{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T06:16:45Z","timestamp":1783491405885,"version":"3.55.0"},"reference-count":48,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T00:00:00Z","timestamp":1780531200000},"content-version":"vor","delay-in-days":3,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T00:00:00Z","timestamp":1780272000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["21876176"],"award-info":[{"award-number":["21876176"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["MedComm"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>\n                    Lung cancer (LC) is a leading cause of cancer mortality worldwide, frequently complicated by malignant pleural effusion (MPE). This study aimed to investigate volatile organic compounds (VOCs) in pleural effusion to identify metabolic biomarkers for LC. A total of 107 LC\u2010related MPE and 112 benign pleural effusion (BPE) patients were enrolled and divided into discovery (MPE:\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a075; BPE:\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a078) and validation (MPE:\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a032; BPE:\n                    <jats:italic>n<\/jats:italic>\n                    \u00a0=\u00a034) cohorts. Paired tumor and adjacent nontumor tissues from 14 LC patients formed an independent cohort. Differential VOCs were identified using criteria of\n                    <jats:italic>q<\/jats:italic>\n                    \u00a0&lt;\u00a00.05, |log\n                    <jats:sub>2<\/jats:sub>\n                    fold change|\u00a0&gt;\u00a01, and VIP\u00a0&gt;\u00a01.5 in both the pleural effusion discovery cohort and the tissue cohort. Hexanal was identified as the only LC\u2010associated VOC present across both compartments. In the validation cohort, hexanal demonstrated strong diagnostic performance in distinguishing MPE from BPE (AUC\u00a0=\u00a00.8339; sensitivity 75.00%; specificity 65.71%). Single\u2010cell analysis indicated that hexanal accumulation is linked to fatty acid metabolism reprogramming. This study supports pleural effusion\u2010based gas biopsy as a promising LC diagnostic approach.\n                  <\/jats:p>","DOI":"10.1002\/mco2.70787","type":"journal-article","created":{"date-parts":[[2026,6,5]],"date-time":"2026-06-05T06:43:00Z","timestamp":1780641780000},"source":"Crossref","is-referenced-by-count":0,"title":["Gas Biopsy of Pleural Effusion to Diagnose Lung Cancer by Mass Spectrometry"],"prefix":"10.1002","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-7592-4813","authenticated-orcid":false,"given":"Wenting","family":"Liu","sequence":"first","affiliation":[{"name":"Hefei Cancer Hospital of CAS Institute of Health and Medical Technology, Hefei Institutes of Physical Science Chinese Academy of Sciences (CAS)  Hefei Anhui China"},{"name":"Science Island Branch Graduate School of the University of Science and Technology of China  Hefei Anhui China"},{"name":"Department of Geriatric Medicine The First Affiliated Hospital of the University of Science and Technology of China Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui China"},{"name":"Anhui Province Key Laboratory of Medical Physics and Technology  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2276-2519","authenticated-orcid":false,"given":"Jian","family":"Qi","sequence":"additional","affiliation":[{"name":"Hefei Cancer Hospital of CAS Institute of Health and Medical Technology, Hefei Institutes of Physical Science Chinese Academy of Sciences (CAS)  Hefei Anhui China"},{"name":"Science Island Branch Graduate School of the University of Science and Technology of China  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajing","family":"Chu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Biodiversity Conservation and Characteristic Resource Utilization in Southwest Anhui School of Life Sciences Anqing Forestry 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Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Ke","sequence":"additional","affiliation":[{"name":"Hefei Cancer Hospital of CAS Institute of Health and Medical Technology, Hefei Institutes of Physical Science Chinese Academy of Sciences (CAS)  Hefei Anhui China"},{"name":"Science Island Branch Graduate School of the University of Science and Technology of China  Hefei Anhui China"},{"name":"Anhui Province Key Laboratory of Medical Physics and Technology  Hefei Anhui China"},{"name":"Department of Thoracic Surgery The First Affiliated Hospital of the University of Science and Technology of China Division of Life Sciences and Medicine University of Science and Technology of China  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiangxue","family":"Zheng","sequence":"additional","affiliation":[{"name":"Hefei Cancer Hospital of CAS Institute of Health and Medical Technology, Hefei Institutes of Physical Science Chinese Academy of Sciences (CAS)  Hefei Anhui China"},{"name":"Science Island Branch Graduate School of the University of Science and Technology of China  Hefei Anhui China"},{"name":"Anhui Province Key Laboratory of Medical Physics and Technology  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Lu","sequence":"additional","affiliation":[{"name":"Hefei Cancer Hospital of CAS Institute of Health and Medical Technology, Hefei Institutes of Physical Science Chinese Academy of Sciences (CAS)  Hefei Anhui China"},{"name":"Science Island Branch Graduate School of the University of Science and Technology of China  Hefei Anhui China"},{"name":"Anhui Province Key Laboratory of Medical Physics and Technology  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dianlong","family":"Ge","sequence":"additional","affiliation":[{"name":"Hefei Cancer Hospital of CAS Institute of Health and Medical Technology, Hefei 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