{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T20:23:01Z","timestamp":1790886181519,"version":"4.1.0"},"reference-count":270,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T00:00:00Z","timestamp":1779062400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004826","name":"Natural Science Foundation of Beijing Municipality","doi-asserted-by":"publisher","award":["7242254"],"award-info":[{"award-number":["7242254"]}],"id":[{"id":"10.13039\/501100004826","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Neutrophils are the most abundant innate immune cells and are pivotal first responders in host defense, playing an important role in maintaining body homeostasis and regulating pathological conditions. Growing evidence indicates that neutrophils exhibit functional heterogeneity and participate in immune regulation through processes such as neutrophil extracellular trap formation (NETosis). These findings have expanded the traditional view of neutrophils as short\u2010lived effector cells. Nevertheless, how distinct neutrophil states are temporally coordinated during disease development, and how this coordination may be therapeutically exploited, remains insufficiently understood. In this review, we provide a comprehensive overview of neutrophil biology, focusing on functional heterogeneity, NETosis, and their roles in infectious diseases, autoimmune disorders, and cancers. We further discuss emerging therapeutic strategies targeting neutrophils, as well as advanced technologies that have enabled high\u2010resolution characterization of neutrophil states and functions. Building on the evidence above, the concept of \u201cneutrophil immune clock\u201d is proposed to describe the temporal changes in neutrophil\u2010mediated immune responses. A time\u2010resolved perspective on neutrophil responses may offer new insights into disease progression and support the development of neutrophil\u2010targeted strategies for disease prevention and therapy.<\/jats:p>","DOI":"10.1002\/mco2.70770","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T06:51:38Z","timestamp":1779173498000},"source":"Crossref","is-referenced-by-count":3,"title":["The Role of Neutrophils and NETosis in Diseases: The Implications for Therapy"],"prefix":"10.1002","volume":"7","author":[{"given":"Zhen","family":"Ma","sequence":"first","affiliation":[{"name":"Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases Experimental Research Center China Academy of Chinese Medical Sciences  Beijing China"},{"name":"State Key Laboratory For Quality Ensurance and Sustainable Use of Dao\u2010di Herbs China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qing","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Life Sciences Beijing University of Chinese Medicine  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusheng","family":"Zhang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases Experimental Research Center China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Li","sequence":"additional","affiliation":[{"name":"School of Life Sciences Shanxi University  Taiyuan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongwei","family":"Wu","sequence":"additional","affiliation":[{"name":"State Key Laboratory For Quality Ensurance and Sustainable Use of Dao\u2010di Herbs China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongjun","family":"Yang","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases Experimental Research Center China Academy of Chinese Medical Sciences  Beijing China"},{"name":"State Key Laboratory For Quality Ensurance and Sustainable Use of Dao\u2010di Herbs China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9625-8476","authenticated-orcid":false,"given":"Xianyu","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Key Laboratory of Traditional Chinese Medicine Basic Research on Prevention and Treatment for Major Diseases Experimental Research Center China Academy of Chinese Medical Sciences  Beijing China"},{"name":"State Key Laboratory For Quality Ensurance and Sustainable Use of Dao\u2010di Herbs China Academy of Chinese Medical Sciences  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,18]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-025-09807-0"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2010.11.011"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3399"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2019.04.012"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-023-01843-6"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2019.04.013"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2156"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1092385"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2017.105"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200606027"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2016.04.016"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.3109\/00365513.2011.602422"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2013.04.040"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2012.05.021"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju124"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1697854"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2025.12.020"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-019-0141-8"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12448"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0736-z"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0496-9"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.12949"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-688887"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI41649"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2020.165920"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/7966089"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-64780-4"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.07.017"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1128\/MMBR.00057-17"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201902542R"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M701120200"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1423-0410.1978.tb02938.x"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2016-313535"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2022.06.015"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2017-03-768507"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-43573-9"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.117324"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3599"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15367"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00576"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.abb.2018.01.004"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.701227"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms242115805"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.1959"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-022-02860-4"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1139\/bcb-2017-0290"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.15252\/emmm.201506083"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri3386"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2019.03.010"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2018.10.007"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-019-0571-2"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.11.001"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20250240"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.adn3080"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60664-1"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.iy.09.040191.001415"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.13406"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.12980"},{"key":"e_1_2_14_60_1","doi-asserted-by":"publisher","DOI":"10.1038\/79775"},{"key":"e_1_2_14_61_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI138136"},{"key":"e_1_2_14_62_1","doi-asserted-by":"publisher","DOI":"10.1097\/HEP.0000000000000868"},{"key":"e_1_2_14_63_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1444558"},{"key":"e_1_2_14_64_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.1MR1014-502R"},{"key":"e_1_2_14_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2018.15"},{"key":"e_1_2_14_66_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-019-0471-y"},{"key":"e_1_2_14_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2024.08.008"},{"key":"e_1_2_14_68_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.708770"},{"key":"e_1_2_14_69_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2025.103603"},{"key":"e_1_2_14_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-025-04049-5"},{"key":"e_1_2_14_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc.2016.52"},{"key":"e_1_2_14_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.06.017"},{"key":"e_1_2_14_73_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells13030208"},{"key":"e_1_2_14_74_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-025-04172-1"},{"key":"e_1_2_14_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2021.12.009"},{"key":"e_1_2_14_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.12.039"},{"key":"e_1_2_14_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.06.005"},{"key":"e_1_2_14_78_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2024.03.018"},{"key":"e_1_2_14_79_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keae300"},{"key":"e_1_2_14_80_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1334205"},{"key":"e_1_2_14_81_1","doi-asserted-by":"publisher","DOI":"10.1093\/jleuko\/qiae025"},{"key":"e_1_2_14_82_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.adf9706"},{"key":"e_1_2_14_83_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.119.040232"},{"key":"e_1_2_14_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2005.10.041"},{"key":"e_1_2_14_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature06685"},{"key":"e_1_2_14_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2010.05390.x"},{"key":"e_1_2_14_87_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00102"},{"key":"e_1_2_14_88_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100588"},{"key":"e_1_2_14_89_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.1059686"},{"key":"e_1_2_14_90_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M115.640094"},{"key":"e_1_2_14_91_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2011.179"},{"key":"e_1_2_14_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.10.003"},{"key":"e_1_2_14_93_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20181468"},{"key":"e_1_2_14_94_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2194"},{"key":"e_1_2_14_95_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.93812"},{"key":"e_1_2_14_96_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40164-025-00670-3"},{"key":"e_1_2_14_97_1","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.64.13.19"},{"key":"e_1_2_14_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2022.110710"},{"key":"e_1_2_14_99_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-025-01107-7"},{"key":"e_1_2_14_100_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24065125"},{"key":"e_1_2_14_101_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aar6689"},{"key":"e_1_2_14_102_1","doi-asserted-by":"publisher","DOI":"10.1155\/jimr\/3037744"},{"key":"e_1_2_14_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-023-01058-1"},{"key":"e_1_2_14_104_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25137216"},{"key":"e_1_2_14_105_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1170603"},{"key":"e_1_2_14_106_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines13030597"},{"key":"e_1_2_14_107_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.785222"},{"key":"e_1_2_14_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2020.10.015"},{"key":"e_1_2_14_109_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12437"},{"key":"e_1_2_14_110_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-05387-y"},{"key":"e_1_2_14_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2019.165542"},{"key":"e_1_2_14_112_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI169893"},{"key":"e_1_2_14_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2022.166581"},{"key":"e_1_2_14_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-025-01278-7"},{"key":"e_1_2_14_115_1","doi-asserted-by":"publisher","DOI":"10.1093\/jleuko\/qiae243"},{"key":"e_1_2_14_116_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-025-02301-9"},{"key":"e_1_2_14_117_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1251086"},{"key":"e_1_2_14_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2020.10.011"},{"key":"e_1_2_14_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2021.109143"},{"key":"e_1_2_14_120_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.906311"},{"key":"e_1_2_14_121_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom9010032"},{"key":"e_1_2_14_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.103256"},{"key":"e_1_2_14_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/nchembio.1735"},{"key":"e_1_2_14_124_1","doi-asserted-by":"publisher","DOI":"10.1002\/JLB.3A1220-789RR"},{"key":"e_1_2_14_125_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15794"},{"key":"e_1_2_14_126_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43556-025-00254-x"},{"key":"e_1_2_14_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41420-021-00491-3"},{"key":"e_1_2_14_128_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1033815"},{"key":"e_1_2_14_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2014.06.044"},{"key":"e_1_2_14_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2015.10.398"},{"key":"e_1_2_14_131_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1652608"},{"key":"e_1_2_14_132_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciimmunol.aar6676"},{"key":"e_1_2_14_133_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aax7942"},{"key":"e_1_2_14_134_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1300436"},{"key":"e_1_2_14_135_1","doi-asserted-by":"publisher","DOI":"10.1093\/jleuko\/qiad038"},{"key":"e_1_2_14_136_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.01.002"},{"key":"e_1_2_14_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2024.116379"},{"key":"e_1_2_14_138_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.901590"},{"key":"e_1_2_14_139_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00962"},{"key":"e_1_2_14_140_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mucimm.2024.05.007"},{"key":"e_1_2_14_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrneph.2017.165"},{"key":"e_1_2_14_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-023-01115-9"},{"key":"e_1_2_14_143_1","doi-asserted-by":"publisher","DOI":"10.1631\/jzus.B2101075"},{"key":"e_1_2_14_144_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCM.0b013e3182120cb8"},{"key":"e_1_2_14_145_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-03082-3"},{"key":"e_1_2_14_146_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-021-03481-0"},{"key":"e_1_2_14_147_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1538282"},{"key":"e_1_2_14_148_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168882"},{"key":"e_1_2_14_149_1","doi-asserted-by":"publisher","DOI":"10.1097\/JS9.0000000000000789"},{"key":"e_1_2_14_150_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.135678"},{"key":"e_1_2_14_151_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00655-20"},{"key":"e_1_2_14_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaip.2023.04.018"},{"key":"e_1_2_14_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2021.04.014"},{"key":"e_1_2_14_154_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01933-x"},{"key":"e_1_2_14_155_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41577-022-00787-0"},{"key":"e_1_2_14_156_1","doi-asserted-by":"publisher","DOI":"10.1136\/rmdopen-2023-003847"},{"key":"e_1_2_14_157_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01601"},{"key":"e_1_2_14_158_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100450"},{"key":"e_1_2_14_159_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1202388"},{"key":"e_1_2_14_160_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0902199"},{"key":"e_1_2_14_161_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-013-0375-7"},{"key":"e_1_2_14_162_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.41395"},{"key":"e_1_2_14_163_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2025.103399"},{"key":"e_1_2_14_164_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3001180"},{"key":"e_1_2_14_165_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909927107"},{"key":"e_1_2_14_166_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.4027"},{"key":"e_1_2_14_167_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reuma.2023.08.001"},{"key":"e_1_2_14_168_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3005580"},{"key":"e_1_2_14_169_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-0381-3"},{"key":"e_1_2_14_170_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.03033"},{"key":"e_1_2_14_171_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1309835"},{"key":"e_1_2_14_172_1","doi-asserted-by":"publisher","DOI":"10.1111\/eci.13037"},{"key":"e_1_2_14_173_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2025.1436311"},{"key":"e_1_2_14_174_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-3962"},{"key":"e_1_2_14_175_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-024-02004-z"},{"key":"e_1_2_14_176_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-023-01196-z"},{"key":"e_1_2_14_177_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-23-1542"},{"key":"e_1_2_14_178_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2312855121"},{"key":"e_1_2_14_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.09.012"},{"key":"e_1_2_14_180_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.5753"},{"key":"e_1_2_14_181_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-022-05495-0"},{"key":"e_1_2_14_182_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-020-0281-y"},{"key":"e_1_2_14_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2020.101409"},{"key":"e_1_2_14_184_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-018-0229-5"},{"key":"e_1_2_14_185_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2394-6"},{"key":"e_1_2_14_186_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-020-00285-6"},{"key":"e_1_2_14_187_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsami.5c00670"},{"key":"e_1_2_14_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.05.082"},{"key":"e_1_2_14_189_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1039969"},{"key":"e_1_2_14_190_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-024-03178-6"},{"key":"e_1_2_14_191_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.182766"},{"key":"e_1_2_14_192_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20190354"},{"key":"e_1_2_14_193_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-20-4125"},{"key":"e_1_2_14_194_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2020.12.012"},{"key":"e_1_2_14_195_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aag1711"},{"key":"e_1_2_14_196_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-025-03370-2"},{"key":"e_1_2_14_197_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2024-009082"},{"key":"e_1_2_14_198_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-020-0783-5"},{"key":"e_1_2_14_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2023.09.004"},{"key":"e_1_2_14_200_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-28438-x"},{"key":"e_1_2_14_201_1","doi-asserted-by":"publisher","DOI":"10.1002\/adma.201706245"},{"key":"e_1_2_14_202_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201801674"},{"key":"e_1_2_14_203_1","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2022-0211"},{"key":"e_1_2_14_204_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119952"},{"key":"e_1_2_14_205_1","doi-asserted-by":"publisher","DOI":"10.1038\/nnano.2017.54"},{"key":"e_1_2_14_206_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202004381"},{"key":"e_1_2_14_207_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41565-023-01374-7"},{"key":"e_1_2_14_208_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12951-023-01773-x"},{"key":"e_1_2_14_209_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2023.01.002"},{"key":"e_1_2_14_210_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-06511-9"},{"key":"e_1_2_14_211_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41573-025-00108-9"},{"key":"e_1_2_14_212_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V93.10.3505.410k20_3505_3511"},{"key":"e_1_2_14_213_1","doi-asserted-by":"publisher","DOI":"10.1093\/ndt\/gfm852"},{"key":"e_1_2_14_214_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvv159"},{"key":"e_1_2_14_215_1","doi-asserted-by":"publisher","DOI":"10.1080\/19420862.2023.2281763"},{"key":"e_1_2_14_216_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16596-9"},{"key":"e_1_2_14_217_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01749"},{"key":"e_1_2_14_218_1","doi-asserted-by":"publisher","DOI":"10.1002\/ptr.8311"},{"key":"e_1_2_14_219_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsnano.4c18555"},{"key":"e_1_2_14_220_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-60327-216-2_6"},{"key":"e_1_2_14_221_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2024.03.037"},{"key":"e_1_2_14_222_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-024-01783-w"},{"key":"e_1_2_14_223_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2013-07-513242"},{"key":"e_1_2_14_224_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2020.08.004"},{"key":"e_1_2_14_225_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10875-016-0358-2"},{"key":"e_1_2_14_226_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1940"},{"key":"e_1_2_14_227_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1170"},{"key":"e_1_2_14_228_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2227-7"},{"key":"e_1_2_14_229_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrg2484"},{"key":"e_1_2_14_230_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1366125"},{"key":"e_1_2_14_231_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41368-025-00366-8"},{"key":"e_1_2_14_232_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01514"},{"key":"e_1_2_14_233_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00423"},{"key":"e_1_2_14_234_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11357-024-01286-x"},{"key":"e_1_2_14_235_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.42023"},{"key":"e_1_2_14_236_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.172569"},{"key":"e_1_2_14_237_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2024-332730"},{"key":"e_1_2_14_238_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.07.097"},{"key":"e_1_2_14_239_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1876-x"},{"key":"e_1_2_14_240_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03475-6"},{"key":"e_1_2_14_241_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.12.018"},{"key":"e_1_2_14_242_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2016.1232221"},{"key":"e_1_2_14_243_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-024-01562-5"},{"key":"e_1_2_14_244_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-023-02510-5"},{"key":"e_1_2_14_245_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00262-013-1476-9"},{"key":"e_1_2_14_246_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14407"},{"key":"e_1_2_14_247_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.08.001"},{"key":"e_1_2_14_248_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2025.03.009"},{"key":"e_1_2_14_249_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2024.02.005"},{"key":"e_1_2_14_250_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-020-0412-0"},{"key":"e_1_2_14_251_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-023-01505-1"},{"key":"e_1_2_14_252_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coi.2014.03.009"},{"key":"e_1_2_14_253_1","doi-asserted-by":"publisher","DOI":"10.1002\/cyto.a.22503"},{"key":"e_1_2_14_254_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2023.1129633"},{"key":"e_1_2_14_255_1","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/348757"},{"key":"e_1_2_14_256_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00281-011-0295-3"},{"key":"e_1_2_14_257_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiad442"},{"key":"e_1_2_14_258_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2018.03.020"},{"key":"e_1_2_14_259_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri.2016.49"},{"key":"e_1_2_14_260_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19020468"},{"key":"e_1_2_14_261_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2014.04.011"},{"key":"e_1_2_14_262_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2018.02171"},{"key":"e_1_2_14_263_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2017.07.024"},{"key":"e_1_2_14_264_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-024-72027-5"},{"key":"e_1_2_14_265_1","doi-asserted-by":"publisher","DOI":"10.1080\/01443615.2024.2361858"},{"key":"e_1_2_14_266_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2019.01.006"},{"key":"e_1_2_14_267_1","first-page":"360","article-title":"Neutrophil to Lymphocyte Ratio and Cancer Prognosis: an Umbrella Review of Systematic Reviews and Meta\u2010Analyses of Observational Studies","volume":"18","author":"Cupp M. A.","year":"2020","journal-title":"BMC Medicine [Electronic Resource]"},{"key":"e_1_2_14_268_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-024-01768-2"},{"key":"e_1_2_14_269_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2024.177144"},{"key":"e_1_2_14_270_1","doi-asserted-by":"publisher","DOI":"10.12659\/MSM.950963"},{"key":"e_1_2_14_271_1","doi-asserted-by":"publisher","DOI":"10.1200\/OP-25-00661"}],"container-title":["MedComm"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.70770","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/mco2.70770","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/mco2.70770","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T05:41:38Z","timestamp":1783489298000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/mco2.70770"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,18]]},"references-count":270,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1002\/mco2.70770"],"URL":"https:\/\/doi.org\/10.1002\/mco2.70770","archive":["Portico"],"relation":{},"ISSN":["2688-2663","2688-2663"],"issn-type":[{"value":"2688-2663","type":"print"},{"value":"2688-2663","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,18]]},"article-number":"e70770"}}