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Despite therapeutic HPV vaccines having been investigated, the lack of appreciable efficacy highlights the urgent need to develop more effective strategies. Here, we developed an immuno\u2010oncotherapy for HPV\u2010induced tumors based on an adenoviral (Ad)\u2010vectored therapeutic vaccine that contains concatemeric T cell epitopes, and evaluated oncolytic viruses (OV) as potential approach to enhance vaccine efficacy. We observed that the therapeutic vaccine encoding the HPV E7 oncoprotein epitope (Ad\u2010E7P) significantly inhibited tumor growth in HPV\u2010induced murine models by inducing systemic antitumor CD8+T cell responses and promoting the formation of tertiary lymphoid structures in peritumoral regions. We then evaluated the potential of combining the vaccine with an interleukin\u201012 (IL\u201012)\u2013armed oncolytic herpesvirus (SKV\u2010012) in preclinical models. The combination therapy elicited potent antitumor responses by inducing antigen\u2010specific T\u2010cell expansion, remodeling the tumor microenvironment, and generating immune memory, which led to tumor clearance. Overall, these findings support that the vaccine synergizes with the OV as an effective approach to enhance antitumor immunity in HPV\u2010associated malignancies.<\/jats:p>","DOI":"10.1002\/mco2.70737","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T06:51:07Z","timestamp":1776149467000},"source":"Crossref","is-referenced-by-count":0,"title":["Combination of Vaccine With IL\u201012\u2010Armed Oncolytic Virus SKV\u2010012 Synergistically Potentiates Immune Responses in HPV\u2010Associated Malignancies"],"prefix":"10.1002","volume":"7","author":[{"given":"Nian","family":"Yang","sequence":"first","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center Research Unit of Gene and Immunotherapy Chinese Academy of Medical Sciences Collaborative Innovation Center of Biotherapy West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Long","family":"Xu","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Biotherapy and Cancer Center Research Unit of Gene and Immunotherapy Chinese Academy of Medical Sciences Collaborative Innovation Center of Biotherapy West China Hospital Sichuan University  Chengdu Sichuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meijun","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2010 Head &amp; 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