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This open\u2010label, multicenter, single\u2010arm Phase II study evaluated lucitanib plus the anti\u2010programmed cell death 1 (PD\u20101) antibody toripalimab in patients with advanced solid tumors refractory to standard therapies. Patients received lucitanib (10\u00a0mg) once daily plus toripalimab (240\u00a0mg) every 3 weeks until progression or unacceptable toxicity. The primary endpoint was investigator\u2010assessed objective response rate (ORR) and secondary endpoints included disease control rate, duration of response, progression\u2010free survival (PFS), overall survival, and safety. Among 131 patients across four cohorts (PD\u20101\u2013treated recurrent\/metastatic nasopharyngeal carcinoma [NPC], PD\u20101\u2013na\u00efve NPC, recurrent\/metastatic endometrial cancer [EC], and other tumors), ORR was 34.1%, 45.8%, 38.5%, and 13.5%, respectively. Median PFS was 4.2 months (95% confidence interval [CI], 4.1\u20135.6), 6.5 months (95% CI, 4.0\u2013not estimable [NE]), 5.6 months (95% CI, 2.78\u201311.21), and 9.7 months (95% CI, 5.4\u2013NE). The most common Grade \u2265 3 treatment\u2010related adverse events were hypertension (37.4%), proteinuria (10.7%), and thrombocytopenia (10.7%). Lucitanib plus toripalimab showed encouraging antitumor activity with manageable safety in heavily pretreated advanced solid tumors, supporting further randomized evaluation, particularly in NPC and EC.<\/jats:p>\n                  <jats:p>\n                    <jats:bold>Trial Registration<\/jats:bold>\n                    : Chinese Clinical Trial Registry Identifier: ChiCTR2400087935\n                  <\/jats:p>","DOI":"10.1002\/mco2.70672","type":"journal-article","created":{"date-parts":[[2026,3,12]],"date-time":"2026-03-12T05:16:58Z","timestamp":1773292618000},"source":"Crossref","is-referenced-by-count":0,"title":["Safety and Efficacy of Lucitanib Plus Toripalimab in Advanced Solid Tumors Refractory to Standard Therapies: An Open\u2010Label, Multicenter, Phase II Study"],"prefix":"10.1002","volume":"7","author":[{"given":"Ting","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Medical Oncology, State Key Laboratory of Oncology in South China, Guangdong Key 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