regulate key transcription factors such as FOXP3, IRF4, and ROR\u03b3t, potentially shaping T cell differentiation programs. Our results suggest that miRNA networks play a central role in orchestrating disease\u2010specific dysregulation in AIDs. By elucidating these intricate regulatory mechanisms, our study provides a foundation for future therapeutic strategies targeting miRNAs in autoimmunity.\n                  <\/jats:p>","DOI":"10.1002\/mco2.70647","type":"journal-article","created":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T06:47:36Z","timestamp":1775198856000},"source":"Crossref","is-referenced-by-count":0,"title":["Multi\u2010Omics Analysis in Autoimmunity: Identification of MicroRNA Regulatory Networks and Cell\u2010Type\u2010Specific Dysregulations in Multiple Sclerosis and Type 1 Diabetes"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5520-4631","authenticated-orcid":false,"given":"Jacopo","family":"Ronchi","sequence":"first","affiliation":[{"name":"School of Medicine and Surgery University of Milano\u2010Bicocca  Monza MB Italy"},{"name":"PhD Program in Neuroscience Medicine and Surgery Department University of Milano\u2010Bicocca  Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Rigolio","sequence":"additional","affiliation":[{"name":"School of Medicine and Surgery University of Milano\u2010Bicocca  Monza MB Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide Maria","family":"Trevisan","sequence":"additional","affiliation":[{"name":"School of Medicine and Surgery University of Milano\u2010Bicocca  Monza MB Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Papagna","sequence":"additional","affiliation":[{"name":"School of Medicine and Surgery University of Milano\u2010Bicocca  Monza MB Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Angela","family":"Stabilini","sequence":"additional","affiliation":[{"name":"Diabetes Research Institute IRCCS San Raffaele Scientific Institute  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina","family":"Gallinaro","sequence":"additional","affiliation":[{"name":"Department of Neurosciences Biomedicine and Movement Sciences University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Letizia","family":"Fusco","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS San Gerardo Dei Tintori  Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martina Gaia","family":"Cogo","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS San Gerardo Dei Tintori  Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guido","family":"Cavaletti","sequence":"additional","affiliation":[{"name":"School of Medicine and Surgery University of Milano\u2010Bicocca  Monza MB Italy"},{"name":"Fondazione IRCCS San Gerardo Dei Tintori  Monza Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giovanni","family":"Malerba","sequence":"additional","affiliation":[{"name":"Department of Neurosciences Biomedicine and Movement Sciences University of Verona  Verona Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Battaglia","sequence":"additional","affiliation":[{"name":"Diabetes Research Institute IRCCS San Raffaele Scientific Institute  Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4481-1900","authenticated-orcid":false,"given":"Maria","family":"Foti","sequence":"additional","affiliation":[{"name":"School of Medicine and Surgery University of Milano\u2010Bicocca  Monza MB Italy"},{"name":"BicOMICs University of Milano\u2010Bicocca  Monza MB Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,4,2]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-017-1215-1"},{"key":"e_1_2_11_3_1","first-page":"147","volume-title":"Advances in Genetics","author":"Sun Y. V.","year":"2016"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0038-1649502"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.4161\/pri.23499"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1212\/WNL.0000000000000560"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2023-075681"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(23)00223-4"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2020.102438"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.3109\/08830185.2014.954698"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1001860"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2015.08.043"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.02.008"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-31135-4"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.117.309660"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.7150\/jca.83466"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2022.913791"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.753884"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2199-8-79"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S299234"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1590\/1678-4685-gmb-2021-0160"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0159565"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20230321"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI130426"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.13-247288"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.abi4613"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002083"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202048627"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2014.04.037"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkt666"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.09-134965"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506654102"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1538\/expanim.20-0160"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.13231"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12872-023-03481-8"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2019.105871"},{"key":"e_1_2_11_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.12.013"},{"issue":"2","key":"e_1_2_11_38_1","first-page":"839","article-title":"MicroRNA\u2010140\u20105p Aggravates Hypertension and Oxidative Stress of Atherosclerosis via Targeting Nrf2 and Sirt2","volume":"43","author":"Liu Q. Q.","year":"2019","journal-title":"International Journal of Molecular Medicine"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-024-02736-y"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2014.03.026"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2021.08.027"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajog.2017.10.040"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/9931742"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0506580102"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/75556"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae1072"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac1070"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/bmt.2014.57"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI140755"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/16476"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.133686"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2011.03.018"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0276-y"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-017-0565-4"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1238"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-9822(99)00253-5"},{"issue":"127","key":"e_1_2_11_57_1","first-page":"235","article-title":"S100A1 Promotes Cell Proliferation and Migration and Is Associated With Lymph Node Metastasis in Ovarian Cancer","volume":"23","author":"Tian T.","year":"2017","journal-title":"Discovery Medicine"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioadv\/vbac016"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200939412"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.4463"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.imbio.2012.05.010"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2012.63"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/ibd.21476"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201344279"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellimm.2011.02.008"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.03.001"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.215939.113"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2021005726"},{"key":"e_1_2_11_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-800178-3.00007-5"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S256347"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2606"},{"issue":"19","key":"e_1_2_11_72_1","first-page":"4292","article-title":"Coronin\u20101C and RCC2 Guide Mesenchymal Migration by Trafficking Rac1 and Controlling GEF Exposure","volume":"127","author":"Williamson R. C.","year":"2014","journal-title":"Journal of Cell Science"},{"issue":"4","key":"e_1_2_11_73_1","first-page":"842","article-title":"MiR\u2010146a Restoration Suppresses Triple\u2010Negative Breast Cancer Cell Migration: A Bioinformatic and in Vitro Study","volume":"12","author":"Tebbi L.","year":"2022","journal-title":"Advanced Pharmaceutical Bulletin"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V89.5.1708"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.285718"},{"key":"e_1_2_11_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13731-z"},{"key":"e_1_2_11_77_1","doi-asserted-by":"publisher","DOI":"10.1212\/NXI.0000000000200075"},{"key":"e_1_2_11_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2010.01.024"},{"key":"e_1_2_11_79_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43042-024-00543-0"},{"key":"e_1_2_11_80_1","doi-asserted-by":"publisher","DOI":"10.3109\/00207454.2012.678444"},{"key":"e_1_2_11_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.arcmed.2019.07.002"},{"key":"e_1_2_11_82_1","doi-asserted-by":"publisher","DOI":"10.1111\/1753-0407.12163"},{"key":"e_1_2_11_83_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-63282-3"},{"key":"e_1_2_11_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2009.69"},{"key":"e_1_2_11_85_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7437281"},{"key":"e_1_2_11_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.msard.2021.103078"},{"key":"e_1_2_11_87_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2016.4509"},{"key":"e_1_2_11_88_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-021-04268-4"},{"key":"e_1_2_11_89_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.103977"},{"key":"e_1_2_11_90_1","article-title":"Single Cell Multiomics Reveals Drivers of Metabolic Dysfunction\u2010associated Steatohepatitis [Preprint]","author":"Elison W.","year":"2025","journal-title":"medRxiv"},{"key":"e_1_2_11_91_1","volume-title":"R: A Language and Environment for Statistical Computing","author":"R Core Team","year":"2021"},{"key":"e_1_2_11_92_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btq431"},{"key":"e_1_2_11_93_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btn647"},{"key":"e_1_2_11_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3947"},{"key":"e_1_2_11_95_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12859-016-1323-z"},{"key":"e_1_2_11_96_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bts034"},{"key":"e_1_2_11_97_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkv007"},{"key":"e_1_2_11_98_1","doi-asserted-by":"publisher","DOI":"10.1111\/1467-9868.00346"},{"key":"e_1_2_11_99_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky509"},{"key":"e_1_2_11_100_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac395"},{"key":"e_1_2_11_101_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.05005"},{"key":"e_1_2_11_102_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky1141"},{"key":"e_1_2_11_103_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gks596"},{"key":"e_1_2_11_104_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btw777"},{"key":"e_1_2_11_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.4091"},{"key":"e_1_2_11_106_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.01.004"},{"key":"e_1_2_11_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.01.041"},{"key":"e_1_2_11_108_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaf018"},{"key":"e_1_2_11_109_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad841"},{"key":"e_1_2_11_110_1","doi-asserted-by":"publisher","DOI":"10.1097\/MIB.0000000000000848"}],"container-title":["MedComm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.70647","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mco2.70647","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.70647","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T05:58:39Z","timestamp":1776232719000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mco2.70647"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4]]},"references-count":109,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4]]}},"alternative-id":["10.1002\/mco2.70647"],"URL":"https:\/\/doi.org\/10.1002\/mco2.70647","archive":["Portico"],"relation":{},"ISSN":["2688-2663","2688-2663"],"issn-type":[{"value":"2688-2663","type":"print"},{"value":"2688-2663","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4]]},"article-number":"e70647"}}