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Spices, known for their culinary and medicinal qualities, have emerged as promising sources of antimicrobial agents due to their rich content of potent bioactive phytochemicals. Compounds such as flavonoids, phenolics, alkaloids, and terpenoids exhibit strong antibacterial, antifungal, and antiviral activities. These phytochemicals target microbial cell walls, membranes, and metabolic processes, effectively inhibiting pathogen growth and survival. Additionally, their ability to disrupt biofilms and synergize with conventional antibiotics enhances their potential to counter resistance mechanisms. This review examines the mechanisms and dissemination of antimicrobial resistance, the antimicrobial properties of spices and their phytochemicals, focusing on their modes of action, efficacy against multidrug\u2010resistant pathogens, specific extraction methods for each phytochemical, synergism with traditional antibiotics, safety and toxicological concerns, future research directions, and challenges in the widespread use of these spice\u2010derived compounds. 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