{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T18:53:12Z","timestamp":1789757592817,"version":"4.0.1"},"reference-count":67,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T00:00:00Z","timestamp":1777766400000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82574625"],"award-info":[{"award-number":["82574625"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82574858"],"award-info":[{"award-number":["82574858"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82030124"],"award-info":[{"award-number":["82030124"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Heart failure (HF) following myocardial infarction remains a leading cause of global morbidity and mortality, necessitating novel therapeutic strategies. Salvianolic acid B (SalB), one of the major active components of\n                    <jats:italic>Salvia miltiorrhiza<\/jats:italic>\n                    Bunge, has been shown to effectively reverse ischemia\u2010induced myocardial infarction and improve cardiac function. Here, we report a novel mechanism by which SalB treats postmyocardial infarction heart failure by promoting cardiomyocyte re\u2010entry into the cell cycle. A novel protein target of SalB, Prohibitin 1 (PHB1), was identified using chemical biology techniques. Experiments involving overexpression and knockdown of PHB1 have demonstrated that SalB promotes cardiomyocyte mitosis by acting on PHB1, which in turn upregulates the phosphorylation level of the Raf\u2010ERK pathway. Molecular dynamics simulations provide a comprehensive explanation for the mechanism by which SalB enhances Raf phosphorylation. The findings reveal that SalB binds to the C\u2010terminal of PHB1\/2 heterodimer, inducing a conformational change that enhances Raf\u2010ERK pathway activation via Akt\u2010mediated phosphorylation, thereby promoting cardiomyocyte mitosis. The findings of this study propose a promising new molecular mechanism through which SalB can contribute to the preservation and restoration of cardiac function.\n                  <\/jats:p>","DOI":"10.1002\/mco2.70752","type":"journal-article","created":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:53:24Z","timestamp":1777866804000},"source":"Crossref","is-referenced-by-count":2,"title":["A Novel Mechanism of Salvianolic Acid B in Postmyocardial Infarction Cardiac Protection: PHB1\u2010Driven Raf\u2010ERK Pathway Activation Promotes Cardiomyocyte Mitosis"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9901-663X","authenticated-orcid":false,"given":"Ce","family":"Cao","sequence":"first","affiliation":[{"name":"National Clinical Research Center for Chinese Medicine Cardiology Beijing Key Laboratory of Chinese Materia Pharmacology Xiyuan Hospital of China Academy of Chinese Medical Sciences  Beijing 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