{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,15]],"date-time":"2026-04-15T06:58:10Z","timestamp":1776236290309,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T00:00:00Z","timestamp":1773792000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82572459"],"award-info":[{"award-number":["82572459"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>This study aimed to investigate the heterogeneity of treatment effect for intra\u2010aortic balloon pump (IABP) across various lactate trajectories in patients with acute myocardial infarction\u2010related cardiogenic shock (AMICS) supported by veno\u2010arterial extracorporeal membrane oxygenation (VA\u2010ECMO). Retrospective data from the China Extracorporeal Life Support Registry included AMICS patients who received VA\u2010ECMO. The latent class growth model was used to identify distinct lactate trajectories. The primary outcome was in\u2010hospital mortality. Baseline characteristics and outcomes were compared across trajectory classes, and the heterogeneity of treatment effect for IABP was assessed. Among 1264 patients, three lactate trajectories were identified. Compared with Class 1, both Class 2 (odds ratio [OR] 2.03, 95% confidence interval [CI] 1.54\u20132.67) and Class 3 (OR 3.99, 95% CI 2.77\u20135.78) had significantly higher in\u2010hospital mortality. Moreover, heterogeneity of treatment effect across the classes was found. IABP use was associated with increased risks of in\u2010hospital mortality and multiple complications (bleeding, renal, metabolic, and infection) in Class 1, whereas no associations were observed in Class 2 or Class 3, except for a higher risk of infection in Class 2. In summary, lactate trajectories can stratify mortality risk in AMICS patients receiving VA\u2010ECMO support and reflect heterogeneous responses to IABP treatment.<\/jats:p>","DOI":"10.1002\/mco2.70698","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T08:46:57Z","timestamp":1773823617000},"source":"Crossref","is-referenced-by-count":0,"title":["Heterogeneity of Treatment Effect for Intra\u2010Aortic Balloon Pump Use Across Lactate Trajectories in Cardiogenic Shock Patients Supported by VA\u2010ECMO: An Analysis of the Chinese Extracorporeal Life Support Registry"],"prefix":"10.1002","volume":"7","author":[{"given":"Xiang\u2010Jie","family":"Duan","sequence":"first","affiliation":[{"name":"Department of Intensive Care Unit The First Affiliated Hospital of Jinan University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo","family":"Wang","sequence":"additional","affiliation":[{"name":"Medical Education Center of Jinan University  Guangzhou China"},{"name":"Department of Emergency Medicine, Research Center of Cardiovascular Disease, the People's Hospital of Guangxi Zhuang Autonomous Region Guangxi Academy of Medical Sciences  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cheng\u2010Long","family":"Li","sequence":"additional","affiliation":[{"name":"Center For Cardiac Intensive Care, Beijing Anzhen Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Research Center of Cardiovascular Disease, the People's Hospital of Guangxi Zhuang Autonomous Region Guangxi Academy of Medical Sciences  Nanning China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit The First Affiliated Hospital of Jinan University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie\u2010Lian","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit The First Affiliated Hospital of Jinan University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun\u2010Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit The First Affiliated Hospital of Jinan University  Guangzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao\u2010Tong","family":"Hou","sequence":"additional","affiliation":[{"name":"Center For Cardiac Intensive Care, Beijing Anzhen Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hai\u2010Yan","family":"Yin","sequence":"additional","affiliation":[{"name":"Department of Intensive Care Unit The First Affiliated Hospital of Jinan University  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