{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T23:10:35Z","timestamp":1792797035631,"version":"4.5.0"},"reference-count":274,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Liver fibrosis is a common pathological process, leading to the development of end\u2010stage liver diseases. It is triggered by various etiological drivers including viral hepatitis, metabolic\u2010associated steatotic liver disease (MASLD), and cholestasis. Given the substantial impact of liver fibrosis on individuals and its associated mortality rates, effective management of this condition is crucial for improving public health. Despite a growing number of preclinical studies and clinical trials, a systematic synthesis remains lacking. In this review, the molecular panorama of liver fibrogenesis is summarized at first, encompassing etiological drivers of chronic liver injury, key cellular players, core signaling pathways, and extracellular matrix dynamics. Therapeutic interventions in preclinical or clinical stages are systematically classified into two main categories: etiological treatment as the foundational approach and mechanism\u2010based antifibrotic therapies. Emerging and future therapeutic strategies, including those targeting gut\u2013liver axis, gut microbiota, and cell\u2010based therapies, are also addressed along with inherent challenges. Furthermore, future perspectives centered on precision medicine, combination therapies, novel target discovery, and advanced drug delivery systems are emphasized. This review offers a comprehensive overview of the etiologies, diagnostic approaches, pathogenic mechanisms, current development of antifibrotic agents, and prospects for future therapeutic directions of liver fibrosis.<\/jats:p>","DOI":"10.1002\/mco2.70750","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:50:39Z","timestamp":1777866639000},"source":"Crossref","is-referenced-by-count":3,"title":["Liver Fibrosis: Molecular Pathogenesis and Therapeutic Interventions"],"prefix":"10.1002","volume":"7","author":[{"given":"Jiaorong","family":"Qu","sequence":"first","affiliation":[{"name":"Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenqing","family":"Qin","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minghang","family":"Dong","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Ma","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Si","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8873-5252","authenticated-orcid":false,"given":"Runping","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ranyun","family":"Chen","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Changmeng","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojiaoyang","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,3]]},"reference":[{"key":"e_1_2_15_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2019.07.060"},{"key":"e_1_2_15_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2016.10.001"},{"key":"e_1_2_15_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105910"},{"key":"e_1_2_15_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mam.2018.09.002"},{"key":"e_1_2_15_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.03.017"},{"key":"e_1_2_15_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-020-00372-7"},{"key":"e_1_2_15_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.02.039"},{"key":"e_1_2_15_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrgastro.2017.38"},{"key":"e_1_2_15_10_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318813"},{"key":"e_1_2_15_11_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom12060824"},{"key":"e_1_2_15_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2025.02.033"},{"key":"e_1_2_15_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajpath.2025.06.009"},{"key":"e_1_2_15_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpha.2024.100979"},{"key":"e_1_2_15_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-5364(23)60505-9"},{"key":"e_1_2_15_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apm.2024.07.032"},{"key":"e_1_2_15_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-023-01091-7"},{"key":"e_1_2_15_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.07.022"},{"key":"e_1_2_15_19_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10051107"},{"key":"e_1_2_15_20_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.91572"},{"key":"e_1_2_15_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-023-01749-8"},{"key":"e_1_2_15_22_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.77256"},{"key":"e_1_2_15_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-025-02562-9"},{"key":"e_1_2_15_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2024.05.003"},{"key":"e_1_2_15_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25147873"},{"key":"e_1_2_15_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2015.04.011"},{"key":"e_1_2_15_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2016.11.001"},{"key":"e_1_2_15_28_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.ads9470"},{"key":"e_1_2_15_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2017.07.014"},{"key":"e_1_2_15_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.32181"},{"key":"e_1_2_15_31_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.07.006"},{"issue":"23","key":"e_1_2_15_32_1","first-page":"2296","article-title":"Use of Liver Imaging and Biopsy in Clinical Practice","volume":"377","author":"Gleeson J.","year":"2017","journal-title":"The New England Journal of Medicine"},{"key":"e_1_2_15_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.27173"},{"key":"e_1_2_15_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0168-8278(98)80134-7"},{"key":"e_1_2_15_35_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.1840200104"},{"key":"e_1_2_15_36_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2024.0392"},{"key":"e_1_2_15_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.08.021"},{"key":"e_1_2_15_38_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra2403308"},{"key":"e_1_2_15_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/hepr.13857"},{"key":"e_1_2_15_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31995"},{"key":"e_1_2_15_41_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000001167"},{"key":"e_1_2_15_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2021.154958"},{"key":"e_1_2_15_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.16596"},{"key":"e_1_2_15_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2017.12.001"},{"key":"e_1_2_15_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.02.004"},{"key":"e_1_2_15_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.10.023"},{"key":"e_1_2_15_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.04.025"},{"key":"e_1_2_15_48_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2024.06.009"},{"key":"e_1_2_15_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13634"},{"key":"e_1_2_15_50_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31843"},{"key":"e_1_2_15_51_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2016.01.038"},{"key":"e_1_2_15_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.11.045"},{"key":"e_1_2_15_53_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2036205"},{"key":"e_1_2_15_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2023.04.011"},{"key":"e_1_2_15_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01425-3"},{"key":"e_1_2_15_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(25)00067-6"},{"key":"e_1_2_15_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(25)01073-6"},{"key":"e_1_2_15_58_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2502242"},{"key":"e_1_2_15_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrendo.2018.10"},{"key":"e_1_2_15_60_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15427"},{"key":"e_1_2_15_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065843"},{"key":"e_1_2_15_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.07.039"},{"key":"e_1_2_15_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)32517-6"},{"key":"e_1_2_15_64_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2019.0007"},{"key":"e_1_2_15_65_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.07.025"},{"key":"e_1_2_15_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.04.042"},{"key":"e_1_2_15_67_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2018.07.027"},{"key":"e_1_2_15_68_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31622"},{"key":"e_1_2_15_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2018.11.032"},{"key":"e_1_2_15_70_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12916-022-02288-2"},{"key":"e_1_2_15_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01489-1"},{"key":"e_1_2_15_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-019-0310-0"},{"key":"e_1_2_15_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01495-3"},{"key":"e_1_2_15_74_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aav9701"},{"key":"e_1_2_15_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2020.118293"},{"key":"e_1_2_15_76_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc19-1892"},{"key":"e_1_2_15_77_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.18331"},{"key":"e_1_2_15_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00803-X"},{"key":"e_1_2_15_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.xcrm.2023.101193"},{"key":"e_1_2_15_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14888"},{"key":"e_1_2_15_81_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2028395"},{"key":"e_1_2_15_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(23)00068-7"},{"key":"e_1_2_15_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.04.003"},{"key":"e_1_2_15_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-020-0209-6"},{"key":"e_1_2_15_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(25)02114-2"},{"key":"e_1_2_15_86_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj-2024-083735"},{"key":"e_1_2_15_87_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13907"},{"key":"e_1_2_15_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.metabol.2023.155657"},{"key":"e_1_2_15_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.03.079"},{"key":"e_1_2_15_90_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.120070"},{"key":"e_1_2_15_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-019-0942-z"},{"key":"e_1_2_15_92_1","doi-asserted-by":"publisher","DOI":"10.1111\/apt.15331"},{"key":"e_1_2_15_93_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.13520"},{"key":"e_1_2_15_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00300-9"},{"key":"e_1_2_15_95_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2023.07.034"},{"key":"e_1_2_15_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30145"},{"key":"e_1_2_15_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2017.03.022"},{"key":"e_1_2_15_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.02.033"},{"key":"e_1_2_15_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)33041-7"},{"issue":"3","key":"e_1_2_15_100_1","first-page":"526","article-title":"Combined Obeticholic Acid and Apoptosis Inhibitor Treatment Alleviates Liver Fibrosis","volume":"9","author":"Zhou J.","year":"2019","journal-title":"APSB"},{"key":"e_1_2_15_101_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.14490"},{"key":"e_1_2_15_102_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.10.018"},{"key":"e_1_2_15_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30509"},{"key":"e_1_2_15_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31205"},{"key":"e_1_2_15_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(25)00208-0"},{"key":"e_1_2_15_106_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b00907"},{"key":"e_1_2_15_107_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000439"},{"key":"e_1_2_15_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.10.023"},{"key":"e_1_2_15_109_1","doi-asserted-by":"publisher","DOI":"10.1111\/jvh.13608"},{"key":"e_1_2_15_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2021.01.047"},{"key":"e_1_2_15_111_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543784.2020.1763302"},{"key":"e_1_2_15_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.10.001"},{"key":"e_1_2_15_113_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010818-021059"},{"key":"e_1_2_15_114_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2014.12.034"},{"key":"e_1_2_15_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2019.117175"},{"key":"e_1_2_15_116_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30590"},{"key":"e_1_2_15_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(22)00017-6"},{"key":"e_1_2_15_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2024.e38339"},{"key":"e_1_2_15_119_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa266"},{"key":"e_1_2_15_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.07.018"},{"key":"e_1_2_15_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(20)30692-7"},{"key":"e_1_2_15_122_1","doi-asserted-by":"publisher","DOI":"10.7448\/IAS.20.1.21426"},{"key":"e_1_2_15_123_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2013-305606"},{"key":"e_1_2_15_124_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12416"},{"key":"e_1_2_15_125_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.13193"},{"key":"e_1_2_15_126_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2015.04.009"},{"key":"e_1_2_15_127_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15596"},{"key":"e_1_2_15_128_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-019-2027-8"},{"key":"e_1_2_15_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.05.048"},{"key":"e_1_2_15_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102582"},{"key":"e_1_2_15_131_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-015-9633-1"},{"key":"e_1_2_15_132_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abg9241"},{"key":"e_1_2_15_133_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12072-020-10069-3"},{"key":"e_1_2_15_134_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.12.026"},{"key":"e_1_2_15_135_1","doi-asserted-by":"publisher","DOI":"10.1002\/biof.1724"},{"key":"e_1_2_15_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.117794"},{"key":"e_1_2_15_137_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.8010"},{"key":"e_1_2_15_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2014.05.012"},{"issue":"11","key":"e_1_2_15_139_1","first-page":"1411","article-title":"Polydatin Attenuates Diet\u2010induced Nonalcoholic Steatohepatitis and Fibrosis in Mice","volume":"14","author":"Li R.","year":"2018","journal-title":"International Journal of Molecular Sciences"},{"key":"e_1_2_15_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2017.10.065"},{"key":"e_1_2_15_141_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29514"},{"key":"e_1_2_15_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.02.027"},{"key":"e_1_2_15_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2018.06.012"},{"key":"e_1_2_15_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2019.11.024"},{"issue":"1","key":"e_1_2_15_145_1","first-page":"140","article-title":"Deferasirox Improves Liver Fibrosis in Beta\u2010thalassaemia Major Patients. A Five\u2010year Longitudinal Study From a Single Thalassaemia Centre","volume":"181","author":"Sousos N.","year":"2018","journal-title":"British Journal of Pharmacology"},{"key":"e_1_2_15_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115965"},{"key":"e_1_2_15_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117334"},{"key":"e_1_2_15_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2019.108863"},{"key":"e_1_2_15_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2018.11.027"},{"key":"e_1_2_15_150_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.29477"},{"key":"e_1_2_15_151_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.31108"},{"key":"e_1_2_15_152_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.83530"},{"key":"e_1_2_15_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2023.04.003"},{"key":"e_1_2_15_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(23)00010-9"},{"key":"e_1_2_15_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2022.109020"},{"key":"e_1_2_15_156_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116662"},{"key":"e_1_2_15_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2017.12.023"},{"key":"e_1_2_15_158_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.04.040"},{"issue":"3","key":"e_1_2_15_159_1","first-page":"1","article-title":"Protective Effect of Oligonol on Dimethylnitrosamine\u2010Induced Liver Fibrosis in Rats via the JNK\/NF\u2010kappaB and PI3K\/Akt\/Nrf2 Signaling Pathways","volume":"10","author":"Lee C.","year":"2021","journal-title":"Antioxidants (Basel)"},{"key":"e_1_2_15_160_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.801982"},{"key":"e_1_2_15_161_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10787-023-01382-y"},{"key":"e_1_2_15_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2021.114433"},{"key":"e_1_2_15_163_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21082790"},{"key":"e_1_2_15_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.153960"},{"key":"e_1_2_15_165_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.01277"},{"key":"e_1_2_15_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2023.155125"},{"key":"e_1_2_15_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2019.152948"},{"key":"e_1_2_15_168_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2018.00187"},{"key":"e_1_2_15_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117283"},{"key":"e_1_2_15_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117516"},{"key":"e_1_2_15_171_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41401-023-01220-5"},{"key":"e_1_2_15_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2024.105491"},{"key":"e_1_2_15_173_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.96184"},{"key":"e_1_2_15_174_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1160445"},{"key":"e_1_2_15_175_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.117730"},{"key":"e_1_2_15_176_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.117486"},{"key":"e_1_2_15_177_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115794"},{"key":"e_1_2_15_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113834"},{"key":"e_1_2_15_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2024.118057"},{"key":"e_1_2_15_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2017.12.001"},{"key":"e_1_2_15_181_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1875-5364(23)60416-9"},{"key":"e_1_2_15_182_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.104069"},{"key":"e_1_2_15_183_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.15715"},{"key":"e_1_2_15_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2022.05.056"},{"key":"e_1_2_15_185_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-023-49240-9"},{"key":"e_1_2_15_186_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.5c13607"},{"key":"e_1_2_15_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cbi.2020.109098"},{"key":"e_1_2_15_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154587"},{"key":"e_1_2_15_189_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.04.042"},{"key":"e_1_2_15_190_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.745561"},{"key":"e_1_2_15_191_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2023.1098463"},{"key":"e_1_2_15_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chmed.2023.07.003"},{"key":"e_1_2_15_193_1","doi-asserted-by":"publisher","DOI":"10.1111\/liv.12638"},{"key":"e_1_2_15_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2016.03.011"},{"key":"e_1_2_15_195_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2023.123639"},{"key":"e_1_2_15_196_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.14543"},{"key":"e_1_2_15_197_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15490"},{"key":"e_1_2_15_198_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.03.029"},{"key":"e_1_2_15_199_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.22237"},{"key":"e_1_2_15_200_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110586"},{"key":"e_1_2_15_201_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.15933"},{"key":"e_1_2_15_202_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.10.013"},{"key":"e_1_2_15_203_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101600"},{"key":"e_1_2_15_204_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.6620"},{"key":"e_1_2_15_205_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-21862-1"},{"key":"e_1_2_15_206_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115210"},{"key":"e_1_2_15_207_1","doi-asserted-by":"publisher","DOI":"10.1038\/aps.2016.35"},{"key":"e_1_2_15_208_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113227"},{"key":"e_1_2_15_209_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2022.911250"},{"key":"e_1_2_15_210_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2020.113021"},{"key":"e_1_2_15_211_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.410"},{"key":"e_1_2_15_212_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.116059"},{"key":"e_1_2_15_213_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2021.01.071"},{"key":"e_1_2_15_214_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.684857"},{"key":"e_1_2_15_215_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2017.09.014"},{"key":"e_1_2_15_216_1","doi-asserted-by":"publisher","DOI":"10.1142\/S0192415X17500227"},{"key":"e_1_2_15_217_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10495-019-01568-2"},{"key":"e_1_2_15_218_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.13158"},{"key":"e_1_2_15_219_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.7558"},{"key":"e_1_2_15_220_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.11.030"},{"issue":"45","key":"e_1_2_15_221_1","first-page":"17295","article-title":"Schisandrin B Promotes Hepatic Stellate Cell Ferroptosis via Wnt Pathway\u2010Mediated Ly6Clo Macrophages","volume":"71","author":"Li X.","year":"2023","journal-title":"Journal of Agricultural and Food Chemistry"},{"key":"e_1_2_15_222_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154117"},{"key":"e_1_2_15_223_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.114173"},{"key":"e_1_2_15_224_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.06.133"},{"key":"e_1_2_15_225_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2022.102435"},{"key":"e_1_2_15_226_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.108869"},{"key":"e_1_2_15_227_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15997"},{"key":"e_1_2_15_228_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000326"},{"key":"e_1_2_15_229_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.114653"},{"key":"e_1_2_15_230_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106590"},{"key":"e_1_2_15_231_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jff.2023.105773"},{"key":"e_1_2_15_232_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242216502"},{"key":"e_1_2_15_233_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.30975"},{"key":"e_1_2_15_234_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-313432"},{"key":"e_1_2_15_235_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-023-00904-3"},{"key":"e_1_2_15_236_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2020.11.013"},{"key":"e_1_2_15_237_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-37459-z"},{"key":"e_1_2_15_238_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-022-03543-z"},{"key":"e_1_2_15_239_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13093192"},{"key":"e_1_2_15_240_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm13030441"},{"key":"e_1_2_15_241_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dld.2015.08.018"},{"key":"e_1_2_15_242_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(17)30326-6"},{"key":"e_1_2_15_243_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-053190"},{"key":"e_1_2_15_244_1","doi-asserted-by":"publisher","DOI":"10.7326\/M15-1774"},{"key":"e_1_2_15_245_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cgh.2021.12.044"},{"key":"e_1_2_15_246_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2017.05.016"},{"key":"e_1_2_15_247_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.762654"},{"key":"e_1_2_15_248_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2023.106679"},{"key":"e_1_2_15_249_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2025.1574385"},{"key":"e_1_2_15_250_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2025.03.006"},{"key":"e_1_2_15_251_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26062658"},{"key":"e_1_2_15_252_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2024.0438"},{"key":"e_1_2_15_253_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2024.0343"},{"key":"e_1_2_15_254_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2024.0357"},{"key":"e_1_2_15_255_1","doi-asserted-by":"publisher","DOI":"10.3350\/cmh.2024.0022"},{"key":"e_1_2_15_256_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12131712"},{"key":"e_1_2_15_257_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2014.03.019"},{"key":"e_1_2_15_258_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2023.116191"},{"key":"e_1_2_15_259_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13020-024-01038-1"},{"key":"e_1_2_15_260_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10123604"},{"key":"e_1_2_15_261_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2025.114864"},{"key":"e_1_2_15_262_1","doi-asserted-by":"publisher","DOI":"10.1038\/cdd.2013.21"},{"key":"e_1_2_15_263_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2021.111342"},{"key":"e_1_2_15_264_1","doi-asserted-by":"publisher","DOI":"10.1002\/mco2.354"},{"key":"e_1_2_15_265_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(22)00446-6"},{"key":"e_1_2_15_266_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm12111812"},{"key":"e_1_2_15_267_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.2c19269"},{"key":"e_1_2_15_268_1","doi-asserted-by":"publisher","DOI":"10.1002\/adhm.202303710"},{"key":"e_1_2_15_269_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.carbpol.2021.117964"},{"key":"e_1_2_15_270_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2023.12.027"},{"key":"e_1_2_15_271_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2019.119616"},{"key":"e_1_2_15_272_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2022.08.065"},{"key":"e_1_2_15_273_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.8b06924"},{"key":"e_1_2_15_274_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.3c06107"},{"key":"e_1_2_15_275_1","doi-asserted-by":"publisher","DOI":"10.1021\/nn505166x"}],"container-title":["MedComm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.70750","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mco2.70750","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.70750","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T06:41:37Z","timestamp":1783838497000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mco2.70750"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":274,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1002\/mco2.70750"],"URL":"https:\/\/doi.org\/10.1002\/mco2.70750","archive":["Portico"],"relation":{},"ISSN":["2688-2663","2688-2663"],"issn-type":[{"value":"2688-2663","type":"print"},{"value":"2688-2663","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5]]},"article-number":"e70750"}}