{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:39:06Z","timestamp":1792175946347,"version":"4.4.0"},"reference-count":247,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"vor","delay-in-days":4,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["22173118"],"award-info":[{"award-number":["22173118"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82304553"],"award-info":[{"award-number":["82304553"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373064"],"award-info":[{"award-number":["82373064"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82474009"],"award-info":[{"award-number":["82474009"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2022JJ80104"],"award-info":[{"award-number":["2022JJ80104"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2023JJ40952"],"award-info":[{"award-number":["2023JJ40952"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004735","name":"Natural Science Foundation of Hunan Province","doi-asserted-by":"publisher","award":["2024JJ6618"],"award-info":[{"award-number":["2024JJ6618"]}],"id":[{"id":"10.13039\/501100004735","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>The NLRP3 inflammasome is a pivotal signaling platform of the innate immune system that senses a broad spectrum of microbial, metabolic, and environmental danger signals. Its activation leads to the recruitment of ASC and caspase\u20101, driving the maturation of pro\u2010inflammatory cytokines interleukin (IL)\u20101\u03b2 and IL\u201018 as well as the execution of pyroptosis. Aberrant or persistent activation of NLRP3 has been implicated in the pathogenesis of numerous disorders, including autoinflammatory syndromes, metabolic and cardiovascular diseases, neurodegenerative conditions, and cancers. In this review, we provide an updated overview of the molecular mechanisms governing NLRP3 activation and regulation, with particular focus on ion flux, mitochondrial damage, lysosomal rupture, reactive oxygen species, and post\u2010translational modifications. We further discuss negative regulatory pathways that maintain inflammasome homeostasis and prevent excessive inflammation. Finally, we summarize recent advances in therapeutic strategies targeting the NLRP3 inflammasome, ranging from direct inhibitors and allosteric modulators to biologics and repurposed drugs, and highlight their translational potential. Understanding the fine balance between NLRP3 activation and inhibition offers new opportunities for therapeutic intervention in a wide array of inflammatory and immune\u2010related diseases.<\/jats:p>","DOI":"10.1002\/mco2.70660","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T18:46:45Z","timestamp":1772995605000},"source":"Crossref","is-referenced-by-count":34,"title":["The NLRP3 Inflammasome: Mechanisms of Activation, Regulation, and Therapeutic Opportunities"],"prefix":"10.1002","volume":"7","author":[{"given":"Chan","family":"Zou","sequence":"first","affiliation":[{"name":"Center For Clinical Pharmacology Third Xiangya Hospital Central South University Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilong","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Xiangya Hospital Central South University  Changsha China"},{"name":"The Hunan Institute of Pharmacy Practice and Clinical Research  Changsha China"},{"name":"National Clinical Research Center for Geriatric Disease Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Li","sequence":"additional","affiliation":[{"name":"Xiangya School of Pharmaceutical Science Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Hematology and Critical Care Medicine the Third Xiangya Hospital Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dongshen","family":"Cao","sequence":"additional","affiliation":[{"name":"Xiangya School of Pharmaceutical Science Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5930-586X","authenticated-orcid":false,"given":"Guoping","family":"Yang","sequence":"additional","affiliation":[{"name":"Center For Clinical Pharmacology Third Xiangya Hospital Central South University Changsha China"},{"name":"Xiangya School of Pharmaceutical Science Central South University  Changsha China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,3,5]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-065X.2000.917309.x"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/intimm\/dxp017"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2008.02.005"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng756"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0165-0"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2023.03.003"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms9761"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02682-y"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2016.10.007"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0901363"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2017.08.017"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.05.016"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.cdd.4402195"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.609441"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.04.032"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11588"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1117765109"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-00227-x"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1812744115"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1631"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0011765"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-031023-125300"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0761-3"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2022.10.021"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01355-3"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.59704"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1109938"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43556-024-00179-x"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-immunol-081022-021207"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-025-01224-x"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-022-01185-3"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2019.101254"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13280"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-021-00780-y"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms15986"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-021-00670-3"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11986"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12903-024-04936-w"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI148548"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1042\/BCJ20220364"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbalip.2019.04.001"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3804"},{"key":"e_1_2_12_44_1","article-title":"Acidosis Licenses the NLRP3 Inflammasome\u2010Inhibiting Effects of Beta\u2010Hydroxybutyrate and Short\u2010Chain Carboxylic Acids","author":"Mank M. M.","year":"2025","journal-title":"BioRxiv"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2025.01.028"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2025.116084"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2023.12.029"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2025.11.002"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2012.07.007"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.111537"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13161365"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-05570-8"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1435892"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1295-z"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25169018"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1101\/2021.09.12.459968"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2121353119"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11929"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20172222"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abn7583"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-019-0277-7"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10558"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201545523"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15514"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.201545772"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.01.012"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01423-2"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0548-1"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2016.29"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11481-024-10101-5"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2015.6615"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.08.021"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-019-0406-7"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06568-5"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.febslet.2014.10.025"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5738"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107604"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1529756"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/4323281"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1692"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2023.102691"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2019.09.013"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-023-02327-2"},{"key":"e_1_2_12_84_1","first-page":"2021","article-title":"MicroRNA\u2010223 Suppresses IL\u20101\u03b2 and TNF\u2010\u03b1 Production in Gouty Inflammation by Targeting the NLRP3 Inflammasome","volume":"12","author":"Zhang Q.\u2010B.","year":"2021","journal-title":"Frontiers in Pharmacology"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jbc.2024.107386"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-020-00688-6"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.645549"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.31083\/FBL25970"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13727"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.11.009"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20132486"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.01054"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2016.09.008"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20162040"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI90897"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.202350382"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05321-2"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-44203-0"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1459"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.15252\/embj.2023113481"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-022-04211-7"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-025-01284-9"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aas8995"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2023.11.015"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.1980"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2215"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.628168"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.202911"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3MR0720-513R"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2015.07.018"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00275"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12290"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.11.047"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12608"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2022"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-025-01284-9"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.618231"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(04)00046-9"},{"key":"e_1_2_12_119_1","first-page":"444","article-title":"Discovery of a Novel Missense Variant in NLRP3 Causing Atypical Cryopyrin\u2010Associated Periodic Syndromes with Hearing Loss as the Primary Presentation","volume":"76","author":"Birk\u2010Bachar M.","year":"2024","journal-title":"Responsive to Anti\u2010Interleukin\u20101 Therapy, Arthritis and Rheumatology"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204991"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20201466"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202154339"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-44990-0"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.75166"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adf4699"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.40208"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1702946114"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41004"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2011.152728"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23687"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2009.108936"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20231200"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1124\/pharmrev.122.000629"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.1c00681"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41413-018-0016-9"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/kem372"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.1136\/ard.2008.106989"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature04516"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrdp.2016.72"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.joca.2018.02.901"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1012743108"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1111101108"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-018-1664-2"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/4139048"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.02.004"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41245"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(20)30065-5"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.093252"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2011.03462.x"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114919"},{"key":"e_1_2_12_151_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c00504"},{"key":"e_1_2_12_152_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.285"},{"key":"e_1_2_12_153_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI98642"},{"key":"e_1_2_12_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-023-01148-7"},{"key":"e_1_2_12_155_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1405"},{"key":"e_1_2_12_156_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0802173"},{"key":"e_1_2_12_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2020.145299"},{"key":"e_1_2_12_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2021.10.002"},{"key":"e_1_2_12_159_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1FO03360C"},{"key":"e_1_2_12_160_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-26775-w"},{"key":"e_1_2_12_161_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1471"},{"key":"e_1_2_12_162_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25116078"},{"key":"e_1_2_12_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.116581"},{"key":"e_1_2_12_164_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph16091211"},{"key":"e_1_2_12_165_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.012219"},{"key":"e_1_2_12_166_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-023-01014-0"},{"key":"e_1_2_12_167_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000931"},{"key":"e_1_2_12_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bioactmat.2023.12.024"},{"key":"e_1_2_12_169_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-014-0415-z"},{"key":"e_1_2_12_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.12.037"},{"key":"e_1_2_12_171_1","doi-asserted-by":"publisher","DOI":"10.1097\/FJC.0000000000000658"},{"key":"e_1_2_12_172_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.119.015513"},{"key":"e_1_2_12_173_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200903124"},{"key":"e_1_2_12_174_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-94850-w"},{"key":"e_1_2_12_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmb.2021.167309"},{"key":"e_1_2_12_176_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c01250"},{"key":"e_1_2_12_177_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.13576"},{"key":"e_1_2_12_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ab.2021.114510"},{"key":"e_1_2_12_179_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20171419"},{"key":"e_1_2_12_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2018.12.031"},{"key":"e_1_2_12_181_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13065-024-01178-3"},{"key":"e_1_2_12_182_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40360-025-00851-0"},{"key":"e_1_2_12_183_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c01857"},{"key":"e_1_2_12_184_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3806"},{"key":"e_1_2_12_185_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41435-020-0104-x"},{"key":"e_1_2_12_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2025.06.005"},{"key":"e_1_2_12_187_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1722041115"},{"key":"e_1_2_12_188_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1178662"},{"key":"e_1_2_12_189_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2024.114609"},{"key":"e_1_2_12_190_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.888392"},{"key":"e_1_2_12_191_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2017.00278"},{"key":"e_1_2_12_192_1","first-page":"414","article-title":"ATP Release and Purinergic Signaling in NLRP3 Inflammasome Activation","volume":"3","author":"Gombault A.","year":"2012","journal-title":"Frontiers in Immunology"},{"key":"e_1_2_12_193_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10626-x"},{"key":"e_1_2_12_194_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.591803"},{"key":"e_1_2_12_195_1","doi-asserted-by":"publisher","DOI":"10.1039\/D4CC06321J"},{"key":"e_1_2_12_196_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2023.2187957"},{"key":"e_1_2_12_197_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.13789"},{"key":"e_1_2_12_198_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaf372"},{"key":"e_1_2_12_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2022.04.003"},{"key":"e_1_2_12_200_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c01398"},{"key":"e_1_2_12_201_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1716095115"},{"key":"e_1_2_12_202_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2009680117"},{"key":"e_1_2_12_203_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02578"},{"key":"e_1_2_12_204_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c02098"},{"key":"e_1_2_12_205_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c01341"},{"key":"e_1_2_12_206_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04947-6"},{"key":"e_1_2_12_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2024.116760"},{"key":"e_1_2_12_208_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1204143"},{"key":"e_1_2_12_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.107358"},{"key":"e_1_2_12_210_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b01624"},{"key":"e_1_2_12_211_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.739953"},{"key":"e_1_2_12_212_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2022.09.014"},{"key":"e_1_2_12_213_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2020.07.016"},{"key":"e_1_2_12_214_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-025-05699-5"},{"key":"e_1_2_12_215_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-70513-0"},{"key":"e_1_2_12_216_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2023.115784"},{"key":"e_1_2_12_217_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c01782"},{"key":"e_1_2_12_218_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmech.2022.114338"},{"key":"e_1_2_12_219_1","doi-asserted-by":"publisher","DOI":"10.1080\/08923973.2021.1925293"},{"key":"e_1_2_12_220_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201708689"},{"key":"e_1_2_12_221_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-182289"},{"key":"e_1_2_12_222_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.822833"},{"key":"e_1_2_12_223_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-019-0278-6"},{"key":"e_1_2_12_224_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000354"},{"key":"e_1_2_12_225_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04467-w"},{"key":"e_1_2_12_226_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschembio.1c00218"},{"key":"e_1_2_12_227_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2018.149"},{"key":"e_1_2_12_228_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsomega.2c00125"},{"key":"e_1_2_12_229_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2017.12.054"},{"key":"e_1_2_12_230_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.9b00433"},{"key":"e_1_2_12_231_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.201700270"},{"key":"e_1_2_12_232_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c00175"},{"key":"e_1_2_12_233_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2020.127560"},{"key":"e_1_2_12_234_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c00149"},{"key":"e_1_2_12_235_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c00894"},{"key":"e_1_2_12_236_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.13789"},{"key":"e_1_2_12_237_1","doi-asserted-by":"publisher","DOI":"10.1002\/mds.30307"},{"key":"e_1_2_12_238_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-024-01261-8"},{"key":"e_1_2_12_239_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2023.2239502"},{"key":"e_1_2_12_240_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2025.04.007"},{"key":"e_1_2_12_241_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2023.09.016"},{"key":"e_1_2_12_242_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-018-1664-2"},{"key":"e_1_2_12_243_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2020.127021"},{"key":"e_1_2_12_244_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules26133975"},{"key":"e_1_2_12_245_1","first-page":"2021","article-title":"Oridonin: A Review of Its Pharmacology, Pharmacokinetics and Toxicity","volume":"12","author":"Li X.","year":"2021","journal-title":"Frontiers in Pharmacology"},{"key":"e_1_2_12_246_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1204143"},{"key":"e_1_2_12_247_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01409"},{"key":"e_1_2_12_248_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-023-01105-7"}],"container-title":["MedComm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.70660","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mco2.70660","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.70660","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,16]],"date-time":"2026-03-16T05:18:23Z","timestamp":1773638303000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mco2.70660"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":247,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,3]]}},"alternative-id":["10.1002\/mco2.70660"],"URL":"https:\/\/doi.org\/10.1002\/mco2.70660","archive":["Portico"],"relation":{},"ISSN":["2688-2663","2688-2663"],"issn-type":[{"value":"2688-2663","type":"print"},{"value":"2688-2663","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,3]]},"article-number":"e70660"}}